Results 1 to 10 of about 1,431 (182)

Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]

Jichu yixue yu linchuang
Objective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
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ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
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ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S] [PDF]

Journal of Lipid Research, 2017
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity.
Jorge F. Haller, Ivory J. Mintah, Lisa M. Shihanian, Panayiotis Stevis, David Buckler, Corey A. Alexa-Braun, Sandra Kleiner, Serena Banfi, Jonathan C. Cohen, Helen H. Hobbs, George D. Yancopoulos, Andrew J. Murphy, Viktoria Gusarova, Jesper Gromada   +13 more
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Angiopoietin-like protein 8 promotes phenotypic transformation of rat aorta vascular smooth muscle cells [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the role and mechanism of angiopoietin-like protein 8 (ANGPTL8) on phenotypic transformation of rat aorta vascular smooth muscle cells (VSMCs).
SUN Qiu-ju, JIAO Xiao-lu, YU Hua-hui, LI Fan, LYU Qian-wen, WANG Yu, QIN Yan-wen
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Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome

BMC Nephrology, 2021
Background This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.
Yue Li, Qingju Liu, Chengdong Kang, Weijing Cui, Zichuan Xu, Fu Zhong, Xia Gao   +6 more
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Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study

Cardiovascular Diabetology, 2018
Background Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have remarkably higher levels of ANGPTL8
Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li, Yanwen Qin   +5 more
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The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation

Cells, 2023
Background: Angiopoietin-like protein 8 (ANGPTL8) is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity and with IKK to modulate NF-κB activity.
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker   +15 more
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Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin

Frontiers in Endocrinology, 2023
Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults of Arab ethnicity. However, data on ANGPTL8 levels in adolescent obesity is lacking.
Maha M. Hammad, Arshad M. Channanath, Mohamed Abu-Farha, Abdur Rahman, Irina Al Khairi, Preethi Cherian, Tahani Alramah, Nada Alam-Eldin, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker   +10 more
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Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum

International Journal of Endocrinology, 2022
Gestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable.
Junhua Yuan, Di Zhang, Yunyang Wang, Zhen Zhu, Qian Lin, Manwen Li, Weizhen Zhong, Jing Han, Fengsen Xu, Jing Dong   +9 more
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Angiopoietin-like protein 8 promotes apoptosis of vascular smooth muscle cells through activating p53 signaling pathway [PDF]

Jichu yixue yu linchuang
Objective To investigate the mechanism by which angiopoietin-like protein 8 (ANGPTL8) regulates vascular smooth muscle cell (VSMCs) apoptosis. Methods An in vitro abdominal aortic aneurysm cell model was established by stimulating human VSMCs(HUSMCs ...
YU Huahui, DU Zhiyong, JIAO Xiaolu, LYU Qianwen, YANG Yunyun, HAN Lijie, QIN Yanwen
doaj   +1 more source