Results 121 to 130 of about 736,541 (316)
Dexmedetomidine Associated with Intraoperative Floppy Iris Syndrome in Ophthalmic Surgery [PDF]
Journal of Clinical and Diagnostic Research, 2020 Inci Dersu
doaj +1 more source
Use of a clinical PET/CT scanner for whole body biodistribution of intranasal nanoparticles [PDF]
arXiv, 2017 Whole body biodistribution of 100 nanometer sized polymer micellar nanoparticles (NPs) was determined following intranasal administration using PET/CT imaging on a clinical scanner. Nanoparticles labeled with Zirconium 89 were administered intranasally or intravenously to Sprague Dawley rats followed by serial ex vivo PET/CT imaging in a clinical ...
arxiv
A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis
Advanced Science, EarlyView.The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng +16 more
wiley +1 more source
Cell Reports, 2018 Summary: How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved.
Wen-jie Du +9 more
doaj
Anesthesia and Analgesia, 1993 The mechanism(s) of action of anesthetics on cell membrane ionic currents are not known. To investigate this further the effects of clinically relevant concentrations of ketamine, methohexital, and propofol on the delayed rectifier (IK) and the inward ...
V. Baum
semanticscholar +1 more source
Advanced Science, EarlyView.Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He +6 more
wiley +1 more source
Romiplostim use in pregnant women with immune thrombocytopenia
American Journal of Hematology, Volume 98, Issue 1, Page 31-40, January 2023., 2023 Abstract Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before ...
James B. Bussel +7 more
wiley +1 more source
On drug transport after intravenous administration [PDF]
arXiv, 2011 A mathematical model of a drug transport after rapid injection is given. It takes into account three processes: - drug plasma protein binding in central compartment - transport processes between the central compartment and the peripheral compartment - elimination of a drug from the central compartment. .
arxiv
Direct Effects of Intravenous Anesthetics on Pulmonary Vascular Resistance in the Isolated Rat Lung
Anesthesia and Analgesia, 1994 We determined the direct effects of thiopental, ket-amine, midazolam, etomidate, and propofol on pulmonary vascular resistance (PVR), the relationship of the direct effects to the baseline PVR, and the possible interaction with functional endothelium ...
G. Rich +4 more
semanticscholar +1 more source
Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA
Advanced Science, EarlyView.In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa +5 more
wiley +1 more source