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Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the second most prevalent aortic disease following atherosclerosis, representing the ninth‐leading cause of death globally. Open surgery and endovascular procedures are
Haocheng Lu, Wa Du, Lu Ren, Milton H. Hamblin, Richard C. Becker, Y. Eugene Chen, Yanbo Fan   +6 more
doaj   +2 more sources

Blood pressure, hypertension, and the risk of aortic aneurysm in the UK Biobank [PDF]

BMC Cardiovascular Disorders
Background Although an association between elevated blood pressure and risk of aortic aneurysm is established, few studies have investigated the association with aortic aneurysm subtypes.
Rida E.Z. Naqvi, Ghaliah Baroom, Lili Zheng, Makoto Hibino, Antonio Berlanga-Taylor, Alicia K. Heath, Dagfinn Aune   +6 more
doaj   +2 more sources

Cellular Mechanisms of Aortic Aneurysm Formation

Circulation Research, 2019
Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the ...
W Robert Taylor
exaly   +2 more sources

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

Experimental and Molecular Medicine, 2019
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or endovascular repair (EVAR) is the only effective treatment for aortic aneurysm ...
Sayantan Jana, Mengcheng Shen, Zamaneh Kassiri   +2 more
exaly   +2 more sources

Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Science, 2006
Daniel P Judge, Bart L Loeys, Marc K Halushka   +2 more
exaly   +2 more sources

Pathogenesis and management of abdominal aortic aneurysm

European Heart Journal, 2023
Graphical Abstract Graphical Abstract Potential medical therapies to limit abdominal aortic aneurysm growth or rupture. VSMC, vascular smooth muscle cell; LDL, low density lipoprotein.
J. Golledge, S. Thanigaimani, J. Powell, Phillip S Tsao   +3 more
semanticscholar   +1 more source

VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia

Biomedicines, 2023
Brain arteriovenous malformations (BAVMs) are a critical concern in hereditary hemorrhagic telangiectasia (HHT) patients, carrying the risk of life-threatening intracranial hemorrhage.
Chul Han, Candice L. Nguyen, Lea Scherschinski, Tyler D. Schriber, Helen M. Arthur, Michael T. Lawton, Suk Paul Oh   +6 more
doaj   +1 more source

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Frontiers in Cardiovascular Medicine, 2022
As China’s population enters the aging stage, the threat of abdominal aortic aneurysm (AAA) mainly in elderly patients is becoming more and more serious.
Ding Wang, Ding Wang, Xinyu Hao, Xinyu Hao, Longyuan Jia, Longyuan Jia, Yuchen Jing, Yuchen Jing, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +11 more
doaj   +1 more source

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Frontiers in Physiology, 2022
Background: Abdominal aortic aneurysm (AAA) is a degenerative disease that causes health problems in humans. However, there are no effective drugs for the treatment of AAA. Artemisia annua L. (A.
Longyuan Jia, Longyuan Jia, Yuchen Jing, Yuchen Jing, Ding Wang, Ding Wang, Shuai Cheng, Shuai Cheng, Chen Fu, Xiangyu Chu, Xiangyu Chu, Chenye Yang, Chenye Yang, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +16 more
doaj   +1 more source

Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection

Frontiers in Cardiovascular Medicine, 2022
Acute aortic dissection (AAD) is a cardiovascular disease that manifests suddenly and fatally. Due to the lack of specific early symptoms, many patients with AAD are often overlooked or misdiagnosed, which is undoubtedly catastrophic for patients.
Xinyu Hao, Xinyu Hao, Shuai Cheng, Shuai Cheng, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +7 more
doaj   +1 more source