Results 71 to 80 of about 1,431 (182)

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer ofβ-Cell Proliferation [PDF]

Journal of Diabetes Research, 2016
Diabetes is a global health problem that is caused by impaired insulin production from pancreaticβ-cells. Efforts to regenerateβ-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induceβ-cells regeneration.
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker   +2 more
openaire   +3 more sources

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice

Clinical Science, 2023
Abstract Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell proliferation and migration. Clinical studies have indicated that circulating ANGPTL8 levels are increased in patients with thoracic aortic dissection (TAD).
Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin   +14 more
openaire   +2 more sources

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5985-5995, October 2025.
Abstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q. Chen, Ajit Regmi, William C. Roell, Melissa K. Thomas, Mark L. Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J. Konrad   +12 more
wiley   +1 more source

Correction: ANGPTL8 is a negative regulator in pathological cardiac hypertrophy. [PDF]

Cell Death Dis
Hu L, Wei J, Zhang Y, Wang Z, Tang J, Tang J, Gao Y, Zhang X, Li Y, Liu Y, Ma S, Guo X, Zhang Q.   +12 more
europepmc   +3 more sources

A Conserved FABP5high Macrophage Subset Promotes Fibrosis and Carcinogenesis in Advanced Liver Disease

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims The relationship between chronic liver disease and liver cancer remains poorly understood, and treatment options for advanced liver disease remain limited. This study aims to elucidate the dynamic evolution of cellular and molecular alterations from normal liver to diseased liver.
Wenhao Ge, Lifeng Ma, Yu Huang, Weigao E, Shujing Lai, Bijun Cui, Jingjing Wang, Yutian Ji, Daiyuan Liu, Song Ye, Yang Kong, Jiarong Zhou, Chengxuan Yu, Yingsheng Wu, Qiang Sun, Dongkai Zhou, Wei Zhu, Yuan Ding, Xiaoping Han, Guoji Guo, Weilin Wang   +20 more
wiley   +1 more source

Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

Cardiovascular Diabetology, 2021
Background ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the ...
Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang, Jianhua Zhang, Wenjun Li, Zhelong Liu, Xuefeng Yu   +19 more
doaj   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1215-1228, July 2025.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Immunity and cancer interplay are central to tumor progression. This review explores how tumor cells exploit extracellular vesicles (EVs) to orchestrate immune evasion. Tumor‐derived EVs (TEVs) transport immunomodulatory cargo to shape immune differentiation, activation, and function.
Xuanfan Liu, Kenneth K.W. To, Qinsong Zeng, Liwu Fu   +3 more
wiley   +1 more source