Results 31 to 40 of about 1,162 (153)

Liver-specific knockdown of ANGPTL8 alters the structure of the gut microbiota in mice

Annals of Microbiology, 2020
Purpose To investigate the effect of liver-specific knockdown of ANGPTL8 on the structure of the gut microbiota. Methods We constructed mice with liver-specific ANGPTL8 knockdown by using an adeno-associated virus serotype 8 (AAV8) system harbouring an ...
Yinlong Cheng, Yining Li, Yonghong Xiong, Yixin Zou, Siyu Chen, Wenxiang Zhang, Chang Liu, Yujie Shi   +7 more
doaj   +1 more source

Decreased circulating levels of ANGPTL8 in Graves’ disease patients [PDF]

Hormones, 2019
Angiopoietin-like protein 8 (ANGPTL8), a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. However, little is as yet known as to whether circulating ANGPTL8 levels are altered in thyroid dysfunction.
Li, Haoxiang, Xu, Mengjiao, Zhao, Li, Xia, Hong, Li, Yanyan, Hong, Xiafei, Deng, Xia, Yuan, Jing, Ding, Yi, Guo, Chang, Pan, Ruirong, Wang, Dong, Wang, Jifang, Yin, Wei, Yang, Ling, Yuan, Guoyue   +15 more
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Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant

Metabolites, 2023
ANGPTL8 is recognized as a regulator of lipid metabolism through its role in inhibiting lipoprotein lipase activity. ANGPTL8 gene variants, particularly rs2278426 leading to the R59W variant in the protein, have been associated with lipid traits in various ethnicities. We aimed to use metabolomics to understand the impact of the ANGPTL8 R59W variant on
Mohamed Abu-Farha, Shibu Joseph, Anwar Mohammad, Arshad Channanath, Ibrahim Taher, Fahd Al-Mulla, Muhammad Mujammami, Thangavel Alphonse Thanaraj, Jehad Abubaker, Anas M. Abdel Rahman   +9 more
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Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study [PDF]

Frontiers in Public Health, 2021
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with ...
Xiaoyu Meng, Xiaoyu Meng, Huajie Zou, Huajie Zou, Danpei Li, Danpei Li, Peng Yu, Peng Yu, Li Huang, Li Huang, Jianhua Zhang, Jianhua Zhang, Wenjun Li, Xuefeng Yu, Xuefeng Yu   +14 more
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Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome

BMC Nephrology, 2021
Background This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.
Yue Li, Qingju Liu, Chengdong Kang, Weijing Cui, Zichuan Xu, Fu Zhong, Xia Gao   +6 more
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Angptl8 mediates food-driven resetting of hepatic circadian clock in mice [PDF]

Nature Communications, 2019
AbstractDiurnal light-dark cycle resets the master clock, while timed food intake is another potent synchronizer of peripheral clocks in mammals. As the largest metabolic organ, the liver sensitively responds to the food signals and secretes hepatokines, leading to the robust regulation of metabolic and clock processes.
Siyu Chen, Mengyang Feng, Shiyao Zhang, Zhewen Dong, Yifan Wang, Wenxiang Zhang, Chang Liu   +6 more
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Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue [PDF]

Journal of Clinical Medicine, 2020
The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter is the least known.
Leonardo Catalano-Iniesta, Virginia Sánchez Robledo, María Carmen Iglesias-Osma, Amparo Galán Albiñana, Sixto Carrero, Enrique J. Blanco, Marta Carretero-Hernández, José Carretero, María José García-Barrado   +8 more
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Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study

Cardiovascular Diabetology, 2018
Background Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have remarkably higher levels of ANGPTL8
Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li, Yanwen Qin   +5 more
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The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation

Cells, 2023
Background: Angiopoietin-like protein 8 (ANGPTL8) is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity and with IKK to modulate NF-κB activity.
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker   +15 more
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Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition [PDF]

Chemistry and Physics of Lipids, 2017
Angiopoietin-like 8 (Angptl8) inhibits lipolysis in the circulation together with Angplt3 and controls post-prandial fat storage in white adipose tissue (WAT). It is strongly induced by insulin in vivo in WAT and in vitro in adipocytes. In this study we addressed the function of Angptl8 in adipocytes by its stable lentivirus-mediated knock-down in 3T3 ...
Mysore, Raghavendra, Liebisch, Gerhard, Zhou, You, Olkkonen, Vesa M., Haridas, P. A. Nidhina   +4 more
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