Results 1 to 10 of about 3,678 (128)

Gene Silencing of ANGPTL3 Induces PCSK9: Exploring the Biological Significance in the Hepatoma Huh7 Cell Line [PDF]

Cells
Background: Angiopoietin-like 3 (ANGPTL3) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are key regulators of lipid homeostasis. We have previously shown that gene silencing of ANGPTL3 significantly induces PCSK9 expression in the human ...
Ilaria Rossi, Ruolan Chen, Enidia Hazizaj, Maria Giovanna Lupo, Giorgia Marodin, Stijn Cos, Alessandra Giannella, Giulio Ceolotto, Nicola Ferri   +8 more
doaj   +2 more sources

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway

Biomolecules, 2022
Background: ANGPTL3 stimulates lipolysis in adipocytes, but the underlying molecular mechanism is yet unknown. The C-terminal fibrinogen-like domain of ANGPTL3 (ANGPTL3-Fld) activates the AKT pathway in endothelial cells.
Luca Polito, Alessia di Costanzo, Simone Bini   +2 more
exaly   +3 more sources

Angiopoietin-like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride-rich lipoproteins in humans. [PDF]

J Intern Med
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Arca M, Björnson E, D'Erasmo L, Costanzo AD, Bini S, Minicocci I, Tramontano D, Covino S, Ciarlo G, Lombardi M, Söderlund S, Matikainen N, Andersson L, Adiels M, Taskinen MR, Packard CJ, Borén J.   +16 more
europepmc   +2 more sources

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management. [PDF]

MedComm (2020)
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Qi S, Chen W, Chen K, Yang S, Wang S, Ni T, Xu D, Mao E, Chen E, Chen Y.   +9 more
europepmc   +2 more sources

Targeting ANGPTL3 and IL-33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis. [PDF]

Adv Sci (Weinh)
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Li Z, Cao Z, Zhou R, Cheng X, Hu X, Xu S, Dou Z, Du L, Ju D.   +8 more
europepmc   +2 more sources

Urinary ANGPTL3: a novel noninvasive biomarker for podocyte injury in pediatric glomerular diseases [PDF]

Journal of Translational Medicine
Background Podocyte injury constitutes the pathological basis of various glomerular diseases; however noninvasive tools for assessing podocyte injury remain limited.
Hengmin Wang, Jiaojiao Liu, Rufeng Dai, Chunyan Wang, Xiaotian Chen, Xin Wang, Jialu Liu, Xiaoshan Tang, Xinli Han, Yihui Zhai, Qian Shen, Hong Xu   +11 more
doaj   +2 more sources

Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5 [PDF]

Journal of Lipid Research
Fenofibrate and other fibrates are peroxisome proliferator–activated receptor alpha agonists that are used to lower plasma triglyceride (TG) levels. Although fibrates are effective in decreasing TG, their ability to reduce adverse cardiovascular events ...
Ye Yang, Sydney Smith, Yan Q. Chen, Hongxia Li, Eugene Y. Zhen, John H. Sloan, Robert W. Siegel, Yuewei Qian, Yi Wen, Hyesoo Jung, Julia L. Scheithauer, Sander Kersten, Stephen G. Young, Robert J. Konrad   +13 more
doaj   +2 more sources

Associations of ANGPTL3/4/8 proteins and complexes with heart failure and heart failure mortality [PDF]

Lipids in Health and Disease
Background Angiopoietin-like 3/4/8 (ANGPTL3/4/8) proteins play critical roles in modulating lipid metabolism through calorically sensitive and tissue-specific regulation of lipoprotein lipase (LPL) activity via formation of ANGPTL3/8 and ANGPTL4/8 ...
Günther Silbernagel, Ann-Cathrin Maas, Hongxia Li, Deven Lemen, Yan Q. Chen, Eugene Y. Zhen, Yi Wen, Marcus E. Kleber, Graciela Delgado, Angela P. Moissl, Winfried März, Alexander Niessner, Hubert Scharnagl, Robert J. Konrad   +13 more
doaj   +2 more sources

SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters [PDF]

Lipids in Health and Disease
Background Angiopoietin-like protein 3 (Angptl3), a factor secreted by the liver, inhibits lipoprotein lipase and other lipases by forming a complex with Angptl4 and 8.
Xiaohong Zhang, Yufei Han, Liwen Zheng, Xiaokui He, Yungang Pu, Lili Wei, Yuhui Wang, Xunde Xian   +7 more
doaj   +2 more sources

The ANGPTL3-integrin α5 axis drives retinal vascular leakage in diabetic retinopathy [PDF]

Journal of Translational Medicine
Background Breakdown of the blood-retinal barrier (BRB) is a key driver of diabetic retinopathy (DR). While Angiopoietin-like protein 3 (ANGPTL3) is a clinical predictor of DR, its causal role and mechanism in retinal vascular pathology are unknown ...
Jing Ke, Yongsong Xu, Yingjun Zhu, Xiaotong Feng, Haodi Cao, Longyan Yang, Dong Zhao   +6 more
doaj   +2 more sources