ANGPTL4 overexpression is associated with progression and poor prognoses of olfactory neuroblastoma [PDF]
Diagnostic PathologyObjective To analyze expression levels of angiopoietin‑like 4 (ANGPTL4) in olfactory neuroblastoma (ONB) to investigate the association between ANGPTL4 and ONB.
Yang Yunyun, Li Yahui, Piao Yingshi
doaj +2 more sources
Characterization of sexual dimorphism in ANGPTL4 levels and function
Journal of Lipid ResearchANGPTL4 is an attractive pharmacological target for lowering plasma triglycerides and cardiovascular risk. Since most preclinical studies on ANGPTL4 were performed in male mice, little is known about sexual dimorphism in ANGPTL4 regulation and function ...
Mingjuan Deng, Sander Kersten
exaly +3 more sources
Molecular Metabolism, 2018 Objectives: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA ...
Abhishek K Singh +2 more
exaly +3 more sources
Correction to "The Variant Senescence-Associated Secretory Phenotype Induced by Centrosome Amplification Constitutes a Pathway That Activates Hypoxia-Inducible Factor-1α". [PDF]
Aging CellAging Cell, Volume 25, Issue 6, June 2026.
europepmc +2 more sources
Propofol upregulates ANGPTL4 gene and protein expression to inhibit biological behavior of colon cancer cells [PDF]
Scientific ReportsPropofol, a clinically prevalent intravenous anesthetic, has garnered significant research interest in recent years due to its potential antitumor properties.
Jia Yang +5 more
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A Biomarker-Driven Ovary-Endometrium Organ-on-a-Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity. [PDF]
Adv Sci (Weinh)We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Kim SR +6 more
europepmc +2 more sources
Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism
Journal of Lipid Research, 2021 Triglycerides are carried in the bloodstream as the components of very low-density lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in muscle and adipose tissue by the enzyme lipoprotein lipase (LPL).
Sander Kersten
exaly +3 more sources
Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response [PDF]
Iranian Journal of Immunology, 2023 Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN ...
Dan Luo +6 more
doaj +1 more source
ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation
Scientific ReportsAcute rejection (AR) is a significant complication in liver transplantation, impacting graft function and patient survival. Kupffer cells (KCs), liver-specific macrophages, can polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, both of
Kezhen Zong, Dadi Peng, Zhongjun Wu
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Journal of Lipid Research, 2023 After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen +6 more
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