Results 31 to 40 of about 1,199 (160)
Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]
Cell & BioscienceCytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su +7 more
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Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8 [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Context ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8
Federico Oldoni +7 more
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Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue [PDF]
Journal of Clinical Medicine, 2020 The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter is the least known.
Leonardo Catalano-Iniesta +8 more
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Perspectives on the Activities of ANGPTL8/Betatrophin [PDF]
Cell, 2014 In this issue of Cell, Gusarova et al. (2014) show that deletion of ANGPTL8 in mice does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961. They also show that overexpression of human ANGPTL8 in mouse liver leads to elevated serum
Yi, Peng +2 more
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Oncogenesis, 2023 The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood.
Yujiu Gao +16 more
doaj +1 more source
ANGPTL8 has both endocrine and autocrine effects on substrate utilization [PDF]
JCI Insight, 2020 The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage ...
Federico Oldoni +5 more
openaire +3 more sources
Circulating ANGPTL8 as a Potential Protector of Metabolic Complications in Patients with Psoriasis
Journal of Clinical Medicine, 2023 Angiopoietin-like protein 8 (ANGPTL8) exerts pleiotropic effects, taking part in lipid and carbohydrate metabolism, inflammation, hematopoiesis and oncogenesis. So far, the exact molecular targets of ANGPTL8 remain poorly defined. We aimed to evaluate the serum concentration of ANGPTL8 in individuals with psoriasis and examine how systemic therapy ...
Anna Baran +5 more
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Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism
BioMed Research International, 2019 Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Longyan Yang +5 more
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The predictive diagnosis for ANGPTL8 level in women with T2DM
International journal of health sciences, 2022 Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia, is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications.
Aws Safaa Fadhel, Manal F. AL-Khakani
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Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study [PDF]
Frontiers in Public Health, 2021 Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with ...
Xiaoyu Meng +14 more
openaire +3 more sources