Results 131 to 140 of about 73,932 (262)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Anatomy of Soft Tissues of the Spinal Canal [PDF]

, 1999
Background and Objectives. Important issues regarding the spread of solutions in the epidural space and the anatomy of the site of action of spinal and epidural injections are unresolved.
Quinn, Hogan, Toth, Jeffrey M.
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair

Advanced Healthcare Materials, EarlyView.
Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee   +5 more
wiley   +1 more source

Battery‐Free Dual‐Channel Wireless Neurostimulator Using Passive Circuitry for Neuropathic Pain Modulation

Advanced Healthcare Materials, EarlyView.
A compact, wireless neural stimulator featuring a novel tapping inductor enables selective and independent stimulation of the motor cortex in rats via a single receiver coil. This minimally invasive system effectively reduces neuropathic pain through targeted cortical activation, offering a new avenue for bioelectronic pain therapies and advancing ...
Jeongju Moon, Kyungmo Seong, Hyeon Gyu Kim, Wonki Mun, Seung Hyun Min, Sung‐Yun Park, Joonsoo Jeong, Chin Su Koh, Hyun Ho Jung, Kyungsik Eom   +9 more
wiley   +1 more source

Synthetic Hydrogels Incorporating Hydrolytic/Nonhydrolytic Macromer Ratios Exhibit Improved Tunability of In Vivo Degradation and Immune Responses

Advanced Healthcare Materials, EarlyView.
A synthetic 4‐arm maleimide‐terminated poly(ethylene glycol) (PEG‐4MAL) hydrogel system that combines hydrolytic ester‐linked macromer (PEG‐4eMAL) with nondegradable amide‐linked macromer (PEG‐4aMAL) in various stoichiometric ratios to tune the degradability rate. The macromers are crosslinked with dithiothreitol via thiol‐maleimide click reaction. The
Michael D. Hunckler, Sophia Kioulaphides, Karen E. Martin, Angelica L. Torres, Graham F. Barber, Stephen W. Linderman, Rebecca S. Schneider, Andrés J. García   +7 more
wiley   +1 more source

Co‐Delivery of Ca‐MOF and Mg‐MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis

Advanced Healthcare Materials, EarlyView.
Metal‐organic frameworks (MOFs) have been synthesized using calcium (Ca‐MOF), magnesium (Mg‐MOF), and as hybrids (Ca/Mg‐MOF) for bone healing applications. MOFs are integrated into hydrogel polymer networks for injectable, sprayable, and coating applications.
Cho‐E Choi, Chao Liang, Yasmeen Shamiya, Sang Jin Lee, Arghya Paul   +4 more
wiley   +1 more source

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

Advanced Healthcare Materials, EarlyView.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon, Sang‐Yoon Han, Ji Suk Choi, Soojeong Choi, Dongkyun Shin, Mikyung Shin, Seong Keun Kwon, Seung‐Woo Cho   +7 more
wiley   +1 more source

Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Injectable POEGMA‐DA hydrogels, dual‐crosslinked via dopamine self‐polymerization and dynamic hydrazone bonds, provide a safer alternative to invasive wound closure methods and toxic bioadhesives. Mimicking skin‐like mechanics, they achieve effective tissue adhesion for acute dermal wounds, supporting improved healing outcomes, including reducing ...
Gurpreet Kaur Randhawa, Meghan Kostashuk, Zhicheng Pan, Nils Nordstrom, Thomas Kalab, Erica Winterhelt, Todd Hoare   +6 more
wiley   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source