Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity
Biomedicines, 2023 Hidradenitis suppurativa (HS) is a chronic inflammatory disease whose pathogenesis is not fully understood at present. The role of proinflammatory cytokines, several adipokines, retinol-binding protein 4, angiopoietin-2 and other molecules has been ...
José L. Hernández +5 more
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Kidney angiopoietin-like protein 4 regulates fibrotic responses in diabetic kidney disease [PDF]
Frontiers in PharmacologyThe angiopoietin-like (ANGPTL) proteins are now recognized as critical regulators of the harmful changes seen in diabetic kidney disease. Notably, a hyposialylated pro-proteinuric form of ANGPTL4 has been identified as a crucial contributor to fibrosis ...
Swayam Prakash Srivastava +9 more
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On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
Journal of Lipid Research, 2019 Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL.
Oleg Kovrov +4 more
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Serum Angiopoietin‐Like Protein 4 as a Biomarker for Acute Ischemic Stroke Severity and Dynamic Changes [PDF]
Brain and BehaviorBackground Angiopoietin‐like protein 4 (ANGPTL4) is critical for vascular integrity and reducing inflammation in ischemic and hypoxic brain injuries. However, limited studies have evaluated ANGPTL4's role in acute ischemic stroke (AIS) assessment, and ...
Fang Guo +6 more
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Angiopoietin-like protein 3: a novel potential biomarker for nephrotic syndrome in children [PDF]
Frontiers in Pediatrics, 2023 BackgroundAngiopoietin-like 3 (ANGPTL3) is a secretory glycoprotein. It has been demonstrated that ANGPTL3 level was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues.
Fujie Wen +11 more
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Angiopoietin-Like Protein 3 (ANGPTL3) Inhibitors in the Management of Refractory Hypercholesterolemia [PDF]
Clinical Pharmacology: Advances and Applications, 2022 Constantine E Kosmas,1,2 Maria D Bousvarou,3 Andreas Sourlas,3 Evangelia J Papakonstantinou,4 Edilberto Peña Genao,2 Rogers Echavarria Uceta,2 Eliscer Guzman1,2 1Division of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, NY, USA ...
Kosmas CE +6 more
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Role of the angiopoietin-like protein family in the progression of NAFLD [PDF]
HeliyonNon-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease, with a range of conditions including non-alcoholic fatty liver, non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC).
Xin Su +6 more
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Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]
MedicinaBackground and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya +3 more
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Plasma angiopoietin-like protein 4 as a novel biomarker predicting 10-year mortality in a community-based population: a longitudinal cohort study [PDF]
Archives of Medical ScienceIntroduction Angiopoietin-like protein 4 (ANGPTL4) is a hepatokine implicated in fat metabolism regulation. Its genetic inactivation has been associated with improved glucose homeostasis, while elevated plasma ANGPTL4 levels are observed in diabetic and ...
Kang-Chih Fan +9 more
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Heliyon, 2023 High metastatic potential and resistance to immunotherapy lead to poor survival in patients with ovarian cancer. Angiopoietin-like protein 3 is aberrantly expressed and exerts diverse roles in the progression of several cancers.
Yuxian Wu, Yaqun Zheng, Zhijun Jin
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