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The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase.
Graesboll, Kaare +2 more
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, 2020 The fascinating history of local anesthetics (LAs) began in South America with the herbal and traditional use of cocaine leaves by the indigenous peoples of Peru and Bolivia, the sacred plant of the Incas Erythroxylum coca.
Cárdenas-Maytorena, Ana C. +3 more
core +4 more sources
Knowledge and awareness about local anesthetics used in endodontic procedures among dental students [PDF]
, 2022 Introduction: Local anesthetics are a special group of drugs that cause reversible loss of sensation. They are the most commonly used drug in dentistry.
Imtiaz, Taanya, Khandelwal, Akshay
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Topics in Local Anesthetics [PDF]
, 2021 The fascinating history of local anesthetics was born in the Andean Mountains with the use of Erythroxylum coca and has gradually evolved into a group of safe drugs in anesthesiology and pain medicine.
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Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review [PDF]
, 2022 There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases.
Aguirre, José, Borgeat, Alain
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Anais Brasileiros de Dermatologia, 2020 Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic ...
Ana Carolina Figueiredo Pereira Cherobin +1 more
openaire +6 more sources
Local anesthetics for the Nephrologist [PDF]
Clinical Kidney Journal, 2021 Abstract Several specialists in medicine use local anesthetics. In patients with kidney disease, these agents are used during catheter insertions for hemodialysis and peritoneal dialysis, arteriovenous fistula and graft procedures, kidney transplantation, parathyroidectomy, kidney biopsies, and dental and skin procedures.
Nupur N Uppal +5 more
openaire +2 more sources
Lipid Emulsion for Local Anesthetic Systemic Toxicity [PDF]
, 2012 The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Ciechanowicz, Sarah, Patil, Vinod
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Adjuvant Drugs to Local Anesthetics [PDF]
, 2020 Local anesthetics have a potential to be used in a wide variety of situations including central neuraxial blocks, peripheral nerve blocks, intravenous, and local infiltration both for surgeries and acute and chronic pain management.
Mehta, Nandita +1 more
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Benzonatate as a local anesthetic
PLOS ONE, 2023 Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will ...
Anna McGuire +4 more
openaire +4 more sources