Results 31 to 40 of about 8,972 (208)
BMC Cancer, 2018 Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis.
T. Zhang +4 more
doaj +1 more source
The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells. [PDF]
PLoS ONE, 2017 Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type-specific and ...
Masafumi Nakamoto +7 more
doaj +1 more source
Inactivation of oligomeric LPL by ANGPTL4.
, 2023 20 nM LPL (A) or 200 nM LPL (B) was incubated in the presence of 1 μM ANGPTL4 and 10 IU/ml heparin (●) or 50 mg/ml BSA (■) or both (▼) in buffer A. Remaining LPL activity was determined by ITC using undiluted pooled human plasma (0.89 mM triglycerides, n
Kristofer Hiis-Hommuk (15213709) +8 more
core +1 more source
ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis [PDF]
Oncogene, 2013 Tumor suppressors with extracellular function are likely to have advantages as targets for cancer therapy, but few are known. Here, we focused on angiopoietin-like 4 (ANGPTL4), which is a secreted glycoprotein involved in lipoprotein metabolism and angiogenesis, is methylation-silenced in human cancers, but has unclear roles in cancer development and ...
E, Okochi-Takada +9 more
openaire +2 more sources
Role of Angiopoietin-like protein 4 (ANGPTL4) as a Predictive marker for Diabetic Nephropathy in type 2 Diabetes [PDF]
Al-Azhar International Medical Journal, 2022 Background: Angiopoietin-like protein 4 (ANGPTL4) is a glycoprotein that regulates LPL activity during fasting and thereby affects triglyceride metabolism.
Amr Rezk +3 more
doaj +1 more source
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
Journal of Lipid Research, 2016 LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk +5 more
doaj +1 more source
Variants inANGPTL4and the Risk of Coronary Artery Disease [PDF]
New England Journal of Medicine, 2016 Stitziel et al. report that a common gain-of-function genetic variant in LPL, which encodes lipoprotein lipase, is associated with a reduction in the risk of coronary artery disease. The authors speculate that therapeutic activation of this pathway might reduce the risk of coronary artery disease.
Morieri Mario Luca +2 more
openaire +9 more sources
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
Nature Communications, 2023 Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated.
Balkrishna Chaube +11 more
doaj +1 more source
Molecular Metabolism, 2017 Objective: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels.
Bodil Ingerslev +10 more
doaj +1 more source
Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. [PDF]
PLoS ONE, 2015 Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable.
Jian-Si Li +10 more
doaj +1 more source