On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity [PDF]
Journal of Lipid Research, 2019 Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL.
Oleg Kovrov +4 more
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Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study [PDF]
Frontiers in Endocrinology, 2022 ObjectivesThe link between excess adiposity and left ventricular hypertrophy is multifaceted with sparse data among youths. Given that adipokines/hepatokines may influence lipid metabolism in myocardium, we aimed to investigate the relation of the novel ...
Dongmei Wang +12 more
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Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S] [PDF]
Journal of Lipid Research, 2020 Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen +12 more
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Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]
MedicinaBackground and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya +3 more
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Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground ANGPTL8 (angiopoietin‐like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid‐independent mechanisms, remains unclear.
Huimin Ye +6 more
doaj +2 more sources
Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism [PDF]
Lipids in Health and Disease, 2018 Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia.
Mengdie Luo +4 more
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Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy [PDF]
International Journal of Ophthalmology, 2017 AIM: To confirm the role of angiopoietin-like protein 8 (Angptl 8) in proliferative diabetic retinopathy (PDR). METHODS: The sera and aqueous humor of 10 PDR patients and 10 non-diabetic retinopathy (NDR) patients (idiopathic macular hole patients) were
Chang-Xia Dong +6 more
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Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study [PDF]
Cardiovascular Diabetology, 2018 Background Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have remarkably higher levels of ANGPTL8
Xiaolu Jiao +5 more
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Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β ...
Nastaran Monzavi +4 more
doaj +2 more sources
Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study [PDF]
Lipids in Health and Disease, 2018 Background Angiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans.
Song Yang +8 more
doaj +2 more sources