Results 81 to 90 of about 4,420 (152)

Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase

JCI Insight
Angiopoietin-like 3 (ANGPTL3) is a major regulator of lipoprotein metabolism. ANGPTL3 deficiency results in lower levels of triglycerides, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C), and may protect from cardiovascular disease.
Sydney G. Walker, Yan Q. Chen, Kelli L. Sylvers-Davie, Alex Dou, Eugene Y. Zhen, Yuewei Qian, Yi Wen, Mariam Ehsani, Sydney Smith, Rakshya Thapa, Maxwell J. Mercer, Lucy Langmack, Bharat Raj Bhattarai, Michael Ploug, Robert J. Konrad, Brandon S.J. Davies   +15 more
doaj   +1 more source

ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase

Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by the angiopoietin-like proteins (ANGPTL3, ANGPTL4, ANGPTL8), which control the ...
Larsen, Sanne W.R., Kumari, Anni, Davies, Brandon S.J., Qian, Yuewei, Remaley, Alan T., Konrad, Robert J., Ploug, Michael, Young, Stephen G., Bondesen, Signe, Jørgensen, Thomas J.D., Tian, Hao D., Walker, Sydney G.   +11 more
core   +2 more sources

Ewinakumab — inhibitor ANGPTL3 — nowy lek w terapii zaburzeń lipidowych. Przegląd literatury i badań klinicznych [PDF]

, 2021
Białka podobne do angiopoetyny (ANGPTL) tworzą rodzinę kilku białek, z których ANGPTL3, 4 i 8 są zaangażowane w metabolizm lipidów. Białka te, odkryte stosunkowo niedawno, regulują dostępność triglicerydów dla serca, mięśni szkieletowych oraz białej i ...
Surma, Stanisław; Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Medyków 18, 40-752 Katowice, Poland, Filipiak, Krzysztof J.; I Katedra i Klinika Kardiologii, Warszawski Uniwersytet Medyczny, Banacha 1a, pawilon D, 02-097 Warszawa, Poland, Romańczyk, Monika; Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Medyków 18, 40-752 Katowice, Poland   +2 more
core  

From Disease Silos to Integrated Cardiometabolic Care: Diabetes, Vascular Disease, and Heart Failure

Journal of Diabetes, Volume 18, Issue 9, September 2026.
Zachary T. Bloomgarden, Yehuda Handelsman   +1 more
wiley   +1 more source

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases

Lipids in Health and Disease, 2018
Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (
Xin Su, Dao-quan Peng
doaj   +1 more source

Post-GWAS methodologies for localisation of functional non-coding variants:ANGPTL3 [PDF]

, 2015
Genome-wide association studies have confirmed the involvement of non-coding angiopoietin-like 3 (ANGPTL3) gene variants with coronary artery disease, levels of low-density lipoprotein cholesterol (LDL-C), triglycerides and ANGPTL3 mRNA transcript ...
Talmud, PJ, Smith, AJP, Drenos, Fotios, Giambartolomei, Claudia, Palmen, J, Humphries, SE, Plagnol, Vincent, Plagnol, V, Smith, Andrew J. P., Howard, P, Drenos, F, Giambartolomei, C, Talmud, Philippa J., Humphries, Steve E., Smith, Andrew J P, Oldoni, F, Howard, Philip, Oldoni, Federico, Palmen, Jutta, Smith, AJ, Smith, Andrew J.P.   +20 more
core   +2 more sources

Investigation of ANGPTL3 expression, exon sequence and promotor methylation between Ningxiang and Changbai pigs [PDF]

, 2013
Background: Angiopoietin-like protein 3 (ANGPTL3), a member of angiopoietin-like proteins, has been demonstrated to affect lipid metabolism by inhibiting the activity of lipoprotein lipase (LPL).
Liu, ZY, Kuang, GW, Zhang, DS, Chen, XJ, Pan, RT, Sun, ZL   +5 more
core   +1 more source

ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization

ANGPTL3 (angiopoietin-like protein 3) is a circulating protein with a key role in maintaining lipoprotein homeostasis. A monoclonal antibody against ANGPTL3 is an approved and well-tolerated treatment to reduce lipoproteins in familial ...
Bergh, Per-Olof,, Ciociola, Ester, Maurotti, Samantha, Jamialahmadi, Oveis,, Petta, Salvatore, Jamialahmadi, Oveis, Tripodo, Claudio, Mirarchi, Angela, Borén, Jan,, Boren, Jan, Bertolazzi, Giorgio, Ciociola, Ester,, Spagnuolo, Rocco, Mancina, Rosellina Margherita,, Romeo, Stefano,, Pennisi, Grazia, Bergh, Per-Olof, Mancina, Rosellina M., Romeo, Stefano, Scionti, Francesca   +19 more
core   +1 more source

Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary

Lipids in Health and Disease
Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types of cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form of gynecological malignancy.
Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah, Anne Gangloff   +10 more
doaj   +1 more source

Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits

Journal of Lipid Research
Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown.
William G. Hoffmann, Yan Q. Chen, Charles S. Schwartz, Jacob L. Barber, Prasun K. Dev, Riley J. Reasons, Juan S. Miranda Maravi, Bridget Armstrong, Robert E. Gerszten, Günther Silbernagel, Robert J. Konrad, Claude Bouchard, Mark A. Sarzynski   +12 more
doaj   +1 more source