Results 71 to 80 of about 247,106 (383)
Molecular Medicine Reports, 2015 The incidence of Alzheimer’s disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia.
Jue Jiang, Hong Jiang
semanticscholar +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Scientific ReportsThe inspired sinewave technique (IST) is a non-invasive method to measure lung heterogeneity indices (including both uneven ventilation and perfusion or heterogeneity), which reveal multiple conditions of the lung and lung injury.
Minh C. Tran +8 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Study objectivePostoperative delirium (POD) is one of the serious postoperative complications in elderly patients, which is always related to long-term mortality. Anesthesia is often considered a risk factor for POD.
Xuhui Zhuang +5 more
doaj +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
THE AMOUNT OF THE ANESTHETIC. [PDF]
JAMA: The Journal of the American Medical Association, 1900 The anesthetic is undoubtedly a prominent etiologic factor in the disturbances which accompany and follow surgcal operations. To it may be attributed, directly or indirectly, much of the rapid pulse and respiration, exhaustion, shock, nausea, vomiting, asphyxia, syncope, bronchitis, pneumonia, pulmonary edema, and nephritis seen in connection with ...
openaire +3 more sources
The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics [PDF]
Biophys. J. 96 (2009), 4581-4591, 2008 We investigate the permeability of lipid membranes for fluorescence dyes and ions. We find that permeability reaches a maximum close to the chain melting transition of the membranes. Close to transitions, fluctuations in area and compressibility are high, leading to an increased likelihood of spontaneous lipid pore formation.
arxiv +1 more source
Pain management via local anesthetics and responsive hydrogels.
Therapeutic delivery, 2015 Acute and chronic pain control is a significant clinical challenge that has been largely unmet. Local anesthetics are widely used for the control of post-operative pain and in the therapy of acute and chronic pain.
Kyle R. Bagshaw +6 more
semanticscholar +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Surgical neurology international, 2015 Background: The efficacy of epidural and facet joint injections has been assessed utilizing multiple solutions including saline, local anesthetic, steroids, and others.
L. Manchikanti +13 more
semanticscholar +1 more source