Results 41 to 50 of about 4,093 (216)

Atypical angiopoietin-like protein that regulates ANGPTL3 [PDF]

Proceedings of the National Academy of Sciences, 2012
Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3 , a gene located in an intron of DOCK7 , results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG).
Fabiana, Quagliarini, Yan, Wang, Julia, Kozlitina, Nick V, Grishin, Rhonda, Hyde, Eric, Boerwinkle, David M, Valenzuela, Andrew J, Murphy, Jonathan C, Cohen, Helen H, Hobbs   +9 more
openaire   +2 more sources

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

Bioscience Reports, 2014
Homozygosity of loss-of-function mutations in ANGPTL3 (angiopoietin-like protein 3)-gene results in FHBL2 (familial combined hypolipidaemia, OMIM #605019) characterized by the reduction of all major plasma lipoprotein classes, which includes VLDL (very ...
Anna Tikka, Jarkko Soronen, Pirkka‑Pekka Laurila, Jari Metso, Christian Ehnholm, Matti Jauhiainen   +5 more
doaj   +1 more source

Decreases in circulating ANGPTL3 /8 concentrations following retatrutide treatment parallel reductions in serum lipids [PDF]

Diabetes Obes Metab
Yi Wen, Deven Lemen, Yanzhu Lin, Yan Chen, Ajit Regmi, William C. Roell, Melissa K. Thomas, Mark L. Hartman, Tamer Coşkun, Zvonko Miličević, Axel Haupt, Giacomo Ruotolo, Robert J. Konrad   +12 more
openalex   +2 more sources

Structures of Angptl3 and Angptl4

, 2020
Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma ...
Biterova, Ekaterina, Esmaeeli Moghaddam Tabalvandani, Mariam, Alanen, Heli I., Saaranen, Mirva, Ruddock, Lloyd W.   +4 more
openaire   +1 more source

High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

International Journal of Hypertension, 2020
Background. Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether
Ming-Chun Chen, Bang-Gee Hsu, Chung-Jen Lee, Ji-Hung Wang   +3 more
doaj   +1 more source

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease [PDF]

New England Journal of Medicine, 2017
Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. It is not known whether such variants or therapeutic antagonism of ANGPTL3 are associated with a reduced risk of ...
Dewey, Frederick E, Gusarova, Viktoria, Dunbar, Richard L, O'Dushlaine, Colm, Schurmann, Claudia, Gottesman, Omri, McCarthy, Shane, Van Hout, Cristopher V, Bruse, Shannon, Dansky, Hayes M, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H Lester, Habegger, Lukas, Lopez, Alex, Penn, John, Zhao, An, Shao, Weiping, Stahl, Neil, Murphy, Andrew J, Hamon, Sara, Bouzelmat, Aurelie, Zhang, Rick, Shumel, Brad, Pordy, Robert, Gipe, Daniel, Herman, Gary A, Sheu, Wayne HH, Lee, I-Te, Liang, Kae-Woei, Guo, Xiuqing, Rotter, Jerome I, Chen, Yii-Der I, Kraus, William E, Shah, Svati H, Damrauer, Scott, Small, Aeron, Rader, Daniel J, Wulff, Anders Berg, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, van den Hoek, Anita M, Princen, Hans MG, Ledbetter, David H, Carey, David J, Overton, John D, Reid, Jeffrey G, Sasiela, William J, Banerjee, Poulabi, Shuldiner, Alan R, Borecki, Ingrid B, Teslovich, Tanya M, Yancopoulos, George D, Mellis, Scott J, Gromada, Jesper, Baras, Aris   +56 more
openaire   +4 more sources

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for ...
Rene C. Adam, Ivory J. Mintah, Corey A. Alexa-Braun, Lisa M. Shihanian, Joseph S. Lee, Poulabi Banerjee, Sara C. Hamon, Hye In Kim, Jonathan C. Cohen, Helen H. Hobbs, Cristopher Van Hout, Jesper Gromada, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman, Viktoria Gusarova   +15 more
doaj   +1 more source

Gene Silencing of ANGPTL3 Induces PCSK9: Exploring the Biological Significance in the Hepatoma Huh7 Cell Line

Cells
Background: Angiopoietin-like 3 (ANGPTL3) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are key regulators of lipid homeostasis. We have previously shown that gene silencing of ANGPTL3 significantly induces PCSK9 expression in the human ...
Ilaria Rossi, Ruolan Chen, Enidia Hazizaj, Maria Giovanna Lupo, Giorgia Marodin, Stijn Cos, Alessandra Giannella, Giulio Ceolotto, Nicola Ferri   +8 more
doaj   +1 more source

ANGPTL3 Gene Editing: Promise and Prudence [PDF]

European Cardiology Review
Lorenzatti AJ.
openaire   +3 more sources

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source