Results 21 to 30 of about 4,091 (198)
ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states
Scientific ReportsAngiopoietin-like 3 (ANGPTL3) is a key regulator of lipoprotein metabolism, known for its potent inhibition on intravascular lipoprotein and endothelial lipase activities. Recent studies have shed light on the cellular functions of ANGPTL3.
Taylor Hanta Nagai +6 more
doaj +2 more sources
Journal of Lipid ResearchAngiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown.
William G. Hoffmann +12 more
doaj +2 more sources
Structures of Angptl3 and Angptl4 [PDF]
Scientific Reports, 2020 Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma ...
Biterova, Ekaterina +4 more
openaire +6 more sources
Journal of Lipid Research, 2023 After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen +6 more
doaj +1 more source
Targeting apoC-III and ANGPTL3 in the treatment of hypertriglyceridemia [PDF]
Expert Review of Cardiovascular Therapy, 2020 The prevalence of hypertriglyceridemia (HTG) is increasing. Elevated triglyceride (TG) levels are associated with an increased cardiovascular disease (CVD) risk. Moreover, severe HTG results in an elevated risk of pancreatitis, especially in severe HTG with an up to 350-fold increased risk.
N.S. Nurmohamed +2 more
openaire +2 more sources
ANGPTL3 as a Drug Target in Hyperlipidemia and Atherosclerosis
Current Atherosclerosis Reports, 2022 Elevated low-density lipoprotein cholesterol (LDL-C) and triglyceride-rich lipoproteins (TRLs) or remnants are important risk factors for the development of atherosclerotic cardiovascular disease (ASCVD). The ongoing challenge of not being able to achieve recommended LDL-C targets despite maximally tolerated lipid-lowering therapy (LLT) has led to the ...
Farzahna Mohamed +2 more
openaire +2 more sources
<i>ANGPTL3</i> Gene Editing: Promise and Prudence. [PDF]
Eur CardiolLorenzatti AJ.
europepmc +3 more sources
Frontiers in Cardiovascular Medicine, 2021 Elevated triglyceride (TG) and reduced high-density lipoprotein-cholesterol (HDL-C) plasma levels are risk factors for atherosclerosis and cardiovascular disease.
Ren Zhang
doaj +1 more source
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Journal of Lipid Research, 2021 High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie +4 more
doaj +1 more source
Journal of Lipid Research, 2020 Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques ...
Andrew A. Butler +8 more
doaj +1 more source