Results 1 to 10 of about 8,024 (115)
Integration of single-cell and bulk RNA sequencing data identified an aortic dissection-enriched ANGPTL4+ macrophage subpopulation [PDF]
Frontiers in ImmunologyBackgroundMacrophages play an indispensable role in the pathogenesis of aortic dissection (AD). However, the underlying molecular and cellular mechanisms remain incompletely understood.MethodsWe integrated six publicly available single-cell RNA ...
Zhenghao Li +7 more
doaj +2 more sources
Characterization of sexual dimorphism in ANGPTL4 levels and function
Journal of Lipid ResearchANGPTL4 is an attractive pharmacological target for lowering plasma triglycerides and cardiovascular risk. Since most preclinical studies on ANGPTL4 were performed in male mice, little is known about sexual dimorphism in ANGPTL4 regulation and function ...
Mingjuan Deng, Sander Kersten
exaly +3 more sources
Molecular Metabolism, 2018 Objectives: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA ...
Luis Varela +2 more
exaly +3 more sources
Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism
Journal of Lipid Research, 2021 Triglycerides are carried in the bloodstream as the components of very low-density lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in muscle and adipose tissue by the enzyme lipoprotein lipase (LPL).
Sander Kersten
exaly +3 more sources
Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response [PDF]
Iranian Journal of Immunology, 2023 Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN ...
Dan Luo +6 more
doaj +1 more source
ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation
Scientific ReportsAcute rejection (AR) is a significant complication in liver transplantation, impacting graft function and patient survival. Kupffer cells (KCs), liver-specific macrophages, can polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, both of
Zhongjun Wu, Liqing Jiang, Dadi Peng
exaly +2 more sources
Journal of Lipid Research, 2023 After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen +6 more
doaj +1 more source
ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The present study’s objective was to investigate the association between angiopoietin-like 4 (ANGPTL4) levels and the prognosis of Atrial fibrillation (AF), the causative effect in angiotensin II- (Ang II) induced AF, and its underlying ...
Xi Zhu +5 more
doaj +1 more source
Journal of Ovarian Research, 2022 Background Angiopoietin-like 4 (ANGPTL4) is highly expressed in a variety of neoplasms and promotes cancer progression. Nevertheless, the mechanism of ANGPTL4 in ovarian cancer (OC) metastasis remains unclear. This study aimeds to explore whether ANGPTL4
Yinping Liu +4 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2023 Proliferation and migration of epidermal stem cells (EpSCs) are essential for epithelialization during skin wound healing. Angiopoietin-like 4 (ANGPTL4) has been reported to play an important role in wound healing, but the mechanisms involved are not ...
Yang Yuan +11 more
doaj +1 more source