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Safety of local anesthetics, [PDF]
Anais Brasileiros de Dermatologia, 2020 Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types.
Ana Carolina Figueiredo Pereira Cherobin +1 more
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Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication? [PDF]
Therapeutic Advances in Drug SafetyThe increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas +4 more
doaj +2 more sources
Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]
Jichu yixue yu linchuang, 2022 Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
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Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer
Frontiers in Oncology, 2022 Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang +9 more
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Stem Cell Research & Therapy, 2021 Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local
Xiaoqing Fan +7 more
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BMC Anesthesiology, 2020 Background Retrospective analysis and pre-clinical studies suggest that local anesthetics have anti-tumoral effects. However, the association between cancer recurrence and the use of local anesthesia is inconclusive and most reports are based on single ...
Guanhua Zhu +3 more
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Mechanisms of Cancer Inhibition by Local Anesthetics
Frontiers in Pharmacology, 2021 The use of local anesthetics during surgical treatment of cancer patients is an important part of perioperative analgesia. In recent years, it has been showed that local anesthetics can directly or indirectly affect the progression of tumors.
Yiguo Zhang +7 more
doaj +1 more source
Local anesthetics for the Nephrologist [PDF]
Clinical Kidney Journal, 2021 Abstract Several specialists in medicine use local anesthetics. In patients with kidney disease, these agents are used during catheter insertions for hemodialysis and peritoneal dialysis, arteriovenous fistula and graft procedures, kidney transplantation, parathyroidectomy, kidney biopsies, and dental and skin procedures.
Nupur N Uppal +5 more
openaire +2 more sources
Benzonatate as a local anesthetic
PLOS ONE, 2023 Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will ...
Anna McGuire +4 more
openaire +4 more sources
The thermodynamics of general and local anesthesia [PDF]
, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase.
Graesboll, Kaare +2 more
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