Results 1 to 10 of about 4,091 (198)

A CPEB2/ANGPTL3 feedback loop promotes the progression of podocyte injury in nephrotic syndrome [PDF]

Scientific Reports
Podocyte injury is the primary pathology responsible for 70–90% of nephrotic syndrome (NS) in children, a condition closely associated with the aberrant expression of Angiopoietin-like-3 (ANGPTL3). The regulatory mechanism by which ANGPTL3 is upregulated
Xin Zheng, Shuibao Chen, Yizhong Chen, Yuling Wu, Fan Lin, Zihua Yu   +5 more
doaj   +3 more sources

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway

Biomolecules, 2022
Background: ANGPTL3 stimulates lipolysis in adipocytes, but the underlying molecular mechanism is yet unknown. The C-terminal fibrinogen-like domain of ANGPTL3 (ANGPTL3-Fld) activates the AKT pathway in endothelial cells.
Simone Bini, Valeria Pecce, Alessia Di Costanzo   +2 more
exaly   +4 more sources

ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase.
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst   +11 more
doaj   +3 more sources

SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters [PDF]

Lipids in Health and Disease
Background Angiopoietin-like protein 3 (Angptl3), a factor secreted by the liver, inhibits lipoprotein lipase and other lipases by forming a complex with Angptl4 and 8.
Xiaohong Zhang, Yufei Han, Liwen Zheng, Xiaokui He, Yungang Pu, Lili Wei, Yuhui Wang, Xunde Xian   +7 more
doaj   +2 more sources

The ANGPTL3-integrin α5 axis drives retinal vascular leakage in diabetic retinopathy [PDF]

Journal of Translational Medicine
Background Breakdown of the blood-retinal barrier (BRB) is a key driver of diabetic retinopathy (DR). While Angiopoietin-like protein 3 (ANGPTL3) is a clinical predictor of DR, its causal role and mechanism in retinal vascular pathology are unknown ...
Jing Ke, Yongsong Xu, Yingjun Zhu, Xiaotong Feng, Haodi Cao, Longyan Yang, Dong Zhao   +6 more
doaj   +2 more sources

Investigation of the relationship between carotid intima-media thickness and angiopoietin-like factor 3 levels in metabolic dysfunction-associated steatotic liver disease [PDF]

Scientific Reports
Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common condition characterized by excessive fat accumulation in the liver and is closely associated with metabolic ...
Elif Kadioglu Yeniyurt, Eda Nur Duran, Seyma Dumur, Iskender Ekinci, Isa Yalcinkaya, Muge Ustuner, Huseyin Emre Carpan, Gulden Anataca, Murat Akarsu, Ummihan Topal, Hafize Uzun, Omur Tabak   +11 more
doaj   +2 more sources

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Journal of Lipid Research, 2022
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting ...
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad   +16 more
doaj   +1 more source

ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome

Lipids in Health and Disease, 2022
Background It is unclear why primary nephrotic syndrome (PNS) patients often have dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipid metabolism.
Fu Zhong, Shurao Liu, Yue Li, Guanyu Li, Ming Liu, Jingzhi Wang, Weijing Cui, Yanhong Suo, Xia Gao   +8 more
doaj   +1 more source

Angiopoietin-like protein 3: a novel potential biomarker for nephrotic syndrome in children

Frontiers in Pediatrics, 2023
BackgroundAngiopoietin-like 3 (ANGPTL3) is a secretory glycoprotein. It has been demonstrated that ANGPTL3 level was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues.
Fujie Wen, Junchao Liu, Rufeng Dai, Sha Hong, Baowei Ji, Jiaojiao Liu, Jun Zhang, Xinli Han, Qianying Lv, Jialu Liu, Qian Shen, Hong Xu   +11 more
doaj   +1 more source

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Journal of Lipid Research, 2021
Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of plasma
Thomas A. Bell, III, Mingxia Liu, Aaron J. Donner, Richard G. Lee, Adam E. Mullick, Rosanne M. Crooke   +5 more
doaj   +1 more source