Results 91 to 100 of about 72,477 (285)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Bupivacaína racêmica a 0,5% e mistura com excesso enantiomérico de 50% (S75-R25) a 0,5% no bloqueio do plexo braquial para cirurgia ortopédica. Estudo comparativo Bupivacaína racémica a 0,5% y mezcla con exceso enantiomérico del 50% (S75-R25) a 0,5% en el bloqueo del plexo braquial para cirugía ortopédica. Estudio comparativo Comparative study of 0.5% racemic bupivacaine versus enantiomeric mixture (S75-R25) of 0.5% bupivacaine in brachial plexus block for orthopedic surgery

Revista Brasileira de Anestesiologia, 2005
JUSTIFICATIVA E OBJETIVOS: Com a finalidade de encontrar uma droga mais segura que a bupivacaína racêmica, vários estudos foram realizados com seus isômeros.
Roberto Tsuneo Cervato Sato, Douglas Flávio Porsani, Antônio Garibaldino Vieira do Amaral, Oscar Vilmar Schulz Júnior, Ângelo Manoel Grande Carstens   +4 more
doaj   +1 more source

Advances of Nano-Structured Extended-Release Local Anesthetics

Nanoscale Research Letters, 2020
Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs.
Yumiao He, Linan Qin, Yuguang Huang, Chao Ma   +3 more
doaj   +1 more source

Cardiac arrest in a child during a combined general epidural anesthesia procedure [PDF]

, 2005
An increased risk of perioperative cardiac arrest in children, in comparison to adults, has been recognized. A number of factors associated with perioperative cardiac arrest have been identified, including young age, comorbidities, and emergency ...
Prabakti, Yudhi, Siahaan, Edwin MP, Sidhartani,, M, Soemantri,, A, Soenarjo, Soenarjo   +4 more
core  

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

Advanced Functional Materials, EarlyView.
Platinum‐Copper bimetallic nanoparticles may evolve depending on their synthesis under tumor microenvironment conditions and play a dual role as chemotherapeutic agents after releasing Cu ions and as near infrared photothermal agents with the Pt‐rich remaining frames.
Jose I. Garcia‐Peiro, María Sancho‐Albero, Silvia Miguel, Andrea Mosseri, Felipe Hornos, Rafael Contreras‐Montoya, Jose L. Hueso, Jesus Santamaria   +7 more
wiley   +1 more source

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]

, 2019
BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S., Hu, Jia, Lee, Gwo-Chin, Pollack, Richard A., Viscusi, Eugene R.   +4 more
core   +1 more source

Ten Years of Experience Training Non-Physician Anesthesia Providers in Haiti. [PDF]

, 2009
Surgery is increasingly recognized as an effective means of treating a proportion of the global burden of disease, especially in resource-limited countries. Often non-physicians, such as nurses, provide the majority of anesthesia; however, their training
AF Ouro-Bang’na Maman, AF Smith, BL Grundy, D Hansen, D Ozgediz, DC Simonson, F Mullan, F Mullan, I Walker, IA Walker, JP Abenstein, K Chu, KA Torgersen, Kathryn Chu, LC Ivers, M Philips, M Zimmerman, Miguel Trelles, MN Cherian, MS McAuliffe, Nathan Ford, Organization PAH, P Adnet, P Chatterjee, PE Farmer, Peter Rosseel, S Jochberger, SC Hodges, Seydouba Guilavogui, T Lokossou, TG Weiser, WA Tweed   +31 more
core   +2 more sources

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

Local anesthetics induce autophagy in young permanent tooth pulp cells [PDF]

, 2015
Pulp cells are essential for tooth development, and dentin repair and regeneration. In addition these cells have been identified as an important stem cell source.
Ali, K, Ardu, S, Hu, B, Hu, D, Luo, S, Nisr, RB, Singer, D, Tieu, K, Tredwin, C, Walker, JV, Zhuang, H   +10 more
core   +2 more sources