Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Effect of the combination of remifentanil and neuromuscular blockers in pediatric endotracheal intubation: a prospective, double-blinded, randomized clinical trial. [PDF]
BMC PediatrQiao L +6 more
europepmc +1 more source
Advanced Science, EarlyView.Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera +12 more
wiley +1 more source
Low-Dose Ropivacaine-Fentanyl Spinal Anesthesia Combined with Carbetocin for Cesarean Section: A Randomized Double-Blind Non-Inferiority Trial. [PDF]
J Pain ResLi M, Xie G, Chu L, Lu Y, Xu T, Li Y.
europepmc +1 more source
Advanced Science, EarlyView.In this study, an “all‐in‐one” engineered anaerobic bacterial system (PDAEcN/COS) is developed for the treatment of immunologically “cold” TNBC. This nanoplatform is capable of colonizing tumor cell surfaces and implementing “self‐blocking” of immune checkpoints, while simultaneously suppressing tumor cells' “don't eat me” signals and delivering “eat ...
Xuanxiang Zhai +6 more
wiley +1 more source
Effect of Intravenous Lidocaine (1.0 mg/Kg) on Propofol ED50 and ED95 for Successful Double-Lumen Laryngeal Mask Airway Placement in Hysteroscopy Patients: A Randomized Controlled Trial. [PDF]
Drug Des Devel TherZhang J, Li J, Ni J.
europepmc +1 more source
Advanced Science, EarlyView.This study proposes for the first time that hepatic GSDMD plays a key protective role in sepsis. Hepatic GSDMD may release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of septic mice ...
Yihan Qian +9 more
wiley +1 more source
Comparison of Postoperative Analgesic Effects of Intravenous versus Perineural Dexamethasone Injection Combined with Ropivacaine in Thoracoscopy-Guided Thoracic Paravertebral Block for Thoracoscopic Radical Lung Cancer Resection: A Prospective Randomized Controlled Trial. [PDF]
Drug Des Devel TherWu KW +4 more
europepmc +1 more source
Advanced Science, EarlyView.A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri +16 more
wiley +1 more source