Results 71 to 80 of about 1,534 (183)

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β ...
Nastaran Monzavi, Seyed Jalal Zargar, Nematollah Gheibi, Mehdi Azad, Babak Rahmani   +4 more
doaj   +1 more source

Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

Cardiovascular Diabetology, 2021
Background ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the ...
Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang, Jianhua Zhang, Wenjun Li, Zhelong Liu, Xuefeng Yu   +19 more
doaj   +1 more source

The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer ofβ-Cell Proliferation [PDF]

Journal of Diabetes Research, 2016
Diabetes is a global health problem that is caused by impaired insulin production from pancreaticβ-cells. Efforts to regenerateβ-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induceβ-cells regeneration.
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker   +2 more
openaire   +3 more sources

Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Our research examined how leukocyte immunoglobulin‐like receptor B2 (LILRB2) impacts macrophage extracellular trap (MET) formation in foam macrophages within atherosclerosis (AS). Results highlighted LILRB2's key role in AS, suggesting it may influence PI3K/AKT signaling to spur MET formation.
Yuanyong Jiao, Rui Hu, Liang Gui, Suyu Miu, Xiwei Zhang, Junjie Zou   +5 more
wiley   +1 more source

Image6_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.JPEG

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

Image4_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5985-5995, October 2025.
Abstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q. Chen, Ajit Regmi, William C. Roell, Melissa K. Thomas, Mark L. Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J. Konrad   +12 more
wiley   +1 more source

A Conserved FABP5high Macrophage Subset Promotes Fibrosis and Carcinogenesis in Advanced Liver Disease

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims The relationship between chronic liver disease and liver cancer remains poorly understood, and treatment options for advanced liver disease remain limited. This study aims to elucidate the dynamic evolution of cellular and molecular alterations from normal liver to diseased liver.
Wenhao Ge, Lifeng Ma, Yu Huang, Weigao E, Shujing Lai, Bijun Cui, Jingjing Wang, Yutian Ji, Daiyuan Liu, Song Ye, Yang Kong, Jiarong Zhou, Chengxuan Yu, Yingsheng Wu, Qiang Sun, Dongkai Zhou, Wei Zhu, Yuan Ding, Xiaoping Han, Guoji Guo, Weilin Wang   +20 more
wiley   +1 more source

Image8_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source