Results 51 to 60 of about 1,534 (183)
ANGPTL8 has both endocrine and autocrine effects on substrate utilization [PDF]
JCI Insight, 2020 The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage ...
Federico Oldoni +5 more
openaire +3 more sources
Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity
, 2021 Angiopoietin-like protein 8 (ANGPTL8) is an hepatokine altered in several metabolic conditions, such as obesity, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease (NAFLD).
Victoria Catalán +12 more
core +1 more source
Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism
BioMed Research International, 2019 Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Longyan Yang +5 more
openaire +2 more sources
Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study [PDF]
Frontiers in Public Health, 2021 Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with ...
Xiaoyu Meng +14 more
openaire +3 more sources
International Journal of Endocrinology, 2022 Gestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable.
Junhua Yuan +9 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults of Arab ethnicity. However, data on ANGPTL8 levels in adolescent obesity is lacking.
Maha M. Hammad +10 more
doaj +1 more source
, 2023 Tingxue Zhang,1,2 Yilin Hou,1,2 Min Liu,2 Xiaoyu Hou,1,2 Yong Tang,2 Luping Ren,2 Guangyao Song1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General ...
Zhang T +6 more
core
, 2016 A: Level of full length form of ANGPTL8 in non-obese subjects before and after three months of exercise training. B: Level of C-terminal 139–198 form of ANGPTL8 in non-obese subjects before and after three months of exercise training.
Mohamed Abu-Farha (25322) +6 more
core +1 more source
Cardiovascular Diabetology, 2018 Background Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Tianpeng Zheng +6 more
doaj +1 more source
Lipids in Health and Disease, 2018 Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia.
Mengdie Luo +4 more
doaj +1 more source