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THE PHARMACOLOGY OF LOCAL ANESTHETICS
Anesthesiology Clinics of North America, 2000The pharmacology of local anesthetics is an integration of the basic physiology of excitable cells and the mechanism by which local anesthetics are capable of interrupting conduction of neural messages. The common characteristics of the molecules with local anesthetic action have been identified and can explain the properties of the agents.
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Dermatologic Clinics, 1994
Although lidocaine alone will serve as an excellent anesthetic for most patients, using less painful injectable agents, topical anesthetics, and occasionally oral sedation will offer the frightened or pain-intolerant patient an acceptable and effective alternative system of local anesthesia.
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Although lidocaine alone will serve as an excellent anesthetic for most patients, using less painful injectable agents, topical anesthetics, and occasionally oral sedation will offer the frightened or pain-intolerant patient an acceptable and effective alternative system of local anesthesia.
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Local Anesthetics: Eutectic Mixture of Local Anesthetics
1991All commonly available local anesthetics have poor skin penetration when applied topically. One of the main reasons is that a local anesthetic agent needs to be in its cationic form in order to block nerve conduction. But it is the uncharged base which penetrates and diffuses into the tissues after topical administration.
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Alkalinization of Local Anesthetics
Regional Anesthesia & Pain Medicine, 1999R, King, M, Hepp, V, Fenton-May
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