Results 101 to 110 of about 305,764 (265)

Effect of Dibucaine on Phase Behavior of Ternary Liposome [PDF]

Med. Chem. Commun. 6, 1444-1451 (2015), 2014
We investigated the effect of Dibucaine hydrochloride (DC$\cdot$HCl), one of the local anesthetics, on phase behavior of ternary liposome composed of dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), and cholesterol (Chol). The large DOPC/DPPC/Chol liposome, that is directly observable by optical microscope, is commonly known ...
arxiv  

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Upconversion Nanoparticle‐Covalent Organic Framework Core–shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging

Advanced Materials, EarlyView.
Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim, Paul Wrede, Andrés Rodríguez‐Camargo, Yi Chen, Nihal Olcay Dogan, Chaim Glück, Bettina V. Lotsch, Daniel Razansky, Metin Sitti   +8 more
wiley   +1 more source

Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications

Advanced Materials, EarlyView.
A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung, Jamal Abu Shihada, Simon Decke, Lina Koschinski, Peter Severin Graff, Sebastián Maruri Pazmino, Anke Höllig, Henner Koch, Simon Musall, Andreas Offenhäusser, Viviana Rincón Montes   +10 more
wiley   +1 more source

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

LOCAL ANESTHETICS INDUCED ALLERGIC REACTIONS AND CONFOUNDING FACTORS

Romanian Journal of Oral Rehabilitation, 2019
The local anesthetics (LAs) immediate-type allergy is considered extremely rare by allergists. However, many health care practitioners and patients overestimate the risk of LA allergy and its potential of cross-reactivity.
Andrei Gheorghe Vicovan, Irina Teodora Cernescu, Liliana Vereș, Irina Gradinaru, Cristina Mihaela Ghiciuc   +4 more
doaj  

Trial watch: local anesthetics in cancer therapy

OncoImmunology
Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu   +3 more
doaj   +1 more source

Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia [PDF]

arXiv
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-aminobutyric acid (GABA) receptors, the primary inhibitory receptors in the central nervous system, could
arxiv  

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Advanced Materials, EarlyView.
Dynamic nanoscale groove‐ridge structures are engineered by flexibly conjugating RGD‐magnetic nanoparticles to nanogroove templates with variable groove widths at the molecular scale. Magnetic control enables cyclic switching between nanoscale groove and ridge states that modulates ligand accessibility of cellular integrins.
Hyunsik Hong, Dahee Kim, Hwapyung Jung, Seongyeol Kim, Sunhong Min, Chowon Kim, Kanghyeon Kim, Hyunji Rha, Heemin Kang   +8 more
wiley   +1 more source

Ultrasound matrix imaging for transcranial in-vivo localization microscopy [PDF]

arXiv
Transcranial ultrasound imaging is usually limited by skull-induced attenuation and high-order aberrations. By using contrast agents such as microbubbles in combination with ultrafast imaging, not only can the signal-to-noise ratio be improved, but super-resolution images down to the micrometer scale of the brain vessels can be obtained.
arxiv