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Angiopoietin-like proteins: a comprehensive look [PDF]

Frontiers in Endocrinology, 2014
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8.
Gaetano eSantulli
doaj   +8 more sources

Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer [PDF]

Cells, 2021
Secreted angiopoietin/angiopoietin-like (ANGPT/ANGPTL) proteins are involved in many biological processes. However, the role of these proteins in human breast cancers (BCs) remains largely unclear. Here, we conducted integrated omics analyses to evaluate
Hui Yang, Melody Zhang, Xuan-Yu Mao, Hang Chang, Jesus Perez-Losada, Jian-Hua Mao   +5 more
doaj   +6 more sources

Angiopoietin-like proteins inhibitors: New horizons in the treatment of atherogenic dyslipidemia and familial hypercholesterolemia [PDF]

Cardiology Journal, 2023
Angiopoietin-like proteins (ANGPTL) are involved in the regulation of numerous physiological and biochemical processes. ANGPTL3, 4 and 8, which are involved in the regulation of lipoprotein metabolism, are particularly important.
Stanisław Surma, Monika Romańczyk, Krzysztof J. Filipiak   +2 more
doaj   +6 more sources

An Integrated Computational Analysis of High-Risk SNPs in Angiopoietin-like Proteins (ANGPTL3 and ANGPTL8) Reveals Perturbed Protein Dynamics Associated with Cancer [PDF]

Molecules, 2023
Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1–8) which play a pivotal role in the regulation of various pathophysiological processes.
Sajid Iqbal, Farida Begum, Dorothy Wavinya Nyamai, Nasir Jalal, Peter Shaw   +4 more
doaj   +4 more sources

Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins [PDF]

Scientific Reports
High levels of HDL-C are correlated with a decreased risk of cardiovascular disease. HDL-C levels are modulated in part by the secreted phospholipase, endothelial lipase (EL), which hydrolyzes the phospholipids of HDL and decreases circulating HDL-C ...
Kelli L. Sylvers-Davie, Kaleb C. Bierstedt, Michael J. Schnieders, Brandon S. J. Davies   +3 more
doaj   +3 more sources

Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy [PDF]

Metabolites
Angiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local ...
Xinling Zhang, Dongang Liu, Yuting Qiu, Ruiyao Hu, Shiyu Chen, Yue Xu, Chenyan Qian, Lailing Du, Jinghua Yuan, Xiaoping Li   +9 more
doaj   +3 more sources

Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy [PDF]

Biomedicines
Angiopoietins are crucial growth factors for maintaining a healthy, functional endothelium. Patients with type 2 diabetes (T2D) exhibit significant levels of angiogenic markers, particularly Angiopoietin-2, which compromises endothelial integrity and is ...
Eman Alshawaf, Mohamed Abu-Farha, Anwar Mohammad, Sriraman Devarajan, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Hawra Al-Matrouk, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker   +10 more
doaj   +2 more sources

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea [PDF]

Frontiers in Endocrinology, 2018
Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health ...
Abdulmohsen Al-Terki, Mohamed Abu-Farha, Irina AlKhairi, Preethi T. Cherian, Devarajan Sriraman, Ambika Shyamsundar, Shamsha Ali, Fahd Almulla, Jaakko Tuomilehto, Jehad A. Abubaker   +9 more
doaj   +2 more sources

Circulating angiopoietin-like proteins in metabolic-associated fatty liver disease: a systematic review and meta-analysis [PDF]

Lipids in Health and Disease, 2021
Background Angiopoietin-like proteins (ANGPTLs) are closely related to insulin resistance and lipid metabolism, and may be a key in metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) (newly named metabolic-associated fatty liver disease (MAFLD)
Yani Ke, Shan Liu, Zheyuan Zhang, Jie Hu
doaj   +2 more sources

Circulating Angiopoietin-like proteins in Strongyloides Stercoralis infection and reversal following treatment. [PDF]

PLoS Neglected Tropical Diseases
Strongyloides stercoralis (Ss) is a parasitic infection affecting 50-100 million people globally, with significant immune and metabolic consequences, particularly in immunocompromised individuals.
Anuradha Rajamanickam, Saravanan Munisankar, Subash Babu   +2 more
doaj   +2 more sources