Results 51 to 60 of about 242,397 (299)

Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial

Trials
Background Postoperative cognitive dysfunction (POCD) is one of the major complications after surgery, with devastating clinical outcomes. Although POCD is a condition with a multifactorial pathophysiology, blood-brain barrier (BBB) dysfunction and ...
Wongook Wi, Hyo-Jin Kim, Sira Bang, Oh Joo Kweon, Doyeon Kim, Eun Jung Oh   +5 more
doaj   +1 more source

Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Frontiers in Pharmacology
Cervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the
Linyan Deng, Linyan Deng, Linyan Deng, Tingting Wang, Tingting Wang, Tingting Wang, Qiaofeng Zhang, Qiaofeng Zhang, Qiaofeng Zhang, Shaofang Shu, Shaofang Shu, Shaofang Shu, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +14 more
doaj   +1 more source

The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism

Cell Reports, 2018
Summary: How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved.
Wen-jie Du, Rong-wei Zhang, Jia Li, Bai-bing Zhang, Xiao-lan Peng, Song Cao, Jie Yuan, Cheng-dong Yuan, Tian Yu, Jiu-lin Du   +9 more
doaj   +1 more source

Role of magnesium sulfate in the treatment of acute postoperative pain [PDF]

Arhiv za farmaciju, 2019
Co-analgesics are often combined with opioids to reduce the prevalence of opioid adverse effects while maintaining or even improve the quality of analgesia.
Vučković Sonja, Savić-Vujović Katarina, Srebro Dragana, Jovanović Lepa, Prostran Milica   +4 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Systemic immune effects of anesthetics and their intracellular targets in tumors

Frontiers in Medicine, 2022
According to the result released by the World Health Organization (WHO), non-communicable diseases have occupied four of the top 10 current causes for death in the world.
Ting Luan, Yi Li, Lihui Sun, Lihui Sun, Siqi Xu, Siqi Xu, Haifeng Wang, Jiansong Wang, Chong Li, Chong Li   +9 more
doaj   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Relationship between volatile anesthetics and functional outcomes in patients with subarachnoid hemorrhage

Journal of Anesthesia, Analgesia and Critical Care
Background Volatile anesthetics have been suggested to exert neuroprotective effects in patients with subarachnoid hemorrhage caused by a ruptured cerebral aneurysm. However, their effects on functional outcomes remain unverified.
Yudai Iwasaki, Kunio Tarasawa, Yu Kaiho, Saori Ikumi, Takahiro Imaizumi, Shizuha Yabuki, Kiyohide Fushimi, Kenji Fujimori, Masanori Yamauchi   +8 more
doaj   +1 more source

Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo

, 2008
Objectives: Here we evaluated the in vitro and in vivo effects of the intravenous anesthetics, etomidate, propofol, and ketamine, on the activity of human serum paraoxonase (hPON1)
Ekinci, Deniz, Beydemir, Suekrue, ALICI, Haci Ahmet   +2 more
core   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source