Results 81 to 90 of about 98,141 (333)

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +2 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems

Molecular Cytogenetics, 2018
Background In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various -omics approaches to study model systems (e.g.
Christine J. Ye, Sarah Regan, Guo Liu, Sarah Alemara, Henry H. Heng   +4 more
doaj   +1 more source

Populations of doubled haploids for genetic mapping in hexaploid winter triticale. [PDF]

, 2018
To create a framework for genetic dissection of hexaploid triticale, six populations of doubled haploid (DH) lines were developed from pairwise hybrids of high-yielding winter triticale cultivars. The six populations comprise between 97 and 231 genotyped
Baenziger, PS, Lukaszewski, AJ, Metzger, RJ, Oleszczuk, S, Ponitka, A, Rabiza-Swider, J, Tyrka, M, Wedzony, M, Wos, H, Zimny, J, Ślusarkiewicz-Jarzina, A   +10 more
core   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Adaptation to high ethanol reveals complex evolutionary pathways [PDF]

, 2015
Tolerance to high levels of ethanol is an ecologically and industrially relevant phenotype of microbes, but the molecular mechanisms underlying this complex trait remain largely unknown.
Arslan, Ahmed, Das, Anupam, De Maeyer, Dries, DeLuna, Alexander, Espinosa-Cantú, Adriana, Jelier, Rob, Kominek, Jacek, Marchal, Kathleen, Meert, Wim, van der Zande, Elisa, Van Noort, Vera, Van Pee, Michiel, Verstrepen, Kevin J, Voordeckers, Karin, Yang, Yudi, Zhu, Bp   +15 more
core   +4 more sources

Direct versus referred admission to the maternity hospital due to preeclampsia: Does it influence pregnancy outcomes?

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives This study describes maternal and perinatal outcomes of women with preeclampsia (PE) according to hospital admission characteristics: referral from lower complexity settings or directly admitted at the reference hospital. Methods This is a cross‐sectional study considering women with PE who were admitted for childbirth between ...
Juliana da‐Costa‐Santos, Guilherme F. Borges, Vitor L. V. Reis, Rodolfo R. Japecanga, Maykon A. Carvalho, Ana Julia G. Oliveira, Laura C. Vinchi, Arthur B. P. Righi, Jussara Mayrink, Fernanda G. Surita, José Paulo de Siqueira Guida, Renato T. Souza, José G. Cecatti, Maria Laura Costa   +13 more
wiley   +1 more source

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Genome Biology
Background Aneuploidy, an abnormal number of chromosomes within a cell, is a hallmark of cancer. Patterns of aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues.
Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben-David, Esti Yeger-Lotem   +5 more
doaj   +1 more source

Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. [PDF]

PLoS ONE, 2011
A change in chromosome number, known as aneuploidy, is a common characteristic of cancer. Aneuploidy disrupts gene expression in human cancer cells and immortalized human epithelial cells, but not in normal human cells.
Hisakatsu Nawata, Genro Kashino, Keizo Tano, Kazuhiro Daino, Yoshiya Shimada, Hiroyuki Kugoh, Mitsuo Oshimura, Masami Watanabe   +7 more
doaj   +1 more source

Quantifying the risk of placentally-mediated complications of pregnancy after false-positive combined screens for aneuploidy [PDF]

, 2021
Christy Pylypjuk, Bernie N. Chodirker, Chelsea Ruth, Paul Van Caeseele, Joel Monárrez Espino, Chelsea Day, Kristine Kroeker   +6 more
openalex   +1 more source