Results 81 to 90 of about 50,865 (308)

The tolerance of aneuploidy in yeast

Genetical Research, 1970
SUMMARYSingle ascospore cultures from triploids were screened as a potential source of disomic tester stocks for the purpose of genetical mapping of chromosomes in yeast. A high tolerance of aneuploidy was found, and strains disomic for only one chromosome were rare.
Elizabeth M. Parry, Brian S. Cox
openaire   +3 more sources

DNA methylation and copy number alterations in the progression of HPV-associated high-grade vulvar intraepithelial lesion. [PDF]

Int J Cancer
What's new? Patients with human papillomavirus (HPV)‐associated high‐grade vulvar intraepithelial lesion (HSIL) often undergo damaging treatments to prevent progression to cancer. Molecular characterization of HSIL to assess progression risk could reduce the need for aggressive interventions. Here, cancer risk stratification of HSIL was investigated by
Runello F, Jary A, Duin S, Kim Y, van Eer K, Voss FO, Thuijs NB, Bleeker MCG, Steenbergen RDM.   +8 more
europepmc   +2 more sources

Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]

arXiv, 2013
We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms common to embryo stem cells and, to a lesser extent, adult stem cells, that is eventually ...
arxiv  

Distinct clinicopathological characteristics, genomic alteration and prognosis in breast cancer with concurrent TP53 mutation and MYC amplification

Thoracic Cancer, Volume 13, Issue 24, Page 3441-3450, December 2022., 2022
Breast cancer with concurrent TP53 mutation and MYC amplification demonstrated higher grade and stage, more positive HER2 status, higher Ki67 levels, and more mutations in genes involved in ERBB and TGF‐β signaling pathways, as well as exclusive FANCG/CDKN2B/QKI copy number amplifications.
Xiaoyi Lin, Xin Lin, Lijuan Guo, Yulei Wang, Guochun Zhang   +4 more
wiley   +1 more source

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Genome Biology
Background Aneuploidy, an abnormal number of chromosomes within a cell, is a hallmark of cancer. Patterns of aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues.
Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben-David, Esti Yeger-Lotem   +5 more
doaj   +1 more source

Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells

Cell Reports, 2017
Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying the physiological responses and adaptation to aneuploidy are not well understood.
Sunyoung Hwang, H. Tobias Gustafsson, Ciara O’Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres   +10 more
doaj   +1 more source

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation

Cytoskeleton, EarlyView.
ABSTRACT Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit
Saurabh S. Kulkarni, Rachel E. Stephenson, Sarah Amalraj, Angelo Arrigo, Ewelina Betleja, James J. Moresco, John R. Yates III, Moe R. Mahjoub, Ann L. Miller, Mustafa K. Khokha   +9 more
wiley   +1 more source

Chinese expert consensus on the diagnosis and treatment of HER2‐altered non–small cell lung cancer

Thoracic Cancer, Volume 14, Issue 1, Page 91-104, January 2023., 2023
To improve the diagnosis and treatment of HER2‐altered non‐small cell lung cancer in China, we reached consensus on detection strategy based on alteration type, sample selection, detection method, quality control, and treatment suggestion. Moreover, we systematically reviewed the clinical efficacy, resistance mechanisms, and development status of HER2‐
Shirong Zhang, Wenxian Wang, Chunwei Xu, Yongchang Zhang, Xiuyu Cai, Qian Wang, Zhengbo Song, Ziming Li, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Jingjing Liu, Anwen Liu, Wen Li, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Gen Lin, Long Huang, Jingping Yuan, Zhansheng Jiang, Xingxiang Pu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Hui Guo, Qian Chu, Rui Meng, Xuewen Liu, Jingxun Wu, Jin Zhou, Zhengfei Zhu, Weiwei Pan, Xiaowei Dong, Fei Pang, Kai Wang, Chao Yao, Guomin Lin, Site Li, Zhi Yang, Jiancheng Luo, Hongtao Jia, Xiuqing Nie, Liping Wang, Youcai Zhu, Xiao Hu, Yanru Xie, Xinqing Lin, Jing Cai, Yang Xia, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jing Kang, Jiatao Zhang, Chao Zhang, Wenbin Gao, Jianhui Huang, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Bing Wan, Donglai Lv, Genhua Yu, Lin Shi, Yuanli Xia, Feng Gao, Xiaochen Zhang, Tao Xu, Wei Zhou, Haixia Wang, Zhefeng Liu, Nong Yang, Lin Wu, Qiming Wang, Guansong Wang, Zhuan Hong, Jiandong Wang, Meiyu Fang, Yong Fang, Yiping Zhang, Yong Song, Shenglin Ma, Wenfeng Fang, Yuanzhi Lu   +98 more
wiley   +1 more source

Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer

Scientific Reports
Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with ...
Liam F. Spurr, Sean P. Pitroda
doaj   +1 more source

Deep Learning Models Delineates Multiple Nuclear Phenotypes in H&E Stained Histology Sections [PDF]

arXiv, 2018
Nuclear segmentation is an important step for profiling aberrant regions of histology sections. However, segmentation is a complex problem as a result of variations in nuclear geometry (e.g., size, shape), nuclear type (e.g., epithelial, fibroblast), and nuclear phenotypes (e.g., vesicular, aneuploidy). The problem is further complicated as a result of
arxiv