Results 91 to 100 of about 4,420 (152)

ANGPTL3 facilitates lipolysis through insulin-resistance development in 3T3-L1 cells.

, 2020
Detection of loss-of-function (LOF) mutations in ANGPTL3 gene in humans revealed the existence of a new lipid phenotype, called familial combined hypolipidemia (FHBL2) and characterized by markedly reduced levels of all lipoproteins.
L. Polito, A. Ghadiri, M. Arca
core  

Effect of ANGPTL3 inhibition with solbinsiran in preclinical and early human studies

Background The residual cardiovascular risk associated with hypertriglyceridemia and remnant particles supports efforts to develop effective novel therapeutic approaches. Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases,
Dudek, Henryk, Saxena, Utsav, Zhen, Eugene Y, Shen, Xi, Lim, Shufen, Michael, Laura F, Turanov, Anton, Ma, Xiaosu, Ray, Kausik K, Linnebjerg, Helle, Ruotolo, Giacomo, Nicholls, Stephen J, Abrams, Marc   +12 more
core   +1 more source

Association of circulating ANGPTL3 level with all-cause and cardiovascular mortality. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Yan S, Zhou B.
europepmc   +1 more source

Permanent Lipid Lowering with CRISPR-Based Interventions: Redefining Laboratory Medicine in the Era of Gene Editing. [PDF]

Clin Chem
Zubiran R, Remaley AT.
europepmc   +1 more source

Associations of Circulating ANGPTL3, C-Terminal Domain-Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality.

BACKGROUND: ANGPTL3/4/8 (angiopoietin-like proteins 3, 4, and 8) are important regulators of LPL (lipoprotein lipase). ANGPTL8 forms complexes with ANGPTL3 and ANGPTL4.
Silbernagel, Günther;Chen, Yan Q;Li, Hongxia;Lemen, Deven;Wen, Yi;Zhen, Eugene Y;Rief, Martin;Kleber, Marcus E;Delgado, Graciela E;Sarzynski, Mark A;Qian, Yue-Wei;Schmidt, Boerge;Erbel, Raimund;Trampisch, Ulrike S;Moissl, Angela P;Rudolf, Henrik;Schunkert, Heribert;Stang, Andreas;März, Winfried;Trampisch, Hans J;Scharnagl, Hubert;Konrad, Robert J
core   +1 more source

Cas12a chRDNA-mediated <i>in vivo</i> genome editing for high specificity functional gene disruption. [PDF]

Mol Ther Nucleic Acids
Losa M, Rajmane P, Stanaway M, Coons M, Munoz A, Garish V, Tan B, Thompson M, Gonzalez R, Churchward G, Owen ALG, Taylor J, An Z, Donohoue PD, Gradia S, Rahdar M, Kanner SB.   +16 more
europepmc   +1 more source

Novel triglyceride-lowering therapies to reduce the risk of acute pancreatitis in hypertriglyceridaemia: a protocol for systematic review and meta-analysis. [PDF]

BMJ Open
Wu Y, Liu S, Luo W, Rao J, He W, Windsor J, Sutton R, Mukherjee R, Shi N, Huang W.   +9 more
europepmc   +1 more source

Anti-ANGPTL3 antibody and IL-22 fusion protein mitigate nephrotic syndrome via mitochondrial protection, anti-apoptosis, and autophagy suppression. [PDF]

Antib Ther
Ma Q, Shao L, Jing G, Liu F, Zhou K, Wen F, He H, Ju D, Xu H.   +8 more
europepmc   +1 more source

SLIT2 and ANGPTL3 as putative mediators linking obesity to atrial fibrillation: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Wu Y, Peng Y, Zhang Q, Xu W, Li Q, Chen X, Lv Z.   +6 more
europepmc   +1 more source

Gene Therapy for Lipid Management: Dawn of a New Era. [PDF]

Cureus
Manoria PC.
europepmc   +1 more source