Results 11 to 20 of about 4,093 (216)

Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5 [PDF]

Journal of Lipid Research
Fenofibrate and other fibrates are peroxisome proliferator–activated receptor alpha agonists that are used to lower plasma triglyceride (TG) levels. Although fibrates are effective in decreasing TG, their ability to reduce adverse cardiovascular events ...
Ye Yang, Sydney Smith, Yan Q. Chen, Hongxia Li, Eugene Y. Zhen, John H. Sloan, Robert W. Siegel, Yuewei Qian, Yi Wen, Hyesoo Jung, Julia L. Scheithauer, Sander Kersten, Stephen G. Young, Robert J. Konrad   +13 more
doaj   +2 more sources

Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase [PDF]

JCI Insight
Angiopoietin-like 3 (ANGPTL3) is a major regulator of lipoprotein metabolism. ANGPTL3 deficiency results in lower levels of triglycerides, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C), and may protect from cardiovascular disease.
Sydney G. Walker, Yan Q. Chen, Kelli L. Sylvers-Davie, Alex Dou, Eugene Y. Zhen, Yuewei Qian, Yi Wen, Mariam Ehsani, Sydney Smith, Rakshya Thapa, Maxwell J. Mercer, Lucy Langmack, Bharat Raj Bhattarai, Michael Ploug, Robert J. Konrad, Brandon S.J. Davies   +15 more
doaj   +2 more sources

SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters [PDF]

Lipids in Health and Disease
Background Angiopoietin-like protein 3 (Angptl3), a factor secreted by the liver, inhibits lipoprotein lipase and other lipases by forming a complex with Angptl4 and 8.
Xiaohong Zhang, Yufei Han, Liwen Zheng, Xiaokui He, Yungang Pu, Lili Wei, Yuhui Wang, Xunde Xian   +7 more
doaj   +2 more sources

ANGPTL3 in Podocytes Contributes to the Pathogenesis of Lupus Nephritis by Activating MSR1 in Macrophages [PDF]

Kidney Diseases
Introduction: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is characterized by persistent immune dysregulation and glomerular injury predominantly driven by macrophage infiltration and type I interferon ...
Qianying Lv, Na Zhao, Maoxin Fang, Linan Xu, Xinyue Zhou, Yingying Sun, Qi Qi, Min Luo, Hong Xu, Jia Rao   +9 more
doaj   +2 more sources

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3 [PDF]

Circulation, 2018
Alexandra Chadwick, Niklaus H Evitt, Kiran Musunuru   +2 more
exaly   +2 more sources

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

, 2018
Zhi Zheng, Yunzhi Wang, Chen Zou
exaly   +2 more sources

ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase.
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst   +11 more
doaj   +1 more source

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Journal of Lipid Research, 2022
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting ...
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad   +16 more
doaj   +1 more source

ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome

Lipids in Health and Disease, 2022
Background It is unclear why primary nephrotic syndrome (PNS) patients often have dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipid metabolism.
Fu Zhong, Shurao Liu, Yue Li, Guanyu Li, Ming Liu, Jingzhi Wang, Weijing Cui, Yanhong Suo, Xia Gao   +8 more
doaj   +1 more source

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway

Biomolecules, 2022
Background: ANGPTL3 stimulates lipolysis in adipocytes, but the underlying molecular mechanism is yet unknown. The C-terminal fibrinogen-like domain of ANGPTL3 (ANGPTL3-Fld) activates the AKT pathway in endothelial cells.
Simone Bini, Valeria Pecce, Alessia Di Costanzo, Luca Polito, Ameneh Ghadiri, Ilenia Minicocci, Federica Tambaro, Stella Covino, Marcello Arca, Laura D’Erasmo   +9 more
doaj   +1 more source