Results 61 to 70 of about 4,091 (198)

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

Angiopoietin-Like Protein 3 Expression is Down-Regulated in Experimentally Pregnant Toxemic Goats

Journal of Integrative Agriculture, 2012
Pregnancy toxemia is a metabolic disorder of lipid and glucose. Recent investigations have found that angiopoietin-like protein 3 (ANGPTL3) can contribute to disorder of carbohydrate and lipid metabolism.
Xiao-jun CHEN, Xia BAI, Pei MAI, Jie CAI, Zhao-ying LIU, Hui WANG, Hong-bo XIAO, Wei DONG, Shui-lian WANG, Zhi-liang SUN   +9 more
doaj   +1 more source

Olezarsen in Hypertriglyceridemia With High Cardiac Risk: A GRADE‐Assessed Meta‐Analysis of Randomized Trials With Trial Sequential Evidence

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This meta‐analysis of randomized trials evaluates olezarsen for hypertriglyceridemia in patients at high cardiovascular risk. Olezarsen significantly improved triglycerides and other atherogenic lipid parameters with generally acceptable safety, supporting its potential as a promising adjunct therapy while highlighting the need for larger and longer ...
Ahmed Emara, Ameer Awashra, Heba Aboeldahab, Ahmed Farid Gadelmawla, Hamza A. Abdul‐Hafez, Abdullah M. Alharran, Amal A. Alsubaiei, Muneera Jasim AlRumaihi, Sara Ahmed Albuhmaid, Abdalhakim Shubietah   +9 more
wiley   +1 more source

Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss

BMC Nephrology, 2019
Background Angiopoietin-like-3 (Angptl3) knockout is known for its protective effects on podocyte injury and proteinuria in the early stage of adriamycin (ADR) nephropathy.
Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen, Hong Xu   +7 more
doaj   +1 more source

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S]

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen, Ajit Regmi, William C. Roell, Haihong Guo, M. Jane Luo, Ruth E. Gimeno, Ferdinand van't Hooft, Robert J. Konrad   +12 more
doaj   +1 more source

Consolidating Clinical Insights and Uncovering Novel Regulatory Mechanisms of Exosomal MicroRNAs in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease: A Systematic Review and Bioinformatics Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Clinical studies identified 93 obesity‐associated and 24 NAFLD‐associated exosomal miRNAs, with let‐7b and miR‐335‐5p emerging as common nodes. Bioinformatics analysis revealed extensive overlap at the functional level, including 40,410 shared miRNA‐mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals,
Qigui Mo, Amirreza Ghafourian, Masoomeh Hamdi, Arian Alidadipour, Mahdieh Soleimani, Maryam Davoudi, Xiaolei Miao, Reza Afrisham, Molood Bagherieh   +8 more
wiley   +1 more source

Serum ANGPTL2 and ANGPTL3 as potential biomarkers for diagnosis of non-alcoholic fatty liver disease

Environmental Disease, 2020
Purpose: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that has a serious effect on worldwide public health. We sought relationships among ANGPTL2, ANGPTL3, and ANGPTL6 with NAFLD metabolic and biochemical parameters, to assess ...
Yan Ma, Yan Wang, Qiang Zhang, Jia-Nan Lang, Long-Yan Yang, Dong Zhao   +5 more
doaj   +1 more source

A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease

Journal of Nanobiotechnology, 2022
Background Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease mainly on account of hypercholesterolemia and may progress to cirrhosis and hepatocellular carcinoma.
Xiaozhi Hu, Jiajun Fan, Qianqian Ma, Lei Han, Zhonglian Cao, Caili Xu, Jingyun Luan, Guangjun Jing, Yanyang Nan, Tao Wu, Yuting Zhang, Hanqi Wang, Yuanzhen Zhang, Dianwen Ju   +13 more
doaj   +1 more source

Hepatitis C Virus and Type 2 Diabetes: Mechanisms, Clinical Impact, and Post‐DAA Management

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Hepatitis C virus (HCV) infection remains a major global health burden despite advances in direct‐acting antiviral (DAA) therapies. Beyond hepatic complications such as cirrhosis and hepatocellular carcinoma (HCC), HCV has been strongly linked to metabolic disorders, particularly type 2 diabetes mellitus (T2DM).
Shen‐Shong Chang, Ching‐Hsuan Liu, Shu‐Yen Chan, Liang‐Tzung Lin   +3 more
wiley   +1 more source

Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Cell Death and Disease, 2022
Proteinuria, an indication of kidney disease, is caused by the malfunction of podocytes, which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has been documented to have a cell-autonomous involvement in podocytes, and
Qianying Lv, Xinli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai, Jiaojiao Liu, Jialu Liu, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu, Jia Rao, Hong Xu   +12 more
doaj   +1 more source