Results 11 to 20 of about 22,958 (190)

Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins [PDF]

Scientific Reports
High levels of HDL-C are correlated with a decreased risk of cardiovascular disease. HDL-C levels are modulated in part by the secreted phospholipase, endothelial lipase (EL), which hydrolyzes the phospholipids of HDL and decreases circulating HDL-C ...
Kelli L. Sylvers-Davie, Kaleb C. Bierstedt, Michael J. Schnieders, Brandon S. J. Davies   +3 more
doaj   +2 more sources

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling [PDF]

eLife, 2015
Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon   +18 more
doaj   +2 more sources

Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins [PDF]

JCI Insight
Fuel substrate switching between carbohydrates and fat is essential for maintaining metabolic homeostasis. During aerobic exercise, the predominant energy source gradually shifts from carbohydrates to fat.
Xiaomin Liu, Yiliang Zhang, Bingqian Han, Lin Li, Ying Li, Yifan Ma, Shijia Kang, Quan Li, Lingkai Kong, Kun Huang, Bao-liang Song, Yong Liu, Yan Wang   +12 more
doaj   +2 more sources

Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy [PDF]

Metabolites
Angiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local ...
Xinling Zhang, Dongang Liu, Yuting Qiu, Ruiyao Hu, Shiyu Chen, Yue Xu, Chenyan Qian, Lailing Du, Jinghua Yuan, Xiaoping Li   +9 more
doaj   +2 more sources

Angiopoietin-Like Proteins 2 and 3 in Children and Adolescents with Obesity and Their Relationship with Hypertension and Metabolic Syndrome [PDF]

International Journal of Hypertension, 2021
Background. Angiopoietin-like protein 2 (ANGPTL2) is one of the adipocyte-derived inflammatory factors which connects obesity to insulin resistance. ANGPTL3 has a direct role in regulation of lipid metabolism.
Zahra Arab Sadeghabadi, Mitra Nourbakhsh, Mohammad Alaee, Mona Nourbakhsh, Seyedeh Sara Ghorbanhosseini, Roya Sharifi, Maryam Razzaghy-Azar   +6 more
doaj   +2 more sources

Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5 [PDF]

Journal of Lipid Research
Fenofibrate and other fibrates are peroxisome proliferator–activated receptor alpha agonists that are used to lower plasma triglyceride (TG) levels. Although fibrates are effective in decreasing TG, their ability to reduce adverse cardiovascular events ...
Ye Yang, Sydney Smith, Yan Q. Chen, Hongxia Li, Eugene Y. Zhen, John H. Sloan, Robert W. Siegel, Yuewei Qian, Yi Wen, Hyesoo Jung, Julia L. Scheithauer, Sander Kersten, Stephen G. Young, Robert J. Konrad   +13 more
doaj   +2 more sources

Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS [PDF]

BMC Medicine
Background Alterations in lipid metabolism are manifestations of amyotrophic lateral sclerosis (ALS) that contribute to the risk and rate of progression.
Sruthi Sankari Krishnamurthy, Adriana Zardini Buzatto, Caley Campkin, Hans-Peter Müller, Diana Wiesner, Jochen Weishaupt, Veronika Klose, Maximilian Wiesenfarth, Zeynep Elmas, Christine Herrmann, Özlem Parlak, Kornelia Günther, Rami Saad, Ulrike Weiland, Luc Dupuis, Albert Ludolph, Liang Li, Jan Kassubek, Johannes Dorst, Francesco Roselli   +19 more
doaj   +2 more sources

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Journal of Lipid Research, 2021
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S.J. Davies   +4 more
doaj   +3 more sources

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity [PDF]

Nutrients, 2021
Magdalena Kuligowska-Prusińska, , Sypniewska Grazyna   +2 more
exaly   +2 more sources

Role of the angiopoietin-like protein family in the progression of NAFLD

Heliyon
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease, with a range of conditions including non-alcoholic fatty liver, non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC).
Xin Su, Qinchen Xu, Zigan Li, Yidan Ren, Qinlian Jiao, Lina Wang, Yunshan Wang   +6 more
doaj   +3 more sources