Results 11 to 20 of about 96,838 (221)

Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism [PDF]

Lipids in Health and Disease, 2018
Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia.
Mengdie Luo, Xin Su, Yuhong Yi, Yang Yang, Daoquan Peng   +4 more
doaj   +5 more sources

Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy [PDF]

International Journal of Ophthalmology, 2017
AIM: To confirm the role of angiopoietin-like protein 8 (Angptl 8) in proliferative diabetic retinopathy (PDR). METHODS: The sera and aqueous humor of 10 PDR patients and 10 non-diabetic retinopathy (NDR) patients (idiopathic macular hole patients) were
Chang-Xia Dong, Cai-Ping Song, Chun-Ping Zhang, Mei Dong, Xiu-Rong Gong, He-Ying Gao, Hong Wang   +6 more
doaj   +4 more sources

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions. [PDF]

Cardiovasc Drugs Ther, 2020
Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation.
Yang Y, Jiao X, Li L, Hu C, Zhang X, Pan L, Yu H, Li J, Chen D, Du J, Qin Y.   +10 more
europepmc   +5 more sources

Angiopoietin-like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration. [PDF]

J Cell Mol Med, 2019
Intervertebral disc degeneration (IDD) is considered the primary culprit for low back pain. Although the underlying mechanisms remain unknown, hyperactive catabolism of the extracellular matrix (ECM) and inflammation are suggested to play critical roles ...
Liao Z, Wu X, Song Y, Luo R, Yin H, Zhan S, Li S, Wang K, Zhang Y, Yang C.   +9 more
europepmc   +5 more sources

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β ...
Nastaran Monzavi, Seyed Jalal Zargar, Nematollah Gheibi, Mehdi Azad, Babak Rahmani   +4 more
doaj   +4 more sources

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. [PDF]

Diabetologia, 2015
Aims/hypothesisThe identification of novel targets that stimulate endogenous regeneration of beta cells would represent a significant advance in the treatment of patients with diabetes.
Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA.   +5 more
europepmc   +5 more sources

Regulation of angiopoietin-like protein 8 expression under different nutritional and metabolic status.

Endocrine Journal, 2019
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing prevalence worldwide. Angiopoietin-like protein 8 (ANGPTL8), a member of the angiopoietin-like protein family, is involved in glucose metabolism, lipid metabolism, and energy ...
Chang Guo, Zhicong Zhao, Xia Deng, Zian Chen, Z. Tu, Guoyue Yuan   +5 more
semanticscholar   +6 more sources

Angiopoietin-like protein 8 directs DNA damage responses towards apoptosis by stabilizing PARP1-DNA condensates. [PDF]

Cell Death Differ
Upon genotoxic stresses, cells employ various DNA damage responses (DDRs), including DNA damage repair or apoptosis, to safeguard genome integrity. However, the determinants among different DDRs choices are largely unknown. Here, we report angiopoietin-like protein 8 (ANGPTL8), a secreted regulator of lipid metabolism, localizes to the nucleus and acts
Yang J, Wan SY, Song QY, Xie YH, Wan J, Zhou YH, Zhang ZT, Xiao YS, Li X, Chen H, Liu XR, Xu L, You HJ, Hu DS, Petersen RB, Zhang YH, Zheng L, Zhang Y, Huang K.   +18 more
europepmc   +4 more sources

Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression: A case-control study. [PDF]

World J Diabetes
BACKGROUND The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is rapidly increasing, currently affecting approximately 25% of the global population.
Gan LL, Xia C, Zhu X, Gao Y, Wu WC, Li Q, Li L, Dai Z, Yan YM.   +8 more
europepmc   +2 more sources

Angiopoietin-like protein 8 promotes phenotypic transformation of rat aorta vascular smooth muscle cells [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the role and mechanism of angiopoietin-like protein 8 (ANGPTL8) on phenotypic transformation of rat aorta vascular smooth muscle cells (VSMCs).
SUN Qiu-ju, JIAO Xiao-lu, YU Hua-hui, LI Fan, LYU Qian-wen, WANG Yu, QIN Yan-wen
doaj   +2 more sources