Results 31 to 40 of about 4,091 (198)

Cardioprotective Properties of ANGPTL3 Deficiency

Journal of the American College of Cardiology, 2017
We read with great interest the paper by Stitziel et al. [(1)][1], wherein we were excited to learn that angiopoietin-like 3 (ANGPTL3) may be a novel and valuable therapeutic target for coronary artery disease (CAD) and a biomarker for myocardial infarction (MI).
Yuan, Guo, Fei, Luo, Danyan, Xu
openaire   +2 more sources

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3

, 2021
BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease (ASCVD) is of fundamental importance given its global health and economic burden.
Michael, Laura F., Glahn, David C., Mahaney, Michael C., Curran, Joanne E., Giles, Corey, Kumar, Satish, Duggirala, Ravindranath, Bellinger, Melissa A., Meikle, Peter J., Duggirala, Ravi, Blackburn, Nicholas B., Leandro, Ana C., Huynh, Kevin, VandeBerg, John L., Göring, Harald H. H., Blangero, John, Peralta, Juan M., Williams-Blangero, Sarah, Mahaney, Michael   +18 more
core   +2 more sources

Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

Frontiers in Endocrinology, 2021
ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues.
María Fernanda Garces, Haiver Antonio Rodriguez - Navarro, Julieth Daniela Buell - Acosta, Alvaro Javier Burgos - Cardenas, Roberto Franco - Vega, Luis Miguel Maldonado - Acosta, Javier Eslava - Schmalbach, Arturo José Parada - Baños, Andres Castro - Pinzon, Elizabeth Sanchez, Edith Angel - Muller, Ezequiel Lacunza, Justo P. Castaño, Carlos Dieguez, Rubén Nogueiras, Ariel Ivan Ruiz - Parra, Jorge Eduardo Caminos   +16 more
doaj   +1 more source

Angiopoietin-Like 3

JACC: Basic to Translational Science, 2019
Summary: Hyperlipidemia is a major causal risk factor for atherosclerosis and coronary heart disease (CHD). Angiopoietin-like 3 (ANGPTL3) has emerged as a promising molecular target to reduce CHD risk due to its regulation of all 3 major lipid traits ...
Xiao Wang, PhD, Kiran Musunuru, MD, PhD, MPH, ML   +1 more
doaj   +1 more source

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

Heliyon, 2021
We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad   +5 more
doaj   +1 more source

Atypical angiopoietin-like protein that regulates ANGPTL3 [PDF]

Proceedings of the National Academy of Sciences, 2012
Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3 , a gene located in an intron of DOCK7 , results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG). We identified another ANGPTL family member,
Fabiana, Quagliarini, Yan, Wang, Julia, Kozlitina, Nick V, Grishin, Rhonda, Hyde, Eric, Boerwinkle, David M, Valenzuela, Andrew J, Murphy, Jonathan C, Cohen, Helen H, Hobbs   +9 more
openaire   +2 more sources

Familial combined hypolipidemia due to mutations in the ANGPTL3 gene [PDF]

, 2013
The role of ANGPTL3 in lipoprotein metabolism emerged from studies in a mutant mouse strain characterized by severe hypotriglyceridemia and carrying a loss-of-function (LOF) mutation of the ANGPTL3 gene.
AVERNA, Maurizio, Tarugi P., Bertolini S., Calandra s, Calandra S., Tarugi P, Averna M.   +6 more
core   +1 more source

ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins [PDF]

, 2020
Loss-of-function (LOF) mutations in ANGPTL3, an inhibitor of lipoprotein lipase (LPL), cause a drastic reduction of serum lipoproteins and protect against the development of atherosclerotic cardiovascular disease.
Metso, Jari, Arca, Marcello, Dalli, Jesmond, D'Erasmo, Laura, Taskinen, Juuso H., Zhou, You, Käkelä, Reijo, Naridas, P. A. Nidhina, Minicocci, Ilenia, di Costanzo, Alessia, Olkkonen, Vesa M., Partanen, Jennimari, Jauhiainen, Matti, Palmas, Francesco, Haridas, P.A. Nidhina, Ruhanen, Hanna   +15 more
core   +2 more sources

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

, 2017
Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3).
Stitziel, Nathan O;Khera, Amit V;Wang, Xiao;Bierhals, Andrew J;Vourakis, A Christina;Sperry, Alexandra E;Natarajan, Pradeep;Klarin, Derek;Emdin, Connor A;Zekavat, Seyedeh M;Nomura, Akihiro;Erdmann, Jeanette;Schunkert, Heribert;Samani, Nilesh J;Kraus, William E;Shah, Svati H;Yu, Bing;Boerwinkle, Eric;Rader, Daniel J;Gupta, Namrata;Frossard, Philippe M;Rasheed, Asif;Danesh, John;Lander, Eric S;Gabriel, Stacey;Saleheen, Danish;Musunuru, Kiran;Kathiresan, Sekar
core   +2 more sources

Gene knockdown of angiopoietin-like protein 3 reduces the occurrence and development of thoracic aortic aneurysms [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the role of angiopoietin-like protein 3 (ANGPTL3) in the development of thoracic aortic aneurysm (TAA) and its possible mechanism. Methods The TAA patients who underwent open surgical repair in Beijing Anzhen Hospital were selected
YU Hua-hui, JIAO Xiao-lu, YANG Yun-yun, LI Fan, SUN Qiu-ju, YU Yu, LYU Qian-wen, QIN Yan-wen
doaj