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Egyptian Pharmaceutical Journal, 2023
Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
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Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
openaire +1 more source
Angiopoietins and Angiopoietin-Like Proteins in Angiogenesis
Endothelium, 2006Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling.
Tohru, Morisada +4 more
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Angiopoietin-like proteins and postprandial partitioning of fatty acids
Current Opinion in Lipidology, 2021Purpose of review Over the last two decades, evolving discoveries around angiopoietin-like (ANGPTL) proteins, particularly ANGPTL3, ANGPTL4, and ANGPTL8, have generated significant interest in understanding their roles in fatty acid (FA) metabolism.
Nicole M, DiDonna +2 more
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Angiopoietin-like proteins in multiple sclerosis
Journal of Neuroimmunology, 2019Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy.
Rabeah, Al-Temaimi +3 more
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Regulation of triglyceride metabolism by Angiopoietin-like proteins
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012Plasma triglyceride concentrations are determined by the balance between production of the triglyceride-rich lipoproteins VLDL and chylomicrons in liver and intestine, and their lipoprotein lipase-mediated clearance in peripheral tissues. In the last decade, the group of Angiopoietin-like proteins has emerged as important regulators of circulating ...
Mattijssen, F.B.J., Kersten, A.H.
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The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Trends in Cardiovascular Medicine, 2008Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins.
Tai, Hato +2 more
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Regulation of lipid metabolism by angiopoietin-like proteins
Current Opinion in Lipidology, 2016The angiopoietin-like proteins (ANGPTLs) 3, 4 and 8 have emerged as key regulators of plasma lipid metabolism by serving as potent inhibitors of the enzyme lipoprotein lipase (LPL). In this review, we provide an integrated picture of the role of ANGPTL3, ANGPTL4 and ANGPTL8 in lipid metabolism by focusing on their impact on LPL activity and plasma ...
Dijk, Wieneke, Kersten, Sander
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Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE−/− mice [PDF]
Atherosclerosis, 2020 Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in regulating lipid metabolism. Patients with coronary artery disease have markedly higher plasma levels of ANGPTL8 than controls; however, the role of ANGPTL8 in atherosclerosis has not been explored.
Yunxiao Yang, Huahui Yu, Juan Li
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The angiopoietin-like protein 3
Current Opinion in Lipidology, 2013Cumulating evidence are revealing roles of angiopoietin-like proteins (ANGPTLs) in lipid, glucose, and energy metabolism. In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3.Several groups have reported clinical and metabolic characterization of individuals with loss ...
ARCA, Marcello +2 more
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Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency
Current Opinion in Lipidology, 2020Purpose of review Angiopoietin-like protein-3 (ANGPTL3) is emerging as a key player in lipoprotein transport with an expanding role on fatty acid and glucose metabolism. Its deficiency is associated with a favorable metabolic profile.
Arca M., D'Erasmo L., Minicocci I.
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