Results 71 to 80 of about 1,162 (153)

Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis

Obesity, Volume 33, Issue 3, Page 522-536, March 2025.
Abstract Objective Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear.
Manal Al Dow, Blandine Secco, Mathilde Mouchiroud, Marianne Rochette, Gustavo R. Gilio, Mickael Massicard, Marilou Hardy, Yves Gélinas, William T. Festuccia, Mathieu C. Morissette, Venkata S. K. Manem, Mathieu Laplante   +11 more
wiley   +1 more source

Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D [PDF]

Lipids in Health and Disease, 2016
Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase.
Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker   +8 more
openaire   +2 more sources

A Complex Network of Obesity‐Risk Genes Revealed by Systematic Bioinformatics and Single‐Cell Transcriptomic Analyses

Journal of Obesity, Volume 2025, Issue 1, 2025.
The development of obesity is closely linked to genetic factors. Despite the identification of numerous genes associated with an increased risk of obesity in humans, a comprehensive understanding of their biological roles has not been achieved. In our extensive bioinformatics study, we identified 802 core genes implicated in obesity.
Yuenan Liu, Haolin Yuan, Junhui Hu, Xu Xu, Shankai Yin, Yiming Hu, Feng Liu, Mayank Choubey   +7 more
wiley   +1 more source

Bacteria-Derived Recombinant Human ANGPTL8/Betatrophin Significantly Increases the Level of Triglyceride [PDF]

The Protein Journal, 2019
Abstract ANGPTL8/Betatrophin has been implicated in the regulation of both glucose and triglyceride metabolism. However, its role in regulating glucose metabolism by promoting β cell proliferation remains controversial, and its physiological functions and molecular targets are largely unknown.
Fangfang Xu, Yuqing Chen, Nan Wang, Kai Sun   +3 more
openaire   +2 more sources

Genomic responses to climatic challenges in beef cattle: A review

Animal Genetics, Volume 55, Issue 6, Page 854-870, December 2024.
Abstract Climate change is a major concern for the near future and for livestock breeding. Cattle breeding, due to its greenhouse gas emissions, is one of the most implicated industries. Consequently, the main future goals are to breed animals resilient to climate change, with the aim of lowering the livestock impact on the environment and selecting ...
Daniele Colombi, Francesco Perini, Stefano Bettini, Salvatore Mastrangelo, Fabio Abeni, Giuseppe Conte, Donata Marletta, Martino Cassandro, Umberto Bernabucci, Roberta Ciampolini, Emiliano Lasagna   +10 more
wiley   +1 more source

Transcriptomic Analysis of Early‐Stage Basal Cell Carcinomas in Murine Skin Following Topical Treatments With Ablative Fractional Laser and Vismodegib

Experimental Dermatology, Volume 33, Issue 10, October 2024.
ABSTRACT Recent studies have demonstrated that ablative fractional laser (AFL) can inhibit the hedgehog pathway, enhance immune infiltration and clear basal cell carcinomas (BCCs) in murine models. In this study, we applied RNA sequencing to further characterise the impact of AFL on the transcriptome of murine skin containing early‐stage microscopic ...
Kristian Kåber Pedersen, Merete Hædersdal, Uffe Høgh Olesen, Thomas Litman   +3 more
wiley   +1 more source

Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes.

PLoS ONE, 2021
Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed.
Marina Harada, Tadashi Yamakawa, Rie Kashiwagi, Akeo Ohira, Mai Sugiyama, Yasuyuki Sugiura, Yoshinobu Kondo, Yasuo Terauchi   +7 more
doaj   +1 more source

Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer

Cancer Communications, Volume 44, Issue 8, Page 855-878, August 2024.
Abstract Background Lymph node metastasis (LNM) is the primary mode of metastasis in gastric cancer (GC). However, the precise mechanisms underlying this process remain elusive. Tumor cells necessitate lipid metabolic reprogramming to facilitate metastasis, yet the role of lipoprotein lipase (LPL), a pivotal enzyme involved in exogenous lipid uptake ...
Jian Xiao, Shuqing Cao, Jiawei Wang, Pengyu Li, Quan Cheng, Xinyi Zhou, Jiacheng Dong, Yuan Li, Xinyu Zhao, Zekuan Xu, Li Yang   +10 more
wiley   +1 more source

Endothelial dysfunction: molecular mechanisms and clinical implications

MedComm, Volume 5, Issue 8, August 2024.
Endothelial dysfunction is commonly linked to various disease states resulting from an imbalance in the production of vasodilators and vasoconstrictors, among other factors. Human diseases associated with endothelial dysfunction include atherosclerosis, diabetes, metabolic syndrome, neurodegenerative diseases, chronic kidney disease, hypertension ...
Xia Wang, Ben He
wiley   +1 more source

Whole‐blood transcriptome analysis reveals distinct gene expression signatures in paediatric patients with sickle cell anaemia before and after exercise

British Journal of Haematology, Volume 205, Issue 1, Page 320-328, July 2024.
The present study analysed the whole‐blood transcriptome profile before and after acute exercise in paediatric patients with sickle cell anaemia (SCA) compared to healthy controls. At baseline, SCA patients exhibited up‐regulated gene pathways associated with gas transport in erythrocytes.
Abel Plaza‐Florido, Robert I. Liem, Fadia Haddad, Shlomit Radom‐Aizik   +3 more
wiley   +1 more source