Results 1 to 10 of about 471,080 (373)

VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia

Biomedicines, 2023
Brain arteriovenous malformations (BAVMs) are a critical concern in hereditary hemorrhagic telangiectasia (HHT) patients, carrying the risk of life-threatening intracranial hemorrhage.
Chul Han, Candice L. Nguyen, Lea Scherschinski, Tyler D. Schriber, Helen M. Arthur, Michael T. Lawton, Suk Paul Oh   +6 more
doaj   +1 more source

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Frontiers in Cardiovascular Medicine, 2022
As China’s population enters the aging stage, the threat of abdominal aortic aneurysm (AAA) mainly in elderly patients is becoming more and more serious.
Ding Wang, Ding Wang, Xinyu Hao, Xinyu Hao, Longyuan Jia, Longyuan Jia, Yuchen Jing, Yuchen Jing, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +11 more
doaj   +1 more source

Through network pharmacology and molecular docking to explore the underlying mechanism of Artemisia annua L. treating in abdominal aortic aneurysm

Frontiers in Physiology, 2022
Background: Abdominal aortic aneurysm (AAA) is a degenerative disease that causes health problems in humans. However, there are no effective drugs for the treatment of AAA. Artemisia annua L. (A.
Longyuan Jia, Longyuan Jia, Yuchen Jing, Yuchen Jing, Ding Wang, Ding Wang, Shuai Cheng, Shuai Cheng, Chen Fu, Xiangyu Chu, Xiangyu Chu, Chenye Yang, Chenye Yang, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +16 more
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Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection

Frontiers in Cardiovascular Medicine, 2022
Acute aortic dissection (AAD) is a cardiovascular disease that manifests suddenly and fatally. Due to the lack of specific early symptoms, many patients with AAD are often overlooked or misdiagnosed, which is undoubtedly catastrophic for patients.
Xinyu Hao, Xinyu Hao, Shuai Cheng, Shuai Cheng, Bo Jiang, Bo Jiang, Shijie Xin, Shijie Xin   +7 more
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Comparative Assessment of Biomechanical Parameters in Subjects With Multiple Cerebral Aneurysms Using Fluid--Structure Interaction Simulations [PDF]

ASME J. Biomech. Eng. 145(5) 051003 (2023), 2022
Cerebral aneurysm progression is a result of a complex interplay of the biomechanical and clinical risk factors that drive aneurysmal growth and rupture. Subjects with multiple aneurysms are unique cases wherein clinical risk factors are expected to affect each aneurysm equally, thus allowing for disentangling the effect of biomechanical factors on ...
arxiv   +1 more source

Identification of key monocytes/macrophages related gene set of the early-stage abdominal aortic aneurysm by integrated bioinformatics analysis and experimental validation

Frontiers in Cardiovascular Medicine, 2022
ObjectiveAbdominal aortic aneurysm (AAA) is a lethal peripheral vascular disease. Inflammatory immune cell infiltration is a central part of the pathogenesis of AAA.
Shuai Cheng, Shuai Cheng, Shuai Cheng, Yuanlin Liu, Yuanlin Liu, Yuanlin Liu, Yuchen Jing, Yuchen Jing, Yuchen Jing, Bo Jiang, Bo Jiang, Bo Jiang, Ding Wang, Ding Wang, Ding Wang, Xiangyu Chu, Xiangyu Chu, Xiangyu Chu, Longyuan Jia, Longyuan Jia, Longyuan Jia, Shijie Xin, Shijie Xin, Shijie Xin   +23 more
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The treatment choices of abdominal aortic aneurysm patients in China in the era of value-based healthcare

Frontiers in Cardiovascular Medicine, 2022
BackgroundEndovascular aneurysm repair (EVAR) is often seen as the first choice treatment for patients with abdominal aortic aneurysm (AAA), particularly high-risk patients, yet the long-term survival rate and improvement in quality of life are still ...
Liren Duan, Liren Duan, Wei Xin, Shenli Li, Lin Zhao, Shijie Xin, Shijie Xin   +6 more
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Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm

Frontiers in Physiology, 2020
Aim: Smoking is a major risk factor for abdominal aortic aneurysm (AAA). Among the components of smoke, nicotine is known to exert pro-atherosclerotic, prothrombotic, and proangiogenic effects on vascular smooth muscle cells (VSMCs).
Liren Duan, Shenli Li, Lei Wang, Yuchen Jing, Guangxin Li, Yaodong Sun, Weifeng Sun, Yalun Li, Lin Zhao, Shijie Xin   +9 more
doaj   +1 more source

Fluid-structure instability forecasts thoracic aortic aneurysm progression [PDF]

Nat. Biomed. Eng 7, 1614-1626 (2023), 2021
The basic mechanism driving aneurysm growth is unknown. Currently, clinical diagnosis of an aneurysm is mainly informed by retrospective tracking of its size and growth rate. However, aneurysms can rupture before reactive criteria are met or remain stable when they are exceeded.
arxiv   +1 more source

Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the second most prevalent aortic disease following atherosclerosis, representing the ninth‐leading cause of death globally. Open surgery and endovascular procedures are
Haocheng Lu, Wa Du, Lu Ren, Milton H. Hamblin, Richard C. Becker, Y. Eugene Chen, Yanbo Fan   +6 more
doaj   +1 more source