Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, EarlyView.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Effects of Adding Local Anesthesia to General Anesthesia on Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: A Retrospective Cohort Study. [PDF]
J Pain ResZhong L, Wang R, Huang L.
europepmc +1 more source
Total Intravenous Anesthetic Versus Inhaled Anesthetic: Pick Your Poison
Anesthesia & Analgesia, 2019 Jodi D, Sherman, Brian, Barrick
openaire +3 more sources
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Prophylactic Use of Lipid Emulsion Therapy After Inadvertent Administration of 0.5% Ropivacaine for a Bier Block: A Case Report. [PDF]
Case Rep AnesthesiolLuong A +7 more
europepmc +1 more source
Advanced Science, EarlyView.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral +7 more
wiley +1 more source
Impact of the Combination of Remimazolam and Volatile Anesthetics on Circulatory Dynamics in Free-Flap Reconstruction Surgery for Oral Cancer: A Retrospective Comparison With Desflurane and Sevoflurane. [PDF]
CureusSasaki Y, Nakagawa H, Kitamura A.
europepmc +1 more source
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source
Roles of anesthetics in modulating neutrophil extracellular traps formation: a review of current literature. [PDF]
Ann Med Surg (Lond)Alsabani MH.
europepmc +1 more source
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source