Results 81 to 90 of about 1,534 (183)
Angptl8 mediates food-driven resetting of hepatic circadian clock in mice [PDF]
Nature Communications, 2019 AbstractDiurnal light-dark cycle resets the master clock, while timed food intake is another potent synchronizer of peripheral clocks in mammals. As the largest metabolic organ, the liver sensitively responds to the food signals and secretes hepatokines, leading to the robust regulation of metabolic and clock processes.
Siyu Chen +6 more
openaire +3 more sources
Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1215-1228, July 2025.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
, 2021 The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584) +4 more
core +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang +13 more
wiley +1 more source
, 2021 The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584) +4 more
core +1 more source
Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion
Advanced Science, Volume 12, Issue 12, March 27, 2025.Immunity and cancer interplay are central to tumor progression. This review explores how tumor cells exploit extracellular vesicles (EVs) to orchestrate immune evasion. Tumor‐derived EVs (TEVs) transport immunomodulatory cargo to shape immune differentiation, activation, and function.
Xuanfan Liu +3 more
wiley +1 more source
MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes
, 2017 Context Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design We addressed the correlation between ANGPTL8 messenger RNA ...
José M Fernández-Real +9 more
core +1 more source
Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis
Obesity, Volume 33, Issue 3, Page 522-536, March 2025.Abstract Objective Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear.
Manal Al Dow +11 more
wiley +1 more source
Análisis de la expresión de ANGPTL8 en tejido adiposo humano y su posible implicación en obesidad
, 2018 [ES]Introducción: El tejido adiposo está implicado en patologías como obesidad y diabetes. A parte de su papel en el almacenamiento energético, es considerado como un órgano endocrino capaz de sintetizar y liberar adipoquinas.
Catalano-Iniesta, Leonardo
core +1 more source
Journal of Obesity, Volume 2025, Issue 1, 2025.The development of obesity is closely linked to genetic factors. Despite the identification of numerous genes associated with an increased risk of obesity in humans, a comprehensive understanding of their biological roles has not been achieved. In our extensive bioinformatics study, we identified 802 core genes implicated in obesity.
Yuenan Liu +7 more
wiley +1 more source