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Safety of local anesthetics, [PDF]

Anais Brasileiros de Dermatologia, 2020
Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types.
Ana Carolina Figueiredo Pereira Cherobin, Glaysson Tassara Tavares   +1 more
doaj   +7 more sources

Mechanisms of Cancer Inhibition by Local Anesthetics

Frontiers in Pharmacology, 2021
The use of local anesthetics during surgical treatment of cancer patients is an important part of perioperative analgesia. In recent years, it has been showed that local anesthetics can directly or indirectly affect the progression of tumors.
Yiguo Zhang, Yixin Jing, Rui Pan, Ke Ding, Rong Chen, Rong Chen, Qingtao Meng, Qingtao Meng   +7 more
doaj   +2 more sources

Differential effects and mechanisms of local anesthetics on esophageal carcinoma cell migration, growth, survival and chemosensitivity

BMC Anesthesiology, 2020
Background Retrospective analysis and pre-clinical studies suggest that local anesthetics have anti-tumoral effects. However, the association between cancer recurrence and the use of local anesthesia is inconclusive and most reports are based on single ...
Guanhua Zhu, Ling Zhang, Jiapeng Dan, Qiong Zhu   +3 more
doaj   +2 more sources

Local anesthetics elicit immune-dependent anticancer effects

Journal for ImmunoTherapy of Cancer, 2022
Background Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery. Here, we investigated the anticancer effects of six local anesthetics used in
Shuai Zhang, Peng Liu, Wei Xie, Fabrice Barlesi, Guido Kroemer, Oliver Kepp, Juliette Humeau, Jonathan Pol, Liwei Zhao, Lucillia Bezu, Alejandra Wu Chuang, Allan Sauvat, Giulia Cerrato, Julie Le Naour, Peter van Endert   +14 more
doaj   +2 more sources

Effects of local anesthetics on breast cancer cell viability and migration

BMC Cancer, 2018
Background Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery.
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P. Dilger, Jun Lin   +5 more
doaj   +2 more sources

Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication? [PDF]

Therapeutic Advances in Drug Safety
The increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas, Janet Cristina Vázquez-Beltrán, María Soledad Romero-López, Oscar Olvera-Montaño, Lourdes Yolotzin Rodríguez-Herrera   +4 more
doaj   +2 more sources

Solvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy [PDF]

Molecules
Local anesthetics have been widely used in clinical analgesia due to their ability to provide effective regional pain management. Accurate measurement of local anesthetics in body fluids is crucial for ensuring patient medication safety and optimizing ...
Huimin Sui, Miao Li, Yangyang Gao, Jie Luo, Fangyuan Ban, Tao Xu, Shuang Fu, Chao-Yang Zhao, Hailin Wen, Cuiyan Han   +9 more
doaj   +2 more sources

Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects

Anesthesiology Research and Practice, 2013
Despite a long history in medical and dental application, the molecular mechanism and precise site of action are still arguable for local anesthetics. Their effects are considered to be induced by acting on functional proteins, on membrane lipids, or on ...
Hironori Tsuchiya, Maki Mizogami
doaj   +2 more sources

Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]

Jichu yixue yu linchuang, 2022
Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
doaj   +1 more source

Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer

Frontiers in Oncology, 2022
Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang, Alejandra Wu Chuang, Oliver Kepp, Oliver Kepp, Guido Kroemer, Guido Kroemer, Guido Kroemer, Lucillia Bezu, Lucillia Bezu, Lucillia Bezu   +9 more
doaj   +1 more source