Results 31 to 40 of about 4,420 (152)

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi[S]

Journal of Lipid Research, 2020
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques ...
Andrew A. Butler, James L. Graham, Kimber L. Stanhope, So Wong, Sarah King, Andrew A. Bremer, Ronald M. Krauss, James Hamilton, Peter J. Havel   +8 more
doaj   +1 more source

The Potential of ANGPTL8 Antagonism to Simultaneously Reduce Triglyceride and Increase HDL-Cholesterol Plasma Levels

Frontiers in Cardiovascular Medicine, 2021
Elevated triglyceride (TG) and reduced high-density lipoprotein-cholesterol (HDL-C) plasma levels are risk factors for atherosclerosis and cardiovascular disease.
Ren Zhang
doaj   +1 more source

In silico prediction of ANGPTL3-endothelial lipase interaction

, 2022
Angiopoietin-like protein 3 (ANGPTL3) plays an essential role in lipoprotein metabolism. ANGPTL3 inhibits lipoprotein lipase (LPL), that hydrolyzes triglycerides on VLDL, and endothelial lipase (EL) that hydrolyzes phospholipids on HDL.
L. Palazzolo, L. Montavoci, O. Ben Mariem, U. Guerrini, L. Calabresi, A. Ossoli, S. Saporiti, T. Laurenzi, I. Eberini   +8 more
core   +2 more sources

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Journal of Lipid Research, 2021
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S.J. Davies   +4 more
doaj   +1 more source

Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

Frontiers in Endocrinology, 2021
ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues.
María Fernanda Garces, Haiver Antonio Rodriguez - Navarro, Julieth Daniela Buell - Acosta, Alvaro Javier Burgos - Cardenas, Roberto Franco - Vega, Luis Miguel Maldonado - Acosta, Javier Eslava - Schmalbach, Arturo José Parada - Baños, Andres Castro - Pinzon, Elizabeth Sanchez, Edith Angel - Muller, Ezequiel Lacunza, Justo P. Castaño, Carlos Dieguez, Rubén Nogueiras, Ariel Ivan Ruiz - Parra, Jorge Eduardo Caminos   +16 more
doaj   +1 more source

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

Heliyon, 2021
We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad   +5 more
doaj   +1 more source

Novel Experimental Agents for the Treatment of Hypercholesterolemia

Journal of Experimental Pharmacology, 2021
Ivan Pećin,1,2 Željko Reiner1,2 1Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia; 2Division of Metabolic Diseases, Department of Internal Medicine, University Hospital Center, Zagreb, CroatiaCorrespondence: Željko ReinerDivision of ...
Pećin I, Reiner Ž
doaj  

Angiopoietin-Like 3

JACC: Basic to Translational Science, 2019
Summary: Hyperlipidemia is a major causal risk factor for atherosclerosis and coronary heart disease (CHD). Angiopoietin-like 3 (ANGPTL3) has emerged as a promising molecular target to reduce CHD risk due to its regulation of all 3 major lipid traits ...
Xiao Wang, PhD, Kiran Musunuru, MD, PhD, MPH, ML   +1 more
doaj   +1 more source

Familial combined hypolipidemia due to mutations in the ANGPTL3 gene [PDF]

, 2013
The role of ANGPTL3 in lipoprotein metabolism emerged from studies in a mutant mouse strain characterized by severe hypotriglyceridemia and carrying a loss-of-function (LOF) mutation of the ANGPTL3 gene.
AVERNA, Maurizio, Tarugi P., Bertolini S., Calandra s, Calandra S., Tarugi P, Averna M.   +6 more
core   +1 more source

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

, 2017
Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3).
Stitziel, Nathan O;Khera, Amit V;Wang, Xiao;Bierhals, Andrew J;Vourakis, A Christina;Sperry, Alexandra E;Natarajan, Pradeep;Klarin, Derek;Emdin, Connor A;Zekavat, Seyedeh M;Nomura, Akihiro;Erdmann, Jeanette;Schunkert, Heribert;Samani, Nilesh J;Kraus, William E;Shah, Svati H;Yu, Bing;Boerwinkle, Eric;Rader, Daniel J;Gupta, Namrata;Frossard, Philippe M;Rasheed, Asif;Danesh, John;Lander, Eric S;Gabriel, Stacey;Saleheen, Danish;Musunuru, Kiran;Kathiresan, Sekar
core   +3 more sources