Results 31 to 40 of about 1,431 (182)

The predictive diagnosis for ANGPTL8 level in women with T2DM

International journal of health sciences, 2022
Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia,  is an increasing health burden.
Fadhel, Aws Safaa, Manal F. AL-Khakani, AL-Khakani, Manal F., Aws Safaa Fadhel   +3 more
core   +2 more sources

ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming [PDF]

Cellular and Molecular Life Sciences
Disruptions in energy metabolism within skeletal cells play a critical role in the pathogenesis of diabetic osteoporosis (DOP), primarily by affecting bone’s metabolic balance.
Peng Tuo, Wenbo Mu, Xinyu Bai, Suyin Wang, Liang Hu, Yining Xu, Ruopu Mao, Yixiang Liu, Yahong Yuan, Qiufang Zhang, Xingrong Guo, Shinan Ma, Xiaoli Wang   +12 more
doaj   +2 more sources

Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women

Metabolites, 2022
Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation.
Magdalena Krintus, Murawska, Karolina, Magdalena Kuligowska-Prusinska, Krintus, Magdalena, Anna Stefanska, Sypniewska, Grazyna, Kuligowska-Prusinska, Magdalena, Katarzyna Bergmann, Karolina Murawska, Stefanska, Anna, Bergmann, Katarzyna, Grazyna Sypniewska   +11 more
core   +4 more sources

Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis [PDF]

Journal of Neuroinflammation
Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain.
Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo   +18 more
doaj   +2 more sources

Associations Between APOC3 and ANGPTL8 Gene Polymorphisms With MASLD Risk and the Mediation Effect of Triglyceride on MASLD in the Chinese Population. [PDF]

J Cell Mol Med
ABSTRACT Apolipoprotein C3 (APOC3) and angiopoietin‐like protein 8 (ANGPTL8) genes are related to lipid metabolism. The relationships between single nucleotide polymorphisms (SNPs) in the APOC3 and ANGPTL8 genes with metabolic dysfunction‐associated steatotic liver disease (MASLD) remain controversial.
Pan J, Wang X, Zhang Y, Wang T, Lv S, Zhang X, Zhou Y, Peng T, Song Y.   +8 more
europepmc   +2 more sources

Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background ANGPTL8 (angiopoietin‐like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid‐independent mechanisms, remains unclear.
Huimin Ye, Qiang Zhu, Qunchuan Zong, Shanyu Luo, Zonghong Ji, Ruixia Zhang, Huajie Zou   +6 more
doaj   +2 more sources

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +2 more sources

Positive correlation of ANGPTL8 expression in human visceral adipose tissue with body mass index

Journal of the Formosan Medical Association
Background: Angiopoietin-like protein 8 (ANGPTL8) is an important regulator of lipid metabolism. We aimed to investigate the difference of ANGPTL8 expression in different depots of adipose tissues between individuals with and without obesity, and its ...
Shiau-Mei Chen, Tse-Ying Huang, Wei-Jei Lee, Lee-Ming Chuang, Tien-Jyun Chang   +4 more
doaj   +2 more sources

Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]

Cell & Bioscience
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen   +7 more
doaj   +2 more sources

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Mediators of Inflammation, 2019
Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods.
Danlan Pu, Ling Li, Jingxia Yin, Rui Liu, Gangyi Yang, Yong Liao, Qinan Wu   +6 more
doaj   +2 more sources