Results 1 to 10 of about 1,112 (121)

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Journal of Advanced Research, 2023
Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Jian Tang, Zhongji Meng, Guo Xingrong
exaly   +3 more sources

ANGPTL8 in metabolic homeostasis: more friend than foe?

Open Biology, 2021
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 can be used as a bio-marker of these metabolic disorders related diseases, and the
Chang Guo, Xia Deng, Guoyue Yuan
exaly   +3 more sources

ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity. [PDF]

Eur J Clin Invest
Bariatric surgery induces early immunological and transcriptomic modulations in subcutaneous adipose tissue, suggesting a transient pro‐inflammatory state and tissue remodeling process in patients living with obesity. ANGPTL8 could play a role in improving metabolic homeostasis at early‐term after bariatric surgery offering new insights into adipose ...
Negro EM, Fernández-García P, Martin-Taboada M, Soria-Gondek A, Marín DR, Pérez PC, Cortijo SM, Antolinez MÁ, Mora I, Martínez L, Ros M, Villarroya F, Cereijo R, Sánchez-Infantes D, Corrales P.   +14 more
europepmc   +2 more sources

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2⁺PIRB⁺ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis. [PDF]

Adv Sci (Weinh)
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Wei S, Shou D, Huang S, Wang Y, Liu Q, Liu J, Lv X, Zeng Y, Wei L, Lin H, Chen J, Chen Y, Zhong H, Zhou Y, Ma W, Wang L, Qian G, Guo J, Sun D.   +18 more
europepmc   +2 more sources

ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells [PDF]

BMC Pregnancy and Childbirth
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and ...
Xinping Xie, Jianying Yan, Xiaoyun Chen, Lidan He, Jianbo Wu, Lin Lu   +5 more
doaj   +2 more sources

Association between serum ANGPLT8 levels and atherogenic index of plasma in Chinese patients with type 2 diabetes mellitus [PDF]

Frontiers in Cardiovascular Medicine
AimsAngiopoietin-like protein 8 (ANGPTL8), a secreted adipokine, has been reported to be associated with lipid and glucose metabolism. This study aimed to evaluate the association between circulating levels of ANGPTL8 and atherogenic risk, assessed by ...
Xiaoya Sun
doaj   +2 more sources

ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming [PDF]

Cellular and Molecular Life Sciences
Disruptions in energy metabolism within skeletal cells play a critical role in the pathogenesis of diabetic osteoporosis (DOP), primarily by affecting bone’s metabolic balance.
Peng Tuo, Wenbo Mu, Xinyu Bai, Suyin Wang, Liang Hu, Yining Xu, Ruopu Mao, Yixiang Liu, Yahong Yuan, Qiufang Zhang, Xingrong Guo, Shinan Ma, Xiaoli Wang   +12 more
doaj   +2 more sources

Associations Between APOC3 and ANGPTL8 Gene Polymorphisms With MASLD Risk and the Mediation Effect of Triglyceride on MASLD in the Chinese Population. [PDF]

J Cell Mol Med
ABSTRACT Apolipoprotein C3 (APOC3) and angiopoietin‐like protein 8 (ANGPTL8) genes are related to lipid metabolism. The relationships between single nucleotide polymorphisms (SNPs) in the APOC3 and ANGPTL8 genes with metabolic dysfunction‐associated steatotic liver disease (MASLD) remain controversial.
Pan J, Wang X, Zhang Y, Wang T, Lv S, Zhang X, Zhou Y, Peng T, Song Y.   +8 more
europepmc   +2 more sources

Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8

Frontiers in Molecular Neuroscience, 2018
Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver.
Rui Wang, Junhua Yuan, Yuan Liu
exaly   +3 more sources

ANGPTL8: An Important Regulator in Metabolic Disorders

Frontiers in Endocrinology, 2018
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved.
Daoquan Peng
exaly   +3 more sources