An International Delphi Study on Barriers to On‐Demand Treatment of Hereditary Angioedema Attacks [PDF]
ABSTRACT Background Hereditary angioedema (HAE) is a rare inherited disorder characterized by unpredictable and potentially life‐threatening attacks of swelling. This international Delphi panel aimed to address questions related to on‐demand treatment of HAE attacks. Methods A modified Delphi method was conducted with three rounds of surveys.
Aleena Banerji +20 more
wiley +2 more sources
Acute Urticaria as the Sole Manifestation of Dengue Fever: A Rare Case Report [PDF]
ABSTRACT Urticaria is a very uncommon dermatological manifestation of infection by the dengue virus. It can hinder diagnosis since some of its features overlap with allergic conditions, such as maculopapular and petechial rashes. We present a case of a 32‐year‐old male, resident of a dengue‐endemic area, who presented with an acute onset of generalized
Md Osman Goni +6 more
wiley +2 more sources
An adolescent girl with signs and symptoms of anaphylaxis and negative immunologic workup: a case report. [PDF]
BackgroundThe increasing incidence of allergies and allergic reactions among children and adults has become a major public health concern. The etiology of allergic reactions can often be confirmed based on a detailed history and supportive testing ...
Bauer, Maureen +4 more
core
What proportion of adult allergy referrals to secondary care could be dealt with in primary care by a GP with special interest? [PDF]
Background: The concept of a General Practitioner with Special Interest (GPwSI) was first proposed in the 2000 National Health Service Plan, as a way of providing specialised treatment closer to the patient’s home and reducing hospital waiting times ...
A Bowling +8 more
core +1 more source
Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF [PDF]
The natriuretic peptide (NP) system, which includes atrial natriuretic peptide, B-type natriuretic peptide, and C-type natriuretic peptide, has an important role in cardiovascular homeostasis, promoting a number of physiological effects including ...
Rubattu, Speranza Donatella +1 more
core +2 more sources
Simvastatin: A Risk Factor for Angioedema? [PDF]
Objective. To report a case of simvastatin-induced angioedema in a patient with near nightly episodes of orofacial angioedema. Case Summary. A 75-year-old African American female presented to the emergency department with recurrent face, lip, and tongue ...
Kara, Areeba +2 more
core +2 more sources
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley +1 more source
Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel +12 more
wiley +1 more source
SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children [PDF]
Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs).
Arasi, Stefania +19 more
core +1 more source
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel +4 more
wiley +1 more source

