Results 41 to 50 of about 14,305,425 (198)

Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]

Jichu yixue yu linchuang
Objective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
doaj   +1 more source

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Journal of Lipid Research, 2022
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting ...
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad   +16 more
doaj   +1 more source

Calcium binding activity of the epidermal growth factor-like domains of the apicomplexan microneme protein EtMIC4 [PDF]

, 2005
Microneme proteins are secreted from apicomplexan parasites during invasion of host cells and they play crucial roles in parasite-host cell adhesion.
Gill, A C, Knott, V, Tomley, F M, Periz, J, Tomley, FM, Handford, P A, Gill, AC, Handford, Penelope, Handford, PA   +8 more
core   +1 more source

Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways [PDF]

, 2017
ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature.
Chris T. Evelo, Eijssen, Lars, Coort, Susan L; id_orcid, Elisa Cirillo, Tareen, Samar H K, Ahmad, Jamil, Martina Kutmon, Siddiqa, Amnah, Coort, Susan L, Evelo, Chris T; id_orcid, Kutmon, Martina; id_orcid, Eijssen, Lars; id_orcid, Jamil Ahmad, Evelo, Chris T, Cirillo, Elisa, Amjad Ali, Lars M.T. Eijssen, Amnah Siddiqa, Susan L. Coort, Ali, Amjad, Kutmon, Martina, Samar H.K. Tareen   +21 more
core   +2 more sources

Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus. [PDF]

, 2021
Background: The degree of systemic inflammation, reperfusion injury and endothelial activation are potentially important determinants of clinical outcomes in dogs with gastric dilatation volvulus (GDV).
Schuller, Simone, Brunner, Anna, Marti, Eliane, Lehmann, Anna, Peters, Laureen M, Hettlich, Bianca, Adamik, Katja-Nicole   +6 more
core   +2 more sources

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Role of Angiopoietin like protein-8 as a predictive marker of diabetic nephropathy in type 2 diabetes mellitus [PDF]

Minia Journal of Medical Research
Background: Diabetic nephropathy is a critical complication of T2DM. Its prevalence is 30-40% of individuals with long-standing T2DM. DN can cause damage to the small blood vessels of the kidneys impairing their functions in filtering waste and excess ...
Emad Abdelnaem, Naglaa Farag, Reham Ashour, Aya Najib, Dalia Meshref   +4 more
doaj   +1 more source

Association of Angiopoietin-Like Protein-8 Gene Variant (Rs2278426 (C/T)) in a Cohort of Egyptian Patients with Metabolic Syndrome: A Case-Control Study

Clinical Diabetology, 2023
OBJECTIVE: This study was conducted to reveal the association of ANGPTL8 gene variant (Rs2278426 (C/T)) with metabolic syndrome in a cohort of Egyptian patients.
Talaat Abdel-Fattah Abdel-Aty, Eman Yousef Moursi, Eman Tayae Elsayed, Marwa Ahmed Salah, Sary Ibrahim Abdelsalam   +4 more
doaj   +1 more source

Functional characterization of Angptl4 protein [PDF]

, 2009
Background: Elevated plasma triglycerides (TG) are increasingly recognized as a risk factor for atherosclerosis. A new adipocytokine was discovered by several groups which is referred to as Angptl4 (Angiopoietin-like protein 4).
Lichtenstein, L.L.
core  

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Koblizek, T., Marme, D., Augustin, HG, Augustin, H. G., Fiedler, U, Krissl, T., Martiny-Baron, G., Krissl, T, Koidl, S., Martiny-Baron, G, Deutsch, U, Fiedler, U., Weiss, C., Deutsch, U., Koidl, S, Koblizek, T, Marmé, D   +17 more
core   +1 more source