ANGPTL3 gene variants in subjects with familial combined hyperlipidemia [PDF]
Scientific Reports, 2021 Angiopoietin-like 3 (ANGPTL3) plays an important role in lipid metabolism in humans. Loss-of-function variants in ANGPTL3 cause a monogenic disease named familial combined hypolipidemia.
A. M. Bea +7 more
doaj +2 more sources
ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase.
Jordan M. Kraaijenhof +11 more
doaj +3 more sources
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
Molecular Metabolism, 2017 Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi +9 more
doaj +2 more sources
Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
Metabolites, 2022 Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation.
Anna Stefanska +5 more
doaj +2 more sources
A CPEB2/ANGPTL3 feedback loop promotes the progression of podocyte injury in nephrotic syndrome
Scientific ReportsPodocyte injury is the primary pathology responsible for 70–90% of nephrotic syndrome (NS) in children, a condition closely associated with the aberrant expression of Angiopoietin-like-3 (ANGPTL3). The regulatory mechanism by which ANGPTL3 is upregulated
Xin Zheng +5 more
doaj +2 more sources
ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism [PDF]
Journal of Lipid ResearchAngiopoietin-like protein 3 (ANGPTL3) is a hepatically secreted protein and therapeutic target for reducing plasma triglyceride-rich lipoproteins and low-density lipoprotein (LDL) cholesterol.
Kendall H. Burks +15 more
doaj +2 more sources
HeliyonAngiopoietin-like protein 3 (ANGPTL3) is key in ovarian cancer (OC) cell growth and metastasis, notably by enhancing natural killer cells' capacity for inducing cell toxicity and apoptosis.
Dandan Wu +5 more
doaj +2 more sources
ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition
Journal of Lipid Research, 2021 : Triglyceride (TG) molecules represent the major storage form of fatty acids, and TG metabolism is essential to human health. However, the mechanistic details surrounding TG metabolism are complex and incompletely elucidated.
Yan Q. Chen +6 more
doaj +2 more sources
ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states
Scientific ReportsAngiopoietin-like 3 (ANGPTL3) is a key regulator of lipoprotein metabolism, known for its potent inhibition on intravascular lipoprotein and endothelial lipase activities. Recent studies have shed light on the cellular functions of ANGPTL3.
Taylor Hanta Nagai +6 more
doaj +2 more sources
ANGPTL3 in Podocytes Contributes to the Pathogenesis of Lupus Nephritis by Activating MSR1 in Macrophages [PDF]
Kidney DiseasesIntroduction: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is characterized by persistent immune dysregulation and glomerular injury predominantly driven by macrophage infiltration and type I interferon ...
Qianying Lv +9 more
doaj +2 more sources