The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase.
Graesboll, Kaare +2 more
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General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics. [PDF]
Pharmaceuticals (Basel)The introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Čižmáriková R +2 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: The degree of hepatic ischemia-reperfusion injury (HIRI) is highly relevant to the incidence of postoperative liver failure and mortality.
Jiayu Feng +5 more
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The free energy of biomembrane and nerve excitation and the role of anesthetics [PDF]
BBA - Biomembranes 1860 (2018) 2145-2153, 2018 In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference ...
Heimburg, Thomas +3 more
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Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer. [PDF]
Front PharmacolCervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the
Deng L, Wang T, Zhang Q, Shu S, Chen X.
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Inhalational versus intravenous anesthetic for cerebrovascular accident outcomes after surgical revascularization for adult moyamoya disease. [PDF]
BMC AnesthesiolPurpose To compare the effects of inhalational anesthetics and intravenous anesthetics on the neurological function of patients with moyamoya disease (MMD) after vascular bypass surgery.
Cheng Y, Zha C, Che X, Wang Y.
europepmc +2 more sources
Effects of anesthetics on development of gynecological cancer. [PDF]
Front Cell Dev BiolGynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period.
Cheng Y, Wu Y, Xu L.
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Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial. [PDF]
TrialsBackground Postoperative cognitive dysfunction (POCD) is one of the major complications after surgery, with devastating clinical outcomes. Although POCD is a condition with a multifactorial pathophysiology, blood-brain barrier (BBB) dysfunction and ...
Wi W +5 more
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Intravenous anesthetics have differential effects on human potassium channels. [PDF]
Acta Biochim Biophys Sin (Shanghai)General anesthetics are widely used in the clinic and greatly promote the development of surgery. However, the incidence of cardiovascular and respiratory complications caused by general anesthetics is still high, and the underlying mechanisms remain ...
Tao Y +9 more
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Total intravenous anesthesia for liver resections: anesthetic implications and safety [PDF]
Korean Journal of Anesthesiology, 2022 Inhalational anesthetics have been the default agents for general anesthesia maintenance for several decades. However, with advances in total intravenous anesthesia (TIVA) and a growing body of evidence on the potential benefits of TIVA ...
Selene Yan Ling Tan, Nian Chih Hwang
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