Results 1 to 10 of about 80,391 (145)

Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study [PDF]

Frontiers in Endocrinology, 2022
ObjectivesThe link between excess adiposity and left ventricular hypertrophy is multifaceted with sparse data among youths. Given that adipokines/hepatokines may influence lipid metabolism in myocardium, we aimed to investigate the relation of the novel ...
Dongmei Wang, Dan Feng, Yuhan Wang, Peiyu Dong, Yonghui Wang, Ling Zhong, Bo Li, Junling Fu, Xinhua Xiao, John R. Speakman, John R. Speakman, Ming Li, Shan Gao   +12 more
doaj   +3 more sources

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S] [PDF]

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen, Ajit Regmi, William C. Roell, Haihong Guo, M. Jane Luo, Ruth E. Gimeno, Ferdinand van't Hooft, Robert J. Konrad   +12 more
doaj   +3 more sources

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity [PDF]

Journal of Lipid Research, 2019
Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL.
Oleg Kovrov, Kristian Kølby Kristensen, Erika Larsson, Michael Ploug, Gunilla Olivecrona   +4 more
doaj   +3 more sources

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +3 more sources

Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]

Cell & Bioscience
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen   +7 more
doaj   +3 more sources

Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background ANGPTL8 (angiopoietin‐like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid‐independent mechanisms, remains unclear.
Huimin Ye, Qiang Zhu, Qunchuan Zong, Shanyu Luo, Zonghong Ji, Ruixia Zhang, Huajie Zou   +6 more
doaj   +3 more sources

Circulating angiopoietin-like protein 8 (ANGPTL8) and steatotic liver disease related to metabolic dysfunction: an updated systematic review and meta-analysis [PDF]

Frontiers in Endocrinology
BackgroundSteatotic liver disease related to metabolic dysfunction is the most common cause of chronic liver disease globally. The spectrum of this condition includes steatosis and steatohepatitis and was previously referred to as non-alcoholic fatty ...
Farah Abdelhameed, Farah Abdelhameed, Lukasz Lagojda, Lukasz Lagojda, Chris Kite, Chris Kite, Chris Kite, Alexander Dallaway, Alexander Dallaway, Attia Mustafa, Attia Mustafa, Attia Mustafa, Attia Mustafa, Attia Mustafa, Nwe Ni Than, Eva Kassi, Eva Kassi, Harpal S. Randeva, Harpal S. Randeva, Harpal S. Randeva, Harpal S. Randeva, Ioannis Kyrou, Ioannis Kyrou, Ioannis Kyrou, Ioannis Kyrou, Ioannis Kyrou, Ioannis Kyrou, Ioannis Kyrou   +27 more
doaj   +3 more sources

Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study [PDF]

Cardiovascular Diabetology, 2018
Background Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have remarkably higher levels of ANGPTL8
Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li, Yanwen Qin   +5 more
doaj   +3 more sources

Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China [PDF]

Frontiers in Endocrinology, 2018
Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Liuxue Yang, Jianfei Song, Xiaoxi Zhang, Liuping Xiao, Xueping Hu, Haidong Pan, Linyuan Qin, Hongbo Liu, Bo Ge, Tianpeng Zheng, Tianpeng Zheng   +10 more
doaj   +3 more sources

Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China [PDF]

Cardiovascular Diabetology, 2018
Background Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Tianpeng Zheng, Bo Ge, Hongbo Liu, Bo Chen, Linyuan Qin, Liuping Xiao, Jianfei Song   +6 more
doaj   +3 more sources