Results 161 to 170 of about 275,373 (195)

Angiopoietin-like 3: An important protein in regulating lipoprotein levels

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
ANGPTL3 has emerged as a therapeutic target whose inhibition results in profound reductions of plasma lipids, including atherogenic triglyceride-rich lipoproteins and low-density lipoprotein cholesterol. The identification of ANGPTL3 deficiency as a cause of familial combined hypolipidemia in humans hastened the development of anti-ANGPTL3 therapeutic ...
Kendall H, Burks, Debapriya, Basu, Ira J, Goldberg, Nathan O, Stitziel   +3 more
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Response of Angiopoietin-like Proteins 3 and 4 to Hemodialysis

The International Journal of Artificial Organs, 2014
Background/Aim Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL) 3 and 4 have been shown to inactivate LPL. The aim of this study was to investigate the levels of the ANGPTLs in plasma of cHD-patients and to evaluate if cHD may alter ...
Dana, Mahmood, Elena, Makoveichuk, Solveig, Nilsson, Gunilla, Olivecrona, Bernd, Stegmayr   +4 more
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Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis

International Journal of Hematology, 2004
A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Yuichi, Oike, Kunio, Yasunaga, Toshio, Suda   +2 more
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The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis

Biochemical and Biophysical Research Communications, 2012
Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's sign. Treatment with a non-specific immunosuppressive agent or anti-inflammatory corticosteroids is beneficial, although some ...
Aki, Ogata, Motoyoshi, Endo, Jun, Aoi, Otowa, Takahashi, Tsuyoshi, Kadomatsu, Keishi, Miyata, Zhe, Tian, Masatoshi, Jinnin, Satoshi, Fukushima, Hironobu, Ihn, Yuichi, Oike   +10 more
openaire   +2 more sources

Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

Clinica Chimica Acta, 2020
Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease (CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins (ANGPTLs) family, especially ANGPTL3, ANGPTL4 and ANGPTL8, which regulate lipoprotein lipase (LPL) activity, play pivotal roles in triglyceride (TG) metabolism and ...
Jing, Li, Liang, Li, DongMing, Guo, SuYun, Li, YuXin, Zeng, ChuHao, Liu, Ru, Fu, MengQian, Huang, Wei, Xie   +8 more
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Angiopoietin-like proteins: Another player in the metabolic field

Journal of Hepatology, 2006
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor (AGF), a member of the angiopoietin-
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Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
There is evidence that elevated plasma triglycerides (TG) serve as an independent risk factor for coronary heart disease. Plasma TG levels are determined by the balance between the rate of production of chylomicrons and VLDL in intestine and liver, respectively, and their rate of clearance in peripheral tissues.
Lichtenstein, L.L., Kersten, A.H.
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Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation

Metabolism, 2017
Several studies have reported that angiopoietin-like protein 2 (Angptl2) is expressed abundantly in adipocytes and is associated with adipose tissue inflammation. In the present study, we found that osteoblasts and mesenchymal stem cells also expressed Angptl2 at high levels.
Aiko, Takano, Takao, Fukuda, Takanori, Shinjo, Misaki, Iwashita, Etsuko, Matsuzaki, Kensuke, Yamamichi, Masaaki, Takeshita, Terukazu, Sanui, Fusanori, Nishimura   +8 more
openaire   +2 more sources

Regulation of lipid metabolism via angiopoietin-like proteins

Biochemical Society Transactions, 2005
Regulation of mammalian energy metabolism is an intricate process involving numerous hormones, transcription factors and signal transduction cascades. Much of the regulation occurs via secreted factors that relay information from one organ to another.
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Angiopoietin like protein 4 expression is decreased in activated macrophages

Biochemical and Biophysical Research Communications, 2012
Angiopoietin like protein 4 (ANGPTL4) inhibits lipoprotein lipase (LPL) activity. Previous studies have shown that Toll-like Receptor (TLR) activation increases serum levels of ANGPTL4 and expression of ANGPTL4 in liver, heart, muscle, and adipose tissue in mice.
Kenneth R, Feingold, Judy K, Shigenaga, Andrew S, Cross, Arthur, Moser, Carl, Grunfeld   +4 more
openaire   +2 more sources