Angiopoietin-like proteins: a comprehensive look [PDF]
Frontiers in Endocrinology, 2014 Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8.
Gaetano eSantulli
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Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer [PDF]
Cells, 2021 Secreted angiopoietin/angiopoietin-like (ANGPT/ANGPTL) proteins are involved in many biological processes. However, the role of these proteins in human breast cancers (BCs) remains largely unclear. Here, we conducted integrated omics analyses to evaluate
Hui Yang +5 more
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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer [PDF]
International Journal of Molecular Sciences, 2018 Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last decade, emerging evidences supported the autocrine and paracrine activity of the members of the Angiopoietin-like (ANGPTL) protein family in angiogenesis, inflammation and in the regulation of ...
Carmine Carbone +2 more
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Angiopoietin-like proteins inhibitors: New horizons in the treatment of atherogenic dyslipidemia and familial hypercholesterolemia [PDF]
Cardiology Journal, 2023 Angiopoietin-like proteins (ANGPTL) are involved in the regulation of numerous physiological and biochemical processes. ANGPTL3, 4 and 8, which are involved in the regulation of lipoprotein metabolism, are particularly important.
Stanisław Surma +2 more
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Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins [PDF]
Scientific ReportsHigh levels of HDL-C are correlated with a decreased risk of cardiovascular disease. HDL-C levels are modulated in part by the secreted phospholipase, endothelial lipase (EL), which hydrolyzes the phospholipids of HDL and decreases circulating HDL-C ...
Kelli L. Sylvers-Davie +3 more
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An Integrated Computational Analysis of High-Risk SNPs in Angiopoietin-like Proteins (ANGPTL3 and ANGPTL8) Reveals Perturbed Protein Dynamics Associated with Cancer [PDF]
Molecules, 2023 Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1–8) which play a pivotal role in the regulation of various pathophysiological processes.
Sajid Iqbal +4 more
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Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling [PDF]
eLife, 2015 Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin +18 more
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Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy [PDF]
MetabolitesAngiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local ...
Xinling Zhang +9 more
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Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy [PDF]
BiomedicinesAngiopoietins are crucial growth factors for maintaining a healthy, functional endothelium. Patients with type 2 diabetes (T2D) exhibit significant levels of angiogenic markers, particularly Angiopoietin-2, which compromises endothelial integrity and is ...
Eman Alshawaf +10 more
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Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders [PDF]
Expert Opinion on Therapeutic Targets, 2020 Introduction: Angiopoietin-like (ANGPTL) proteins belong to a family of eight secreted factors that are structurally related to proteins that modulate angiogenesis; these are commonly known as angiopoietins.
Marco Bruno Morelli, Gaetano Santulli
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