Results 71 to 80 of about 4,091 (198)

Hepatic‐Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi‐Omics Analysis of Tumors With Lymphovascular Invasion

Cancer Medicine, Volume 15, Issue 4, April 2026.
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima, Yuichiro Tsukada, Riu Yamashita, Takao Fujisawa, Takeshi Kuwata, Reiko Watanabe, Genichiro Ishii, Nina Gabelia, Hartmut Juhl, Yoshikatsu Koga, Takayuki Yoshino, Masaaki Ito, Hitoshi Masuda   +12 more
wiley   +1 more source

Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art

Genetic Epidemiology, Volume 50, Issue 3, April 2026.
ABSTRACT In the last decade, genome‐wide association studies (GWAS) have identified tens of thousands of common variants associated with a wide array of complex traits and diseases. Integration of GWAS with molecular data has informed the development of statistical tools for causal gene discovery.
Karina Patasova, Bahar Sedaghati‐Khayat, Rachel Knevel, Heather J. Cordell, Arthur G. Pratt   +4 more
wiley   +1 more source

Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice

Cell & Bioscience, 2023
Background Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene editing offers hope for a ...
Yuanbojiao Zuo, Chen Zhang, Yuan Zhou, Haiwen Li, Weidong Xiao, Roland W. Herzog, Jie Xu, Jifeng Zhang, Y. Eugene Chen, Renzhi Han   +9 more
doaj   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis

Aging Cell, Volume 25, Issue 3, March 2026.
The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li, Tongtong Bao, Lumin Gao, Xutong Tian, Junyu Xue, Caike Jin, Shujin Wang, Xin Wu   +7 more
wiley   +1 more source

The High Price of Interrupted Follow‐Up: Catastrophic Progression of Homozygous Familial Hypercholesterolemia—A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Familial hypercholesterolemia (FH) is the most common monogenic lipid disorder, primarily resulting from mutations in LDLR, APOB, and PCSK9 genes. These mutations cause persistently high levels of low‐density lipoprotein cholesterol (LDL‐C), predisposing affected individuals to premature atherosclerotic cardiovascular disease (ASCVD ...
Parham Dastjerdi, Mahdieh Aghababaei, Reza Nikfar, Maryam Aghakouchakzadeh, Reza Mohseni‐Badalabadi, Kaveh Hosseini   +5 more
wiley   +1 more source

Regulation of the angiopoietin-like protein 3 gene by LXR

Journal of Lipid Research, 2003
Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angpt1111111175), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid ...
Rebecca Kaplan, Theresa Zhang, Melba Hernandez, Frank Xiaodong Gan, Samuel D. Wright, M.Gerard Waters, Tian-Quan Cai   +6 more
doaj   +1 more source

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine MASH Model

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 2, February 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction‐associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non‐invasive biomarkers for tracking disease progression.
Szu‐Jen Wang, Yung‐Ho Wang, Jee‐Fu Huang, En‐Sheng Lin, Wei‐Shiun Chen, Chia‐Yang Li, Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu, Shu‐Chi Wang   +9 more
wiley   +1 more source

Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism

BioMed Research International, 2019
Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Longyan Yang, Ruili Yin, Zongwei Wang, Xiaobo Wang, Yuanyuan Zhang, Dong Zhao   +5 more
openaire   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, Volume 26, Issue 2-3, Page 33-80, February 2026.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source