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Veterinary Clinics of North America: Large Animal Practice, 1981
Local anesthetics are used in a wide range of clinical situations to prevent acute pain and to stop or ameliorate pain produced by cancer or pain associated with chronic painful conditions. Knowledge of the pharmacology of local anesthetics is essential for their safe use and selection of specific agents to achieve intended goals.Local anesthetics are ...
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Local anesthetics are used in a wide range of clinical situations to prevent acute pain and to stop or ameliorate pain produced by cancer or pain associated with chronic painful conditions. Knowledge of the pharmacology of local anesthetics is essential for their safe use and selection of specific agents to achieve intended goals.Local anesthetics are ...
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2014
The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of relevant publications from January 2012 to June 2013
Sekandarzad, Mir Wais, Schug, Stephan A.
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The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of relevant publications from January 2012 to June 2013
Sekandarzad, Mir Wais, Schug, Stephan A.
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Regional Anesthesia and Pain Medicine, 2004
Skeletal muscle toxicity is a rare and uncommon side effect of local anesthetic drugs. Intramuscular injections of these agents regularly result in reversible myonecrosis. The extent of muscle damage is dose dependent and worsens with serial or continuous administration. All local anesthetic agents that have been examined are myotoxic, whereby procaine
Wolfgang, Zink, Bernhard M, Graf
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Skeletal muscle toxicity is a rare and uncommon side effect of local anesthetic drugs. Intramuscular injections of these agents regularly result in reversible myonecrosis. The extent of muscle damage is dose dependent and worsens with serial or continuous administration. All local anesthetic agents that have been examined are myotoxic, whereby procaine
Wolfgang, Zink, Bernhard M, Graf
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Local Anesthetics, Local Anesthetic Systemic Toxicity (LAST), and Liposomal Bupivacaine.
Anesthesiology ClinicsLocal anesthetics have played a vital role in the multimodal analgesia approach to patient care by decreasing the use of perioperative opioids, enhancing patient satisfaction, decreasing the incidence of postoperative nausea and vomiting, decreasing the ...
Michael O On'Gele +3 more
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Recent advances in polymer-based drug delivery systems for local anesthetics.
Acta Biomaterialia, 2019Local anesthetics, which cause temporary loss of pain by inhibiting the transmission of nerve impulses, have been widely used in clinical practice. However, neurotoxicity and short half-lives have significantly limited their clinical applications.
Bo Wang +10 more
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Local Anesthetics: Pharmacology and Special Preparations.
The Veterinary clinics of North America. Small animal practice, 2019Local anesthetics are the only class of drugs that can block transduction and transmission of nociception. Physical properties, mechanism of action, and pharmacokinetics of this class of drugs are reviewed in this article.
M. Barletta, R. Reed
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The American Journal of Surgery, 1957
Abstract 1. 1. An outline of the pharmacology of propoxycaine HCI, a new local anesthetic, is presented. 2. 2. Seventy-one cases in which propoxycaine HCI was used as a local anesthetic are reviewed. 3. 3. Salient features of the satisfactory performance of propoxycaine HCI include: (a) rapid onset, (b) effective in small dosage, (c ...
J H, MITCHELL +2 more
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Abstract 1. 1. An outline of the pharmacology of propoxycaine HCI, a new local anesthetic, is presented. 2. 2. Seventy-one cases in which propoxycaine HCI was used as a local anesthetic are reviewed. 3. 3. Salient features of the satisfactory performance of propoxycaine HCI include: (a) rapid onset, (b) effective in small dosage, (c ...
J H, MITCHELL +2 more
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Lipid-based carriers for the delivery of local anesthetics
Expert Opinion on Drug Delivery, 2019Introduction: There is a clinical need for pharmaceutical dosage forms devised to prolong the acting time of local anesthetic (LA) agents or to reduce their toxicity.
D. R. de Araújo +2 more
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Emergency Medicine Clinics of North America, 1992
Emergency physicians often rely on the use of local anesthetic agents to relieve patient discomfort, and research continues in an effort to develop new agents with improved anesthetic qualities. Eventually, a nontoxic, rapidly acting agent may become available that could provide profound anesthesia of long duration when applied topically to intact skin
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Emergency physicians often rely on the use of local anesthetic agents to relieve patient discomfort, and research continues in an effort to develop new agents with improved anesthetic qualities. Eventually, a nontoxic, rapidly acting agent may become available that could provide profound anesthesia of long duration when applied topically to intact skin
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The Pharmacology of Local Anesthetics
Veterinary Clinics of North America: Equine Practice, 1991Understanding of the pharmacology of local anesthesia is important for selection of a local anesthetic for use in equine standing surgery. In general, the action potential is inhibited by local anesthetics by preventing the influx of sodium ions across the axonal membrane.
T K, Day, R T, Skarda
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