Results 131 to 140 of about 7,590,894 (205)

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi   +9 more
wiley   +1 more source

Der Effekt von Entzündungsmediatoren auf die Produktion von Angiopoietin-like 4 in parodontalen Fibroblasten unter hypoxischen Bedingungen.

open access: yes, 2019
Einleitung: Parodontale Erkrankungen stellen in der Zahnheilkunde ein für Zahnverlust verantwortliches Problem dar. Es ist bekannt, dass das Zusammenspiel vieler Faktoren für die Entstehung dieser oft schwer therapierbaren Krankheit die Schuld trägt.
Kernstock, Kurt
core  

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao   +7 more
wiley   +1 more source

Global Proteomic Analysis of Sperm and Seminal Plasma From Tropically‐Adapted Rams With Contrasting Parameters of Frozen‐Thawed Semen

open access: yesMolecular Reproduction and Development, Volume 93, Issue 10, October 2026.
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco   +14 more
wiley   +1 more source

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.
Seongwan Kim   +2 more
wiley   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

open access: yesInternational Endodontic Journal, Volume 59, Issue 10, Page 2122-2142, October 2026.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang   +9 more
wiley   +1 more source

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

open access: yesInternational Endodontic Journal, Volume 59, Issue 10, Page 2143-2163, October 2026.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa   +5 more
wiley   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 10, Page 1667-1685, October 2026.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu   +5 more
wiley   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

open access: yesThe FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini   +6 more
wiley   +1 more source

Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence

open access: yesPharmacological Research
Han-Yong Hou   +4 more
doaj   +1 more source

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