Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
Cells, 2022 Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri +2 more
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A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A +8 more
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Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Cellular Oncology, 2004 Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti +3 more
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Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis. [PDF]
, 2015 Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females ...
Amor, David J +13 more
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Dosage compensation can buffer copy-number variation in wild yeast
eLife, 2015 Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy,
James Hose +5 more
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DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs.
PLoS ONE, 2017 The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations (CNAs) in oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC ...
Patrizio Castagnola +8 more
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Epigenetic consequences of interploidal hybridisation in synthetic and natural interspecific potato hybrids [PDF]
, 2019 Interploidal hybridisation can generate changes in plant chromosome numbers, which might exert effects additional to the expected due to genome merger per se (i.e., genetic, epigenetic and phenotypic novelties).Wild potatoes are suitable to address this ...
Camadro, Elsa Lucila +4 more
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Aneuploidy: implications for protein homeostasis and disease
Disease Models & Mechanisms, 2014 It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of ...
Ana B. Oromendia, Angelika Amon
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Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]
, 2018 BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J +13 more
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A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]
, 2019 Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G +3 more
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