Results 231 to 240 of about 71,118 (285)

The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells. [PDF]

Int J Mol Sci
Chen JL, Liu ST, Wu CC, Chen YC, Huang SM.   +4 more
europepmc   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Consideration of Anesthesia Techniques for Deep Brain Stimulation Implantation in the Treatment of Drug-Resistant Epilepsy: A Narrative Review. [PDF]

Biomolecules
Kaye AD, Esneault B, Deshpande S, Wentling J, Ahmadzadeh S, Potharaju P, Shekoohi S.   +6 more
europepmc   +1 more source

Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

Advanced Science, EarlyView.
The work constructs a glucose‐triggered gel for diabetic abscess treatment. The results demonstrate that the gel catalyzes glucose into oxygen, alleviates the hypoxia, and ensures sufficient ROS generation to combat pathogenic bacteria. Simultaneously, borneol within the gel can enhance the antibacterial activity of ROS and alleviate pain in patients ...
Bin Huang, Honglin An, Jianfeng Chu, Shiqi Ke, Jing Ke, Yiman Qiu, Jieping Zhang, Hanqi Zhu, Jiahui Lin, Minguang Yang, Dongliang Yang, Xuejiao Song, Weilin Liu   +12 more
wiley   +1 more source

Spinal segmental myoclonus following ultrasound-guided suprascapular nerve block: A case report. [PDF]

Turk J Phys Med Rehabil
Er G, Akan O, Koman F, Demirhan E, Kuru Ö.   +4 more
europepmc   +1 more source

Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain

Advanced Science, EarlyView.
Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang, Xiuru Ji, Yu Sun, Han Wang, Ting Wang, Tao Luo, Yanyong Cheng, Jia Yan, Dalong Ni, Hong Jiang   +9 more
wiley   +1 more source

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

Advanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng‐Ming (Spring) Kong, Gen Yang   +14 more
wiley   +1 more source

The effect of rubber dam on objective and subjective parameters of stress during dental treatment in children: a randomized clinical trial. [PDF]

BMC Oral Health
Kucukyilmaz E, Ozdemir T, Savas S.
europepmc   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source