Results 81 to 90 of about 4,091 (198)

DataSheet_1_A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice.docx

, 2022
IntroductionThe pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism of Angiopoietin-like protein 3 (ANGPTL3) can alleviate proteinuria symptoms by inhibiting ...
Qianying Lv (12493545), Yuting Zhang (337082), Xiaozhi Hu (3849973), Xue Yang (144876), Dianwen Ju (447665), Tao Wu (16763), Yanyang Nan (5590946), Qianqian Ma (1829734), Lei Han (150108), Hong Xu (71477), Fangyu Liu (92423), Yu Bai (258833), Haidong He (12978554), Kaicheng Zhou (14213603), Zhonglian Cao (2581270), Jia Rao (2266615)   +15 more
core   +1 more source

Evaluation of Pathogenic Variants Associated With Monogenic Disorders of Dyslipidemia in Patients With Well Characterised MASLD

Liver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background and Aims Dyslipidemia is common in patients with MASLD, but the frequency and significance of inherited disorders of dyslipidemia are unclear. We investigated the prevalence and significance of pathogenic variants associated with selected monogenic disorders of dyslipidemia in 3358 patients with well‐characterised MASLD. Approach We
Tae‐Hwi Schwantes‐An, Marco A. Abreu, Brent A. Neuschwander‐Tetri, Jian Wang, Xiuqing Guo, Jingyi Tan, Robert A. Hegele, Nicholas O. Davidson, Luca Lotta, Niek Verweij, Katherine P. Yates, Jerome I. Rotter, Naga Chalasani   +12 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases

Lipids in Health and Disease, 2018
Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (
Xin Su, Dao-quan Peng
doaj   +1 more source

ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase

Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by the angiopoietin-like proteins (ANGPTL3, ANGPTL4, ANGPTL8), which control the ...
Larsen, Sanne W.R., Kumari, Anni, Davies, Brandon S.J., Qian, Yuewei, Remaley, Alan T., Konrad, Robert J., Ploug, Michael, Young, Stephen G., Bondesen, Signe, Jørgensen, Thomas J.D., Tian, Hao D., Walker, Sydney G.   +11 more
core   +2 more sources

Post-GWAS methodologies for localisation of functional non-coding variants:ANGPTL3 [PDF]

, 2015
Genome-wide association studies have confirmed the involvement of non-coding angiopoietin-like 3 (ANGPTL3) gene variants with coronary artery disease, levels of low-density lipoprotein cholesterol (LDL-C), triglycerides and ANGPTL3 mRNA transcript ...
Talmud, PJ, Smith, AJP, Drenos, Fotios, Giambartolomei, Claudia, Palmen, J, Humphries, SE, Plagnol, Vincent, Plagnol, V, Smith, Andrew J. P., Howard, P, Drenos, F, Giambartolomei, C, Talmud, Philippa J., Humphries, Steve E., Smith, Andrew J P, Oldoni, F, Howard, Philip, Oldoni, Federico, Palmen, Jutta, Smith, AJ, Smith, Andrew J.P.   +20 more
core   +1 more source

Evinacumab — an ANGPTL3 inhibitor; a new drug in the treatment of lipid disorders. Review on the literature and clinical studies

, 2021
Angiopoietin-like proteins (ANGPTL) are a family of several proteins, of which ANGPTL3, 4 and 8 are involved in lipid metabolism. These proteins, discovered relatively recently, regulate the availability of triglycerides for the heart, skeletal muscles ...
Filipiak, Krzysztof J.; 1st Chair and Department of Cardiology, Medical University of Warsaw, 21st Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland, Surma, Stanisław; Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland, Romańczyk, Monika; Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland   +2 more
core   +1 more source

ANGPTL3: A Breakthrough Target in Treatment for Dyslipidemia and Atherosclerosis

Journal of Atherosclerosis and Thrombosis
Dyslipidemia is a major risk factor for atherosclerosis and subsequent cardiovascular disease (CVD). Despite conventional treatment with statins, ezetimibe, or PCSK9 inhibitors, there are cases of familial hypercholesterolemia (FH) in which LDL-C levels cannot be sufficiently lowered to the target level, resulting in failure to prevent CVD.
Fukami, Hirotaka, Oike, Yuichi
openaire   +2 more sources

ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization

ANGPTL3 (angiopoietin-like protein 3) is a circulating protein with a key role in maintaining lipoprotein homeostasis. A monoclonal antibody against ANGPTL3 is an approved and well-tolerated treatment to reduce lipoproteins in familial ...
Bergh, Per-Olof,, Ciociola, Ester, Maurotti, Samantha, Jamialahmadi, Oveis,, Petta, Salvatore, Jamialahmadi, Oveis, Tripodo, Claudio, Mirarchi, Angela, Borén, Jan,, Boren, Jan, Bertolazzi, Giorgio, Ciociola, Ester,, Spagnuolo, Rocco, Mancina, Rosellina Margherita,, Romeo, Stefano,, Pennisi, Grazia, Bergh, Per-Olof, Mancina, Rosellina M., Romeo, Stefano, Scionti, Francesca   +19 more
core   +1 more source

Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary

Lipids in Health and Disease
Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types of cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form of gynecological malignancy.
Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah, Anne Gangloff   +10 more
doaj   +1 more source