Results 51 to 60 of about 1,199 (160)

Enriched Metabolic Phenotyping Refines Phenotypic Resolution of Type 2 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6674-6686, August 2026.
ABSTRACT Aims Data‐driven clustering studies of type 2 diabetes (T2D) based on limited routine clinical variables have reproducibly described major metabolic subgroups, including severe insulin‐deficient diabetes (SIDD), severe insulin‐resistant diabetes (SIRD), mild obesity‐related diabetes and mild age‐related diabetes.
Min Wang, Yang Ou, Heng Su, Bing Zhang, Ben Niu, Anwar Ahmed, Guoqiang Xing   +6 more
wiley   +1 more source

Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Lipids in Health and Disease, 2018
Background Angiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans.
Song Yang, Xiaolu Jiao, Xiaoguang Huo, Miaomiao Zhu, Yi Wang, Xiangnan Fang, Yunyun Yang, Weidong Yue, Yanwen Qin   +8 more
doaj   +1 more source

Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. [PDF]

PLoS ONE, 2016
OBJECTIVE:ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well as glucose homeostasis. This study was designed to evaluate the level of ANGPTL8 in obese and non-obese subjects before and after ...
Mohamed Abu-Farha, Devarajan Sriraman, Preethi Cherian, Irina AlKhairi, Naser Elkum, Kazem Behbehani, Jehad Abubaker   +6 more
doaj   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β ...
Nastaran Monzavi, Seyed Jalal Zargar, Nematollah Gheibi, Mehdi Azad, Babak Rahmani   +4 more
doaj   +1 more source

Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk

Depression and Anxiety, Volume 2026, Issue 1, 2026.
The comorbidity of mood disorders (MDs), represented by depression and anxiety, with chronic somatic diseases (CDs), particularly cardiometabolic conditions, poses a significant global public health challenge, markedly increasing the risk of adverse prognoses and all‐cause mortality.
Hongzhen Du, Gangqiang Du, Qian Zhang, Yixuan Zhao, Jilin Fan, Yufeng Zhou, Zihao Sun, Chen Li, Wei Li, Chandra Bose   +9 more
wiley   +1 more source

Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

Cardiovascular Diabetology, 2021
Background ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the ...
Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang, Jianhua Zhang, Wenjun Li, Zhelong Liu, Xuefeng Yu   +19 more
doaj   +1 more source

Adipokine in Metabolic Liver Disease: Adipo–Brain–Liver Cross talk

International Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Purpose Adipokines play a key role in the interaction between the brain, liver, and adipose tissue. In this review, we selected adipokines with wide central receptor expression and summarized their indirect regulation on liver metabolism by acting on specific neurons and inducing neuropeptide production.
Yule Su, Yiping Yang, Wenjuan Sun, Zhouxi Yu, Yilin Wang, Shixin Liu, Ziyi Chen, Yanfei Li, Xi Yang, Junyan Liu, Caikun Han, Yaqin Wang, Junhua Yuan, Suraiya Saleem   +13 more
wiley   +1 more source

Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Our research examined how leukocyte immunoglobulin‐like receptor B2 (LILRB2) impacts macrophage extracellular trap (MET) formation in foam macrophages within atherosclerosis (AS). Results highlighted LILRB2's key role in AS, suggesting it may influence PI3K/AKT signaling to spur MET formation.
Yuanyong Jiao, Rui Hu, Liang Gui, Suyu Miu, Xiwei Zhang, Junjie Zou   +5 more
wiley   +1 more source

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source