Results 21 to 30 of about 26,112 (181)

Relationship Between Angiopoietin-Like Protein 8 and Fasting Serum Triglyceride Level. [PDF]

J Clin Med Res, 2018
The aim of the study was to evaluate the correlation between angiopoietin-like protein 8 (ANGPTL8) and metabolic parameters in non-diabetic healthy humans.We enrolled 30 healthy Japanese adults (25 men and five women). After 9 h of fasting, we collected blood samples and analyzed the ANGPTL8, lipoprotein lipase (LPL), plasma lipid and glucose metabolic
Yamada H, Kusaka I, Saikawa R, Hara K, Kakei M, Ishikawa SE.   +5 more
europepmc   +4 more sources

Molecular mechanism of the effect of angiopoietin-like protein 8 on the proliferation, invasion and migration of placental trophoblasts in preeclampsia. [PDF]

Exp Ther Med, 2020
Preeclampsia (PE) is a pregnancy-specific systemic disorder characterized by various manifestations of organ dysfunction. Inadequate trophoblastic invasion of the uterine wall is involved in the pathogenesis of PE. Angiopoietin-like protein 8 (ANGPTL8) serves an important role in cardiovascular disease development and may have a potential effect on ...
Wang W, Li X, Ji D.
europepmc   +4 more sources

Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome. [PDF]

Cardiovasc Diabetol, 2016
ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3. It has also been suggested to play a role in insulin resistance and beta-cell proliferation. Based on its function, we hypothesized that ANGPTL8 will play a role in Metabolic Syndrome (MetS). To test this hypothesis we designed this study to measure
Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Kavalakatt S, Khadir A, Behbehani K, Alarouj M, Bennakhi A, Elkum N.   +10 more
europepmc   +4 more sources

Histology and molecular biology studies on the expression and localization of angiopoietin-like protein 8 in human tissues. [PDF]

Biomed Rep, 2019
Angiopoietin-like protein (ANGPTL) 8 regulates the partitioning of triglycerides by inhibiting lipoprotein lipase in muscle and adipose tissues. ANGPTL8 is expressed in the liver and adipose tissue and secreted into the blood. However, the precise localization of ANGPTL8-expressing cells in these tissues remains unknown.
Akimoto N, Wada R, Iwakiri K, Naito Z.
europepmc   +4 more sources

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
Circulating ANGPTL8 has recently been used as a marker of insulin action. We studied expression and insulin regulation of ANGPTL8 and ANGPTL3 in vivo and in vitro.Expression of ANGPTL8 and ANGPTL3 was studied in 34 paired samples of human liver and adipose tissue.
Haridas, P. A. Nidhina, Soronen, Jarkko, Sädevirta, Sanja, Mysore, Raghavendra, Quagliarini, Fabiana, Pasternack, Arja, Metso, Jari, Perttila, Julia, Leivonen, Marja, Smas, Cynthia M., Fischer-Posovszky, Pamela, Wabitsch, Martin, Ehnholm, Christian, Ritvos, Olli, Jauhiainen, Matti, Olkkonen, Vesa M., Yki-Jarvinen, Hannele   +16 more
openaire   +3 more sources

A Short Review on ANGPTL-8 as an Important Regulator in Diabetes [PDF]

Avicenna Journal of Medical Biochemistry, 2019
ANGPTL8, a new hormone, is regarded as a novel target for type-2 diabetes and associated metabolic disorder. Nutritional state and hormonal factors are involved in the regulation of ANGPTL-8 expression.
Maryam Esfahani, Mohammad Taghi Goodarzi
doaj   +1 more source

Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice. [PDF]

J Diabetes Mellitus, 2016
Recovery of functional beta cell mass offers a biological cure for type 1 diabetes. However, beta cell mass is difficult to regain once lost since the proliferation rate of beta cells after youth is very low. Angiopoietin like-protein 8 (ANGPTL8), a peptide that has a role in the regulation of lipoprotein lipase activity, was reported to increase beta ...
Liu S, Smith EM, King TH, Glenn L, Trevino M, Park SH, Machida Y, Villaflor C, Grzesik W, Morris MA, Imai Y, Nadler JL.   +11 more
europepmc   +4 more sources

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions. [PDF]

Cardiovasc Drugs Ther, 2020
Abstract Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation. However, the relationship between ANGPTL8 and TAD remains unknown. Methods
Yang Y, Jiao X, Li L, Hu C, Zhang X, Pan L, Yu H, Li J, Chen D, Du J, Qin Y.   +10 more
europepmc   +4 more sources

Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin

Frontiers in Endocrinology, 2023
Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults of Arab ethnicity. However, data on ANGPTL8 levels in adolescent obesity is lacking.
Maha M. Hammad, Arshad M. Channanath, Mohamed Abu-Farha, Abdur Rahman, Irina Al Khairi, Preethi Cherian, Tahani Alramah, Nada Alam-Eldin, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker   +10 more
doaj   +1 more source

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea [PDF]

Frontiers in Endocrinology, 2018
Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (
Abdulmohsen Al-Terki, Mohamed Abu-Farha, Irina AlKhairi, Preethi T. Cherian, Devarajan Sriraman, Ambika Shyamsundar, Shamsha Ali, Fahd Almulla, Jaakko Tuomilehto, Jehad A. Abubaker   +9 more
openaire   +3 more sources