Results 51 to 60 of about 1,162 (153)

Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism

Lipids in Health and Disease, 2018
Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia.
Mengdie Luo, Xin Su, Yuhong Yi, Yang Yang, Daoquan Peng   +4 more
doaj   +1 more source

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Journal of Lipid Research, 2021
High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S.J. Davies   +4 more
doaj   +1 more source

Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Lipids in Health and Disease, 2018
Background Angiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans.
Song Yang, Xiaolu Jiao, Xiaoguang Huo, Miaomiao Zhu, Yi Wang, Xiangnan Fang, Yunyun Yang, Weidong Yue, Yanwen Qin   +8 more
doaj   +1 more source

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β ...
Nastaran Monzavi, Seyed Jalal Zargar, Nematollah Gheibi, Mehdi Azad, Babak Rahmani   +4 more
doaj   +1 more source

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

Nature Communications, 2023
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (
Dan-Pei Li, Li Huang, Ran-Ran Kan, Xiao-Yu Meng, Shu-Yun Wang, Hua-Jie Zou, Ya-Ming Guo, Pei-Qiong Luo, Li-Meng Pan, Yu-Xi Xiang, Bei-Bei Mao, Yu-Yu Xie, Zhi-Han Wang, Min Yang, Rui He, Yan Yang, Zhe-Long Liu, Jun-Hui Xie, De-Lin Ma, Ben-Ping Zhang, Shi-Ying Shao, Xi Chen, Si-Miao Xu, Wen-Tao He, Wen-Jun Li, Yong Chen, Xue-Feng Yu   +26 more
doaj   +1 more source

Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China

Frontiers in Endocrinology, 2018
Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Liuxue Yang, Jianfei Song, Xiaoxi Zhang, Liuping Xiao, Xueping Hu, Haidong Pan, Linyuan Qin, Hongbo Liu, Bo Ge, Tianpeng Zheng, Tianpeng Zheng   +10 more
doaj   +1 more source

Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Our research examined how leukocyte immunoglobulin‐like receptor B2 (LILRB2) impacts macrophage extracellular trap (MET) formation in foam macrophages within atherosclerosis (AS). Results highlighted LILRB2's key role in AS, suggesting it may influence PI3K/AKT signaling to spur MET formation.
Yuanyong Jiao, Rui Hu, Liang Gui, Suyu Miu, Xiwei Zhang, Junjie Zou   +5 more
wiley   +1 more source

Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women

Metabolites, 2022
Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear.
Anna Stefanska, Katarzyna Bergmann, Magdalena Krintus, Magdalena Kuligowska-Prusinska, Karolina Murawska, Grazyna Sypniewska   +5 more
openaire   +3 more sources

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

Circulating ANGPTL8 as a Potential Protector of Metabolic Complications in Patients with Psoriasis

Journal of Clinical Medicine, 2023
Angiopoietin-like protein 8 (ANGPTL8) exerts pleiotropic effects, taking part in lipid and carbohydrate metabolism, inflammation, hematopoiesis and oncogenesis. So far, the exact molecular targets of ANGPTL8 remain poorly defined. We aimed to evaluate the serum concentration of ANGPTL8 in individuals with psoriasis and examine how systemic therapy ...
Anna Baran, Julita Anna Krahel, Julia Nowowiejska, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak   +5 more
openaire   +2 more sources