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Local Anesthetics

2014
The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of relevant publications from January 2012 to June 2013
Sekandarzad, Mir Wais, Schug, Stephan A.
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Local Anesthetic Facelift

Facial Plastic Surgery Clinics of North America, 2020
A thorough medical history is critical in patient selection for local anesthesia facelifting. Patients with no prior issues with dental procedures and no history of significant anxiety are better candidates. Simplifying local anesthesia mixtures and using dilute concentrations will minimize dosing errors and decrease risk of local anesthesia toxicity ...
Louis M, DeJoseph, Jason D, Pou
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Local Anesthetics

Emergency Medicine Clinics of North America, 1992
Emergency physicians often rely on the use of local anesthetic agents to relieve patient discomfort, and research continues in an effort to develop new agents with improved anesthetic qualities. Eventually, a nontoxic, rapidly acting agent may become available that could provide profound anesthesia of long duration when applied topically to intact skin
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ABSORPTION OF LOCAL ANESTHETICS

Journal of the American Medical Association, 1958
Factors that determine the rate of absorption of a local anesthetic were studied in canine and, when possible, in human subjects. The drugs used were tetracaine, cocaine, procaine, and benzocaine. Objective data was obtained in the form of actual concentrations of each drug in the blood, and the concentrations obtained by intravenous injection were ...
D, CAMPBELL, J, ADRIANI
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The Pharmacology of Local Anesthetics

Veterinary Clinics of North America: Equine Practice, 1991
Understanding of the pharmacology of local anesthesia is important for selection of a local anesthetic for use in equine standing surgery. In general, the action potential is inhibited by local anesthetics by preventing the influx of sodium ions across the axonal membrane.
T K, Day, R T, Skarda
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Allergy to Local Anesthetics

JAMA: The Journal of the American Medical Association, 1969
Patients frequently relate a history suggesting allergy to local anesthetic drugs which have been commonly recognized as causing dermatitis and systemic reactions. 1 However, there appears to be a wide discrepancy between the actual incidence and the emphasis placed on them by textbooks and lectures.
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Reactions to Local Anesthetics

JAMA: The Journal of the American Medical Association, 1966
Local anesthetics are used widely by practically all physicians, most of whom are not fully aware of the lethal potential of local anesthetics and the swiftness with which they may precipitate a catastrophe. The perineural concentration of a local anesthetic necessary to interrupt conduction in a nerve fiber is many times greater than that which a ...
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Local Anesthetic Agents

Emergency Medicine Clinics of North America, 1988
The rational selection and safe use of local anesthetic solutions is of paramount importance to the practice of emergency medicine. Such decisions are based on a sound knowledge of the pharmacology and toxicity of those agents one uses clinically in day to day practice.
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Toxicity of Local Anesthetics

New England Journal of Medicine, 1976
Local anesthetics comprise one of the most widely used classes of drugs in medicine and dentistry, with their remarkable ability to block, quickly and reversibly, the traffic of impulses through both sensory and motor nerves. Historically, the demonstration of the general anesthetic properties of diethyl ether in 1846 antedated by 38 years Koller's ...
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A Superior Local Anesthetic

Archives of Dermatology, 1957
Received for publication May 21, 1957. There are a large number of agents that are used for local anesthesia by injection. Most of them I have found have one or more objections. The most commonly used ones are procaine hydrochloride, lidocaine (Xylocaine), and hexylcaine (Cyclaine). All are used in strengths of 1% to 2%.
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