Results 31 to 40 of about 4,093 (216)
Cardioprotective Properties of ANGPTL3 Deficiency
Journal of the American College of Cardiology, 2017 We read with great interest the paper by Stitziel et al. [(1)][1], wherein we were excited to learn that angiopoietin-like 3 (ANGPTL3) may be a novel and valuable therapeutic target for coronary artery disease (CAD) and a biomarker for myocardial infarction (MI).
Yuan, Guo, Fei, Luo, Danyan, Xu
openaire +2 more sources
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Journal of Lipid Research, 2021 High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie +4 more
doaj +1 more source
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
Molecular Metabolism, 2017 Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi +9 more
doaj +1 more source
Heliyon, 2021 We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Yan Q. Chen +5 more
doaj +1 more source
JACC: Basic to Translational Science, 2019 Summary: Hyperlipidemia is a major causal risk factor for atherosclerosis and coronary heart disease (CHD). Angiopoietin-like 3 (ANGPTL3) has emerged as a promising molecular target to reduce CHD risk due to its regulation of all 3 major lipid traits ...
Xiao Wang, PhD +1 more
doaj +1 more source
Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
Metabolites, 2022 Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation.
Anna Stefanska +5 more
doaj +1 more source
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
Frontiers in Endocrinology, 2021 ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues.
María Fernanda Garces +16 more
doaj +1 more source
Novel Experimental Agents for the Treatment of Hypercholesterolemia
Journal of Experimental Pharmacology, 2021 Ivan Pećin,1,2 Željko Reiner1,2 1Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia; 2Division of Metabolic Diseases, Department of Internal Medicine, University Hospital Center, Zagreb, CroatiaCorrespondence: Željko ReinerDivision of ...
Pećin I, Reiner Ž
doaj
Gene knockdown of angiopoietin-like protein 3 reduces the occurrence and development of thoracic aortic aneurysms [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the role of angiopoietin-like protein 3 (ANGPTL3) in the development of thoracic aortic aneurysm (TAA) and its possible mechanism. Methods The TAA patients who underwent open surgical repair in Beijing Anzhen Hospital were selected
YU Hua-hui, JIAO Xiao-lu, YANG Yun-yun, LI Fan, SUN Qiu-ju, YU Yu, LYU Qian-wen, QIN Yan-wen
doaj
ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition
Journal of Lipid Research, 2021 : Triglyceride (TG) molecules represent the major storage form of fatty acids, and TG metabolism is essential to human health. However, the mechanistic details surrounding TG metabolism are complex and incompletely elucidated.
Yan Q. Chen +6 more
doaj +1 more source