Results 81 to 90 of about 1,431 (182)

Análisis de la expresión de ANGPTL8 en tejido adiposo humano y su posible implicación en obesidad

, 2018
[ES]Introducción: El tejido adiposo está implicado en patologías como obesidad y diabetes. A parte de su papel en el almacenamiento energético, es considerado como un órgano endocrino capaz de sintetizar y liberar adipoquinas.
Catalano-Iniesta, Leonardo
core   +1 more source

Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis

Obesity, Volume 33, Issue 3, Page 522-536, March 2025.
Abstract Objective Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear.
Manal Al Dow, Blandine Secco, Mathilde Mouchiroud, Marianne Rochette, Gustavo R. Gilio, Mickael Massicard, Marilou Hardy, Yves Gélinas, William T. Festuccia, Mathieu C. Morissette, Venkata S. K. Manem, Mathieu Laplante   +11 more
wiley   +1 more source

Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes.

PLoS ONE, 2021
Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed.
Marina Harada, Tadashi Yamakawa, Rie Kashiwagi, Akeo Ohira, Mai Sugiyama, Yasuyuki Sugiura, Yoshinobu Kondo, Yasuo Terauchi   +7 more
doaj   +1 more source

A Complex Network of Obesity‐Risk Genes Revealed by Systematic Bioinformatics and Single‐Cell Transcriptomic Analyses

Journal of Obesity, Volume 2025, Issue 1, 2025.
The development of obesity is closely linked to genetic factors. Despite the identification of numerous genes associated with an increased risk of obesity in humans, a comprehensive understanding of their biological roles has not been achieved. In our extensive bioinformatics study, we identified 802 core genes implicated in obesity.
Yuenan Liu, Haolin Yuan, Junhui Hu, Xu Xu, Shankai Yin, Yiming Hu, Feng Liu, Mayank Choubey   +7 more
wiley   +1 more source

Image8_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Genomic responses to climatic challenges in beef cattle: A review

Animal Genetics, Volume 55, Issue 6, Page 854-870, December 2024.
Abstract Climate change is a major concern for the near future and for livestock breeding. Cattle breeding, due to its greenhouse gas emissions, is one of the most implicated industries. Consequently, the main future goals are to breed animals resilient to climate change, with the aim of lowering the livestock impact on the environment and selecting ...
Daniele Colombi, Francesco Perini, Stefano Bettini, Salvatore Mastrangelo, Fabio Abeni, Giuseppe Conte, Donata Marletta, Martino Cassandro, Umberto Bernabucci, Roberta Ciampolini, Emiliano Lasagna   +10 more
wiley   +1 more source

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

, 2017
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as a negative feedback regulator in TNFα-triggered NF-κB ...
Wanyao Yan, Xinran Liu, Ling Zheng, Xian Guo, Yu Zhang, Weili Xue, Bin Wu, Lianqi Huang, Shun Wang, Yan Chen, Kun Huang, Liang Ma, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Qiaoqiao Zhou   +15 more
core   +1 more source

Image9_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

Journal of Immunology Research, 2020
Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases.
Drahomira Holmannova, Lenka Borska, Ctirad Andrys, Pavel Borsky, Jan Kremlacek, Kvetoslava Hamakova, Vit Rehacek, Andrea Malkova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Zdenek Fiala   +11 more
doaj   +1 more source

Transcriptomic Analysis of Early‐Stage Basal Cell Carcinomas in Murine Skin Following Topical Treatments With Ablative Fractional Laser and Vismodegib

Experimental Dermatology, Volume 33, Issue 10, October 2024.
ABSTRACT Recent studies have demonstrated that ablative fractional laser (AFL) can inhibit the hedgehog pathway, enhance immune infiltration and clear basal cell carcinomas (BCCs) in murine models. In this study, we applied RNA sequencing to further characterise the impact of AFL on the transcriptome of murine skin containing early‐stage microscopic ...
Kristian Kåber Pedersen, Merete Hædersdal, Uffe Høgh Olesen, Thomas Litman   +3 more
wiley   +1 more source