Results 51 to 60 of about 4,091 (198)
Interdisciplinary Medicine, EarlyView.Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen +5 more
wiley +1 more source
In silico prediction of ANGPTL3-EL interaction
, 2022 Angiopoietin-like protein 3 (ANGPTL3) plays an essential role in lipoprotein metabolism. ANGPTL3 inhibits lipoprotein lipase (LPL), that hydrolyzes triglycerides on VLDL, and endothelial lipase (EL) that hydrolyzes phospholipids on HDL.
L. Palazzolo +7 more
core
Allergy, EarlyView.This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva +7 more
wiley +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Characterization of ANGPTL3 Deficiency and Molecular Mechanisms of ANGPTL3 Deficiency-induced Hypolipidemia [PDF]
, 2018 Johdanto: Väitöstyön tarkoituksena oli tutkia ANGPTL3 puutoksen aiheuttamia muutoksia ihmisessä rasva-aineenvaihdunnan osalta kliinisesti, populaatiotasolla sekä solutasolla.
Tikka, Anna
core
ANGPTL3 is a novel HDL component that regulates HDL function
Journal of Translational MedicineBackground Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and high-density lipoprotein (HDL ...
Longyan Yang +12 more
doaj +1 more source
Journal of Internal Medicine, EarlyView.Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca +16 more
wiley +1 more source
In silico prediction of ANGPTL3-endothelial lipase interaction
, 2022 Angiopoietin-like protein 3 (ANGPTL3) plays an essential role in lipoprotein metabolism. ANGPTL3 inhibits lipoprotein lipase (LPL), that hydrolyzes triglycerides on VLDL, and endothelial lipase (EL) that hydrolyzes phospholipids on HDL.
L. Palazzolo +8 more
core
, 2022 Background The aim of this prospective study was to determine the impact of elevated ANGPTL3 (angiopoietin‐like protein 3) on cardiovascular events (CVEs) following acute coronary syndrome (ACS) in patients with or without obstructive sleep apnea (OSA ...
Yanwen Qin +12 more
core +1 more source
Differential regulation and properties of angiopoietin-like proteins 3 and 4
Journal of Lipid Research, 2005 Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge +6 more
doaj +1 more source