Results 81 to 90 of about 1,162 (153)

Liver‐specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high‐fat diet‐fed male mice

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
We created a mouse with mature hepatocyte‐specific deletion of DNA methyltransferases. Males, but not females, showed increased adiposity, yet paradoxically, improved glucose tolerance. Comparison of the transcriptome and methylome in adult hepatocytes revealed that widespread loss of methylation in the mutant did not induce loss of homeostatic ...
S. Yao, K. Prates, A. Freydenzon, G. Assante, A. F. McRae, M. J. Morris, N. A. Youngson   +6 more
wiley   +1 more source

Sanghuangporus vaninii extract ameliorates hyperlipidemia in rats by mechanisms identified with transcriptome analysis

Food Science &Nutrition, Volume 12, Issue 5, Page 3360-3376, May 2024.
Extracts of Sanghuangporus vaninii can relieve hyperlipidemia in rats. The results of transcriptomic analysis indicated that S. vaninii extract can activate the AMPK signaling pathway, which subsequently promotes the metabolism of lipids and inhibits the biosynthesis of cholesterol, meanwhile facilitating the excretion of cholesterol, exciting the ...
Ning Gao, Yuanzhen Liu, Guangjie Liu, Bo Liu, Yupeng Cheng   +4 more
wiley   +1 more source

Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension

Lipids in Health and Disease, 2018
Background Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and ANGPTL8, are associated with increased plasma lipid content due to their role in
Mohamed Abu-Farha, Preethi Cherian, Mohamed G. Qaddoumi, Irina AlKhairi, Devarajan Sriraman, Muath Alanbaei, Jehad Abubaker   +6 more
doaj   +1 more source

The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

Journal of Immunology Research, 2020
Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases.
Drahomira Holmannova, Lenka Borska, Ctirad Andrys, Pavel Borsky, Jan Kremlacek, Kvetoslava Hamakova, Vit Rehacek, Andrea Malkova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Zdenek Fiala   +11 more
doaj   +1 more source

CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats

Journal of Lipid Research, 2018
Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived protein that controls plasma triglyceride (TG) levels. Most animal studies have used mouse models.
Ryota Izumi, Toru Kusakabe, Michio Noguchi, Hiroshi Iwakura, Tomohiro Tanaka, Takashi Miyazawa, Daisuke Aotani, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao   +9 more
doaj   +1 more source

Positive correlation of ANGPTL8 expression in human visceral adipose tissue with body mass index

Journal of the Formosan Medical Association
Background: Angiopoietin-like protein 8 (ANGPTL8) is an important regulator of lipid metabolism. We aimed to investigate the difference of ANGPTL8 expression in different depots of adipose tissues between individuals with and without obesity, and its ...
Shiau-Mei Chen, Tse-Ying Huang, Wei-Jei Lee, Lee-Ming Chuang, Tien-Jyun Chang   +4 more
doaj   +1 more source

The correlations between angiopoietin like 8 and cardiometabolic risk factors in Saudi women with type 2 diabetes mellitus: A pilot study

Diabetes & Vascular Disease Research
Purpose This study examines whether Angiopoietin Like 8 (ANGPTL8) is linked to cardiometabolic risk factors (CMRFs) in Saudi women with type 2 diabetes (T2DM).
Walaa Mohammedsaeed, Dalal Binjawhar
doaj   +1 more source

Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8

Gynecological Endocrinology
Background This study aims to explore the value of anti-Müllerian hormone (AMH) in combination with angiopoietin-like protein 8 (ANGPTL8) in evaluating the ovarian function of infertile patients.Methods A total of 213 infertile patients who sought ...
Chongbo Du, Na Wang, Xiaowen Ma, Yanping Feng, Fang Liu, Yandong Deng, Xiaopu Xie, Yuxiao Zhang   +7 more
doaj   +1 more source

ANGPTL8 [PDF]

, 2019
openaire   +1 more source

ANGPTL8 links refeeding to monocyte dynamics and metabolic inflammation via the CCL5-CCR5 axis. [PDF]

JCI Insight
Kan RR, Wang SY, Meng XY, Huang L, Xiang YX, Mao BB, Zou HJ, Guo YM, Pan LM, Luo PQ, Yang Y, Liu ZL, Ma DL, Li WJ, Chen Y, Li DP, Yu XF.   +16 more
europepmc   +1 more source