Results 41 to 50 of about 4,091 (198)

Novel Experimental Agents for the Treatment of Hypercholesterolemia

Journal of Experimental Pharmacology, 2021
Ivan Pećin,1,2 Željko Reiner1,2 1Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia; 2Division of Metabolic Diseases, Department of Internal Medicine, University Hospital Center, Zagreb, CroatiaCorrespondence: Željko ReinerDivision of ...
Pećin I, Reiner Ž
doaj  

Concerns on the Genetic or Therapeutic Antagonism of ANGPTL3

Journal of the American College of Cardiology, 2017
We read with great interest the paper by Stitziel et al. [(1)][1], wherein they found that ANGPTL3 deficiency is associated with protection from coronary artery disease (CAD) and that circulating ANGPTL3 concentrations are higher in subjects presenting with myocardial infarction (MI) than ...
Fei, Luo, Yuan, Guo, Zhenfei, Fang, Xiangping, Li   +3 more
openaire   +2 more sources

High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

International Journal of Hypertension, 2020
Background. Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether
Ming-Chun Chen, Bang-Gee Hsu, Chung-Jen Lee, Ji-Hung Wang   +3 more
doaj   +1 more source

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Journal of Lipid Research, 2015
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased ...
Yan Wang, Viktoria Gusarova, Serena Banfi, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs   +5 more
doaj   +1 more source

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S]

Journal of Lipid Research, 2017
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity.
Jorge F. Haller, Ivory J. Mintah, Lisa M. Shihanian, Panayiotis Stevis, David Buckler, Corey A. Alexa-Braun, Sandra Kleiner, Serena Banfi, Jonathan C. Cohen, Helen H. Hobbs, George D. Yancopoulos, Andrew J. Murphy, Viktoria Gusarova, Jesper Gromada   +13 more
doaj   +1 more source

Characterization of Three Kindred with Familial Combined Hypolipidemia Due to Loss of Function Mutations of ANGPTL3. [PDF]

, 2011
Background—Angiopoietin-like protein 3 (ANGPTL3) affects lipid metabolism by inhibiting the activity of lipoprotein and endothelial lipases. Angptl3 knockout mice have marked hypolipidemia, and heterozygous carriers of ANGPLT3, loss-of-function ...
BERTOLINI, STEFANO, Fancello T, PISCIOTTA, LIVIA, Calandra S, Tarugi P, Calabresi L, Zavaroni I, Ardigò D, Magnolo AL, Adorni MP, Franceschini G, Favari E, Bernini F, Simonelli S, Sallo R   +14 more
core   +2 more sources

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for ...
Rene C. Adam, Ivory J. Mintah, Corey A. Alexa-Braun, Lisa M. Shihanian, Joseph S. Lee, Poulabi Banerjee, Sara C. Hamon, Hye In Kim, Jonathan C. Cohen, Helen H. Hobbs, Cristopher Van Hout, Jesper Gromada, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman, Viktoria Gusarova   +15 more
doaj   +1 more source

Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity

Lipids in Health and Disease, 2021
Background We investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis development and determined whether plasma concentrations of ANGPTL3 and ANGPTL4 are related to the degree of coronary stenosis. Methods A total of 305 consecutive patients with
Ting Sun, Wanlin Zhan, Lijiang Wei, Zuojun Xu, Li Fan, Yang Zhuo, Changqian Wang, Junfeng Zhang   +7 more
doaj   +1 more source

Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL)

, 2023
Tingxue Zhang,1,2 Yilin Hou,1,2 Min Liu,2 Xiaoyu Hou,1,2 Yong Tang,2 Luping Ren,2 Guangyao Song1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General ...
Zhang T, Ren L, Liu M, Hou X, Hou Y, Song G, Tang Y   +6 more
core  

Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis

Life, 2023
Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid and lipoprotein trafficking and metabolism and is positively correlated with cardiovascular disease.
Tzu-Chiang Wu, Bang-Gee Hsu, Chiu-Huang Kuo, Chih-Hsien Wang, Jen-Pi Tsai   +4 more
doaj   +1 more source