Results 101 to 110 of about 4,091 (198)

ANGPTL3/8: one target, multiple lipid disorders

Trends in Molecular Medicine
The angiopoietin-like protein (ANGPTL)3/8 complex regulates triglyceride partitioning, and its selective blockade lowers triglycerides while raising HDL-cholesterol (HDL-C). Clinical and genetic evidence support ANGPTL3/8 antagonism as a precision therapy for mixed dyslipidemia, monogenic hypertriglyceridemia (CREBH or APOA5 deficiency), and diabetic ...
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Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

The Journal of biological chemistry, 2004
Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil domain-containing fragment-(17-207) and not the C-terminal fibrinogen-like domain ...
Mitsuru, Ono, Tetsuya, Shimizugawa, Mitsuru, Shimamura, Kenichi, Yoshida, Chisa, Noji-Sakikawa, Yosuke, Ando, Ryuta, Koishi, Hidehiko, Furukawa   +7 more
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ANGPTL3

Journal of the American College of Cardiology, 2017
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Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Therapeutics and Clinical Risk Management, 2018
Yu-Shan Fu,1,* Ji-Hung Wang,1,2,* Chung-Jen Lee,3 Bang-Gee Hsu1,4 1School of Medicine, Tzu Chi University, Hualien, 2Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, 3Department of Nursing, Tzu Chi University of Science and Technology,
Fu YS, Wang JH, Lee CJ, Hsu BG
doaj  

Effect of ANGPTL3 inhibition with solbinsiran in preclinical and early human studies

Background The residual cardiovascular risk associated with hypertriglyceridemia and remnant particles supports efforts to develop effective novel therapeutic approaches. Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases,
Dudek, Henryk, Saxena, Utsav, Zhen, Eugene Y, Shen, Xi, Lim, Shufen, Michael, Laura F, Turanov, Anton, Ma, Xiaosu, Ray, Kausik K, Linnebjerg, Helle, Ruotolo, Giacomo, Nicholls, Stephen J, Abrams, Marc   +12 more
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Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5. [PDF]

J Lipid Res
Yang Y, Smith S, Chen YQ, Li H, Zhen EY, Sloan JH, Siegel RW, Qian Y, Wen Y, Jung H, Scheithauer JL, Kersten S, Young SG, Konrad RJ.   +13 more
europepmc   +1 more source

ANGPTL3: a therapeutic target for atherosclerosis [PDF]

Nature Reviews Cardiology, 2017
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RNA-Targeted Therapeutics for Lipid Metabolic Disorders: From Bench to Bedside. [PDF]

Research (Wash D C)
Ali I, Qiu J, Cheang WS, Wang G, Xu S.
europepmc   +1 more source

CRISPR gene editing of angiopoietin-like 3: toward one-time precision therapy for dyslipidaemia. [PDF]

Signal Transduct Target Ther
Mondal A, Misra A.
europepmc   +1 more source

Effects of ANGPTL3 Deficiency on the Regulation of Hepatic Lipoprotein Production and Lipid Metabolism

Cardiovascular disease is the leading cause of death worldwide. A major treatment goal is to lower plasma lipids, especially low-density lipoprotein cholesterol (LDL), the cardinal risk factor for coronary artery disease (CAD).
Burks, Kendall Helene
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