Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism
BioMed Research International, 2019 Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Longyan Yang +5 more
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Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art
Genetic Epidemiology, Volume 50, Issue 3, April 2026.ABSTRACT In the last decade, genome‐wide association studies (GWAS) have identified tens of thousands of common variants associated with a wide array of complex traits and diseases. Integration of GWAS with molecular data has informed the development of statistical tools for causal gene discovery.
Karina Patasova +4 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan +3 more
wiley +1 more source
Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis
Aging Cell, Volume 25, Issue 3, March 2026.The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li +7 more
wiley +1 more source
Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study [PDF]
, 2021 Maria Cristina Foss‐Freitas +6 more
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Monoclonal Antibodies in the Management of Familial Hypercholesterolemia: Focus on PCSK9 and ANGPTL3 Inhibitors [PDF]
, 2021 Angela Pirillo +2 more
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ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states
Scientific ReportsAngiopoietin-like 3 (ANGPTL3) is a key regulator of lipoprotein metabolism, known for its potent inhibition on intravascular lipoprotein and endothelial lipase activities. Recent studies have shed light on the cellular functions of ANGPTL3.
Taylor Hanta Nagai +6 more
doaj +1 more source
New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases
Lipids in Health and Disease, 2018 Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (
Xin Su, Dao-quan Peng
doaj +1 more source
Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study [PDF]
, 2016 Hye Soo Chung +11 more
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The iPSC Awakens ANGPTL3 in Tangier Disease [PDF]
EBioMedicine, 2017 Man K.S. Lee, Andrew J. Murphy
openaire +3 more sources