Results 91 to 100 of about 1,431 (182)

Image3_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer

Cancer Communications, Volume 44, Issue 8, Page 855-878, August 2024.
Abstract Background Lymph node metastasis (LNM) is the primary mode of metastasis in gastric cancer (GC). However, the precise mechanisms underlying this process remain elusive. Tumor cells necessitate lipid metabolic reprogramming to facilitate metastasis, yet the role of lipoprotein lipase (LPL), a pivotal enzyme involved in exogenous lipid uptake ...
Jian Xiao, Shuqing Cao, Jiawei Wang, Pengyu Li, Quan Cheng, Xinyi Zhou, Jiacheng Dong, Yuan Li, Xinyu Zhao, Zekuan Xu, Li Yang   +10 more
wiley   +1 more source

Endothelial dysfunction: molecular mechanisms and clinical implications

MedComm, Volume 5, Issue 8, August 2024.
Endothelial dysfunction is commonly linked to various disease states resulting from an imbalance in the production of vasodilators and vasoconstrictors, among other factors. Human diseases associated with endothelial dysfunction include atherosclerosis, diabetes, metabolic syndrome, neurodegenerative diseases, chronic kidney disease, hypertension ...
Xia Wang, Ben He
wiley   +1 more source

Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4

, 2022
Angiopoietin-like proteins, ANGPTL3, ANGPTL4, and ANGPTL8, are involved in regulating plasma lipids. In vitro and animal-based studies point to LPL and endothelial lipase (EL, LIPG) as key targets of ANGPTLs.
Fredrik Landfors, Kersten, Sander,, Landfors, Fredrik, Chorell, Elin, Landfors, Fredrik,, Chorell, Elin,, Sander Kersten, Elin Chorell, Kersten, Sander   +8 more
core   +1 more source

Whole‐blood transcriptome analysis reveals distinct gene expression signatures in paediatric patients with sickle cell anaemia before and after exercise

British Journal of Haematology, Volume 205, Issue 1, Page 320-328, July 2024.
The present study analysed the whole‐blood transcriptome profile before and after acute exercise in paediatric patients with sickle cell anaemia (SCA) compared to healthy controls. At baseline, SCA patients exhibited up‐regulated gene pathways associated with gas transport in erythrocytes.
Abel Plaza‐Florido, Robert I. Liem, Fadia Haddad, Shlomit Radom‐Aizik   +3 more
wiley   +1 more source

Data_Sheet_3_Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis.PDF

, 2018
Angiopoietin like protein 8 (ANGPTL8) is a newly identified hormone with unique nature due to its ability to regulate both glucose and lipid metabolic pathways.
Samar H. K. Tareen (6110555), Elisa Cirillo (5058758), Jamil Ahmad (327791), Susan L. Coort (493712), Amnah Siddiqa (6110552), Amjad Ali (51075), Martina Kutmon (99935), Chris T. Evelo (117440), Lars M. T. Eijssen (117447)   +8 more
core   +1 more source

MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes

, 2017
Context Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design We addressed the correlation between ANGPTL8 messenger RNA ...
José M Fernández-Real, Francisco J Ortega, Pamela Fischer-Posovszky, Vesa M Olkkonen, Hanna Savolainen-Peltonen, P A Nidhina Haridas, Maria Ahonen, Jèssica Latorre, Raghavendra Mysore, Martin Wabitsch   +9 more
core   +1 more source

Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
ANGPTL8, expressed mainly in the liver and adipose tissue, regulates the activity of lipoprotein lipase (LPL) present in the extracellular space and triglyceride (TG) metabolism through its interaction with ANGPTL3 and ANGPTL4. Whether intracellular ANGPTL8 can also exert effects in tissues where it is expressed is uncertain. ANGPTL8 expression was low
Anindya, Ghosh, Yat Hei, Leung, Jeffrey, Yu, Robert, Sladek, Isabelle, Chénier, Abel K, Oppong, Marie-Line, Peyot, S R Murthy, Madiraju, Irina, Al-Khairi, Thangavel Alphonse, Thanaraj, Jehad, Abubaker, Fahd, Al-Mulla, Marc, Prentki, Mohamed, Abu-Farha   +13 more
openaire   +2 more sources

Presentation_1_Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis.PDF

, 2018
Angiopoietin like protein 8 (ANGPTL8) is a newly identified hormone with unique nature due to its ability to regulate both glucose and lipid metabolic pathways.
Samar H. K. Tareen (6110555), Elisa Cirillo (5058758), Jamil Ahmad (327791), Susan L. Coort (493712), Amnah Siddiqa (6110552), Amjad Ali (51075), Martina Kutmon (99935), Chris T. Evelo (117440), Lars M. T. Eijssen (117447)   +8 more
core   +1 more source

DataSheet1_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.xlsx

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source