Results 201 to 210 of about 40,984 (314)

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Application and research progress of tranexamic acid in the perioperative period of posterior lumbar interbody fusion. [PDF]

Front Med (Lausanne)
Dong W, Tang Y, Zhou Y, Li J, Wu C, Liu Y, Yan Y, Peng Z, Zhao J.   +8 more
europepmc   +1 more source

A Pill That Prints‐An Ingestible Bioprinter for Non‐Invasive Structured Bioink Deposition

Advanced Science, EarlyView.
A first‐of‐a‐kind swallowable bioprinter performs in‐situ bioink deposition and patterning directly over disease sites without tethers, electronics, or invasive surgery. Combining magnetic guidance with near‐infrared triggering enables functionality within a small footprint.
Sanjay Manoharan, Vivek Subramanian
wiley   +1 more source

Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies

Advanced Science, EarlyView.
Precision targeting of the spleen and myeloid cells of the tumor microenvironment, with minimal hepatic delivery, is achieved using a modular peptide dendrimer‐lipid nanocarrier. Functional assays, transcriptomics, and rodent models validate this novel myeloid cell targeting nanocarrier as an efficacious immunotherapy, both as a cancer vaccine platform
Lawrence James Billing, Liam Martin, Tristan Henser‐Brownhill, Parisa Samangouei, Adam Leach, Phoebe Knight, Marina Apostolidou, Aaqib Ladak, Benita Nagel, Albert Kwok   +9 more
wiley   +1 more source

Successful sedation with remimazolam and alfentanil in a child susceptible to malignant hyperthermia: a case report. [PDF]

BMC Anesthesiol
Zhu K, Wu S, Hao X, Wang C.
europepmc   +1 more source

Long‐Term Stable Subdural Recordings Enabled by Fibrosis‐Resistant Hydrogel‐Integrated µECoG Arrays

Advanced Science, EarlyView.
An adhesive hydrogel‐integrated micro‐electrocorticography (aGel‐µECoG) array is developed to ensure stable neural recordings by minimizing neuroinflammation and fibrosis during implantation. The hydrogel serves as a biological and mechanical bridge, enabling bioadhesive, reversible, anti‐fibrotic integration with brain tissue.
Lin Chen, Hao Zhong, Linghao Wang, Liju Xu, Wanying Fan, Yongpeng Zhao, Huiling Zhang, Yang Shen, Kai Wu, Xin Fu, Jingxiang Guo, Ke Li, Dong Qiu, Ting Wu   +13 more
wiley   +1 more source

Impact of temperature on EC₅₀ of ropivacaine in axillary brachial plexus blocks: based on Dixon's up-and-down method. [PDF]

Front Med (Lausanne)
Wang A, Shao Y, Zheng Y, Li X, Huang B, Mai Y, Zhang Z.   +6 more
europepmc   +1 more source

Efficacy of Sequential Hepatic Vein Embolization Following Portal Vein Embolization in Promoting Regeneration of Liver Volume and Function Before Right‐Sided Major Hepatectomy

Annals of Gastroenterological Surgery, EarlyView.
Sequential hepatic vein embolization (HVE) following portal vein embolization (PVE) significantly improves both the volume and function of the future remnant liver (FRL) compared to PVE alone. In this study, the FRL regeneration rates for volume and function were markedly higher and faster in the PVE–HVE group, with no differences in surgical outcomes ...
Thanh Tung Lai, Kosuke Matsui, Hideyuki Matsushima, Hidekazu Yamamoto, Gozo Kiguchi, Hisashi Kosaka, Van Khanh Nguyen, Yasuhiro Ueno, Shuji Kariya, Masaki Kaibori   +9 more
wiley   +1 more source

Effects of sevoflurane inhalation anesthesia versus propofol intravenous anesthesia on postoperative cognitive function in patients with malignant tumors: A meta-analysis. [PDF]

Medicine (Baltimore)
Quan Y, Zhang M, Zheng M, Zhao M, Lv Z, Liu G.   +5 more
europepmc   +1 more source