Results 71 to 80 of about 577,014 (316)
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
Communications Biology, 2021 Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade.
Michael Y. He +11 more
doaj +1 more source
Circulation, 2000 An old specter haunted the 72nd annual sessions of the American Heart Association in Atlanta last November—the awful nothingness of the placebo effect. No one could prove whether it was or it was not there, but its presence cast a pall over some sessions that dealt with one of the most promising therapies to date—angiogenesis.
openaire +2 more sources
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Angiogenesis in Diseases and Therapy
, 2013 Angiogenesis research has become an increasingly attractive field in biomedicine for academic and pharmaceutical scientists because of its broad involvement in various human diseases, including the most common and lethal diseases such as cancer, obesity,
Yihai Cao, Cao, Y
core +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Arteriogenesis versus angiogenesis: similarities and differences
, 2007 Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical ...
Schmitz-Rixen, Thomas +3 more
core +1 more source
Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis [PDF]
, 2010 Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel adipokine, circulating levels of which are raised in inflammatory states.
Randeva, Harpal S. +4 more
core +1 more source
VaccinesBackground/Objectives: Nucleic acid-based anticancer vaccines are becoming a very active field in the fight against cancer. Here, our goal was to generate an oral DNA vaccine targeting the angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
Tom Kalathil Raju +6 more
doaj +1 more source
Cell Reports, 2017 Summary: Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site.
Ward Celus +6 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source