Results 11 to 20 of about 4,951,297 (306)
Stem Cell Research & Therapy, 2021 Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local
Xiaoqing Fan +7 more
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Analgesic protocol for procedural pain treatment of second-degree burns in children [PDF]
Vojnosanitetski Pregled, 2023 Background/Aim. Children with burns are submitted to multiple painful and anxiety-related procedures during the change of wound dressing, treatment, and rehabilitation.
Komarčević Aleksandar +4 more
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Local anesthetics for the Nephrologist [PDF]
Clinical Kidney Journal, 2021 Abstract Several specialists in medicine use local anesthetics. In patients with kidney disease, these agents are used during catheter insertions for hemodialysis and peritoneal dialysis, arteriovenous fistula and graft procedures, kidney transplantation, parathyroidectomy, kidney biopsies, and dental and skin procedures.
Nupur N Uppal +5 more
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Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends
Saudi Journal of Anaesthesia, 2020 In recent anesthetic practice, peripheral nerve blocks (PNBs) are used extensively for surgical anesthesia and nonsurgical analgesia. PNBs offer many benefits over other anesthetic techniques in a certain population of patients, and in some specific ...
G. Krishna Prasad +2 more
semanticscholar +1 more source
Nature Communications, 2020 An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable.
Wei Zhang +7 more
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Benzonatate as a local anesthetic
PLOS ONE, 2023 Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will ...
Anna McGuire +4 more
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Neurotoxicity of local anesthetics in dentistry
Journal of dental anesthesia and pain medicine, 2020 During dental treatment, a dentist usually applies the local anesthesia. Therefore, all dentists should have expertise in local anesthesia and anesthetics. Local anesthetics have a neurotoxic effect at clinically relevant concentrations.
Eun-Jung Kim, H. Kim, Ji-Hye Ahn
semanticscholar +1 more source
Chiral Aspects of Local Anesthetics
Molecules, 2020 Thanks to the progress made in chemical technology (particularly in the methodologies of stereoselective syntheses and analyses) along with regulatory measures, the number of new chiral drugs registered in the form of pure enantiomers has increased over ...
Ružena Čižmáriková +4 more
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Pain, 2018 Cocaine is a naturally occurring compound indigenous to the Andes Mountains, West Indies, and Java. It was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived.
Carrie Schroeder, Kristopher Schroeder
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The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
arxiv +1 more source