Results 21 to 30 of about 4,420 (152)

ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome

Lipids in Health and Disease, 2022
Background It is unclear why primary nephrotic syndrome (PNS) patients often have dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipid metabolism.
Fu Zhong, Shurao Liu, Yue Li, Guanyu Li, Ming Liu, Jingzhi Wang, Weijing Cui, Yanhong Suo, Xia Gao   +8 more
doaj   +1 more source

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Journal of Lipid Research, 2022
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting ...
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad   +16 more
doaj   +1 more source

Angiopoietin-like protein 3: a novel potential biomarker for nephrotic syndrome in children

Frontiers in Pediatrics, 2023
BackgroundAngiopoietin-like 3 (ANGPTL3) is a secretory glycoprotein. It has been demonstrated that ANGPTL3 level was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues.
Fujie Wen, Junchao Liu, Rufeng Dai, Sha Hong, Baowei Ji, Jiaojiao Liu, Jun Zhang, Xinli Han, Qianying Lv, Jialu Liu, Qian Shen, Hong Xu   +11 more
doaj   +1 more source

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease [PDF]

, 2017
Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol.
Marylyn D. Ritchie, Lee, I-Te, Alex Lopez, Hayes M. Dansky, Lukas Habegger, Ritchie, Marylyn D, Rotter, Jerome I, O'Dushlaine, Colm, Aris Baras, Van Hout, Cristopher V, H. Lester Kirchner, Dansky, Hayes M, Cristopher V. Van Hout, Dewey, Frederick E, Kraus, William E, William E. Kraus, Børge G. Nordestgaard, Shumel, Brad, Tybjærg-Hansen, Anne, Murphy, Andrew J, Claudia Schurmann, Carey, David J, Shane McCarthy, Damrauer, Scott, Rader, Daniel J, van den Hoek, Anita M, Gromada, Jesper, Frederick E. Dewey, Liang, Kae-Woei, Reid, Jeffrey G, Princen, Hans M G, Richard L. Dunbar, Omri Gottesman, McCarthy, Shane, Mellis, Scott J, Stahl, Neil, I-Te Lee, Overton, John D, O'Dushlaine, Colm T, Shah, Svati H, George D. Yancopoulos, Aeron Small, Daniel Gipe, Tanya M. Teslovich, Viktoria Gusarova, Hans M.G. Princen, Sara Hamon, Leader, Joseph B, Poulabi Banerjee, Murray, Michael F, Nordestgaard, Børge G, William J. Sasiela, Wayne H.H. Sheu, Wulff, Anders Berg, Hamon, Sara, Shuldiner, Alan R, David H. Ledbetter, Alan R. Shuldiner, Brad Shumel, Banerjee, Poulabi, Jerome I. Rotter, Scott J. Mellis, Xiuqing Guo, Shao, Weiping, Colm O’Dushlaine, Bouzelmat, Aurelie, Pordy, Robert, Schurmann, Claudia, Michael F. Murray, Princen, Hans MG, Ingrid B. Borecki, Neil Stahl, Herman, Gary A, Shannon Bruse, Anders Berg Wulff, Daniel J. Rader, Ledbetter, David H, Baras, Aris, Jesper Gromada, Habegger, Lukas, Andrew J. Murphy, Zhang, Rick, Scott Damrauer, Yancopoulos, George D, Kae-Woei Liang, Anne Tybjærg-Hansen, Sasiela, William J, Svati H. Shah, Borecki, Ingrid B, Small, Aeron, Rick Zhang, Jeffrey G. Reid, Gary A. Herman, Joseph B. Leader, David J. Carey, Zhao, An, Sheu, Wayne HH, Chen, Yii-der I, Anita M. van den Hoek, Kirchner, H Lester, Gusarova, Viktoria, Guo, Xiuqing, John D. Overton, Sheu, Wayne H-H, Lopez, Alex, Gipe, Daniel, Weiping Shao, Penn, John, Teslovich, Tanya M, Dunbar, Richard L, Gottesman, Omri, Aurelie Bouzelmat, Robert Pordy, An Zhao, John Penn, Bruse, Shannon, Yii-Der I. Chen   +116 more
core   +3 more sources

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Journal of Lipid Research, 2021
Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of plasma
Thomas A. Bell, III, Mingxia Liu, Aaron J. Donner, Richard G. Lee, Adam E. Mullick, Rosanne M. Crooke   +5 more
doaj   +1 more source

ANGPTL3 as therapeutic target

, 2021
PURPOSE OF REVIEW: Elevated LDL-C and triglycerides are important risk factors for the development of atherosclerotic cardiovascular disease. Although effective therapies for lipid lowering exist, many people do not reach their treatment targets.
Kersten, Sander
core   +1 more source

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

Journal of Lipid Research, 2023
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad   +6 more
doaj   +1 more source

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3 [PDF]

, 2021
BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease (ASCVD) is of fundamental importance given its global health and economic burden.
Michael, Laura F., Glahn, David C., Mahaney, Michael C., Curran, Joanne E., Giles, Corey, Kumar, Satish, Duggirala, Ravindranath, Bellinger, Melissa A., Meikle, Peter J., Duggirala, Ravi, Blackburn, Nicholas B., Leandro, Ana C., Huynh, Kevin, VandeBerg, John L., Göring, Harald H. H., Blangero, John, Peralta, Juan M., Williams-Blangero, Sarah, Mahaney, Michael   +18 more
core   +2 more sources

A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice

Frontiers in Immunology, 2022
IntroductionThe pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism of Angiopoietin-like protein 3 (ANGPTL3) can alleviate proteinuria symptoms by inhibiting ...
Qianqian Ma, Xiaozhi Hu, Fangyu Liu, Zhonglian Cao, Lei Han, Kaicheng Zhou, Yu Bai, Yuting Zhang, Yanyang Nan, Qianying Lv, Jia Rao, Tao Wu, Xue Yang, Haidong He, Dianwen Ju, Dianwen Ju, Hong Xu   +16 more
doaj   +1 more source

ANGPTL3 Deficiency and Risk of Hepatic Steatosis

, 2023
Background: ANGPTL3 (angiopoietin-like 3) is a therapeutic target for reducing plasma levels of triglycerides and low-density lipoprotein cholesterol. A recent trial with vupanorsen, an antisense oligonucleotide targeting hepatic production of ANGPTL3 ...
Arca, Marcello, Zheng, Jie, D'Erasmo, Laura, Pigna, Giovanni, Montali, Anna, Di Costanzo, Alessia, Maranghi, Marianna, Lucisano, Giuseppe, Minicocci, Ilenia, Catalano, Carlo, Kang, Chul Joo, Burks, Kendall H, Fierro, Davide, Ceci, Fabrizio, Fraum, Tyler J, Nicolucci, Antonio, Labbadia, Giancarlo, Bini, Simone, Neufeld, Thomas, Di Martino, Michele, Stitziel, Nathan O, Davidson, Nicholas O   +21 more
core   +1 more source