Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer [PDF]
International Journal of Molecular Sciences, 2018 Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last decade, emerging evidences supported the autocrine and paracrine activity of the members of the Angiopoietin-like (ANGPTL) protein family in angiogenesis, inflammation and in the regulation of ...
Carmine Carbone +2 more
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Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling [PDF]
eLife, 2015 Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin +18 more
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Angiopoietin-like Proteins in Colorectal Cancer-A Literature Review. [PDF]
Int J Mol Sci, 2021 Colorectal cancer (CRC) is one of the most common types of malignancy, with an annual incidence of about 10% of the total number of new cases. Despite well-developed screening tests, mortality from this type of cancer remains unchanged. Therefore, it is important to search for more accurate markers that are useful in the detection of colorectal cancer (
Zajkowska M, Mroczko B.
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Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders [PDF]
Expert Opinion on Therapeutic Targets, 2020 Introduction: Angiopoietin-like (ANGPTL) proteins belong to a family of eight secreted factors that are structurally related to proteins that modulate angiogenesis; these are commonly known as angiopoietins.
Marco Bruno Morelli, Gaetano Santulli
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Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins [PDF]
JCI InsightFuel substrate switching between carbohydrates and fat is essential for maintaining metabolic homeostasis. During aerobic exercise, the predominant energy source gradually shifts from carbohydrates to fat.
Xiaomin Liu +12 more
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Angiopoietin-Like Proteins 2 and 3 in Children and Adolescents with Obesity and Their Relationship with Hypertension and Metabolic Syndrome [PDF]
International Journal of Hypertension, 2021 Background. Angiopoietin-like protein 2 (ANGPTL2) is one of the adipocyte-derived inflammatory factors which connects obesity to insulin resistance. ANGPTL3 has a direct role in regulation of lipid metabolism.
Zahra Arab Sadeghabadi +6 more
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Pathophysiology, 2022 Biomarker identification is imperative for invasive breast carcinoma, which is more aggressive and associated with higher mortality and worse prognosis in younger patients (50 years).
Zaleha Kamaludin +4 more
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Regulation of lipid metabolism via angiopoietin-like proteins
Biochemical Society Transactions, 2005 Regulation of mammalian energy metabolism is an intricate process involving numerous hormones, transcription factors and signal transduction cascades. Much of the regulation occurs via secreted factors that relay information from one organ to another.
Kersten, A.H.
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Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5 [PDF]
Journal of Lipid ResearchFenofibrate and other fibrates are peroxisome proliferator–activated receptor alpha agonists that are used to lower plasma triglyceride (TG) levels. Although fibrates are effective in decreasing TG, their ability to reduce adverse cardiovascular events ...
Ye Yang +13 more
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Angiopoietin-Like Proteins and Lipid Metabolism
, 2009 Lipoprotein lipase, hepatic lipase, and endothelial lipase play a pivotal role in the clearance and remodelling of plasma lipoproteins. Their activity is governed at the level of gene transcription as well as via changes in enzyme activity by specific activator or inhibitor proteins.
Kersten, A.H.
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